GLIOBLASTOMA

This early-stage trial tested an mRNA vaccine (CVGBM) in 37 people with a fast-growing brain cancer called glioblastoma. Participants received the vaccine after surgery and radiation. The main goal was to check safety and find the right dose. This is a first step to see if the va…

This study tested a technique where patients drink a special liquid (5-ALA) before brain surgery for glioblastoma, a fast-growing brain tumor. The liquid makes tumor cells glow under a special light, helping surgeons see and remove more of the cancer compared to using standard co…

This early-phase study tested whether adding a 4-month ketogenic diet to standard radiation and chemotherapy is safe and doable for people with newly diagnosed glioblastoma, a serious brain cancer. Twenty-one adults followed personalized meal plans designed to keep their bodies i…

This study tested whether adding two immune-boosting drugs (retifanlimab and epacadostat) to standard radiation and bevacizumab could help people with recurrent glioblastoma, a fast-growing brain tumor. The trial enrolled 51 adults whose cancer had returned. The goal was to see i…

This small pilot study tested whether adding a focused ultrasound device (NaviFUS) to standard chemotherapy (bevacizumab) could help control recurrent glioblastoma, an aggressive brain cancer. Six adults whose cancer returned after prior treatment took part. The main goals were t…

This early-phase study tested the safety of combining two drugs (pembrolizumab and vorinostat) with standard chemotherapy and radiation in 21 people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal was to find the highest safe dose of vorinostat in this com…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced solid tumors including breast, ovarian, stomach, colorectal, brain, bile duct, and pancreatic cancers that had stopped responding to standard treatments. The goal was to see if…

This study tested whether adding a metabolic therapy program—which includes fasting and a ketogenic diet—to standard treatment (chemotherapy and radiation) is safe and doable for people with glioblastoma, a very aggressive brain cancer. The idea is that this diet may starve cance…

This early-phase study tested a combination of two drugs (low dose capecitabine and bevacizumab) in 12 people whose glioblastoma brain tumor had come back. The goal was to see if the treatment could reduce certain immune cells that help the tumor hide from the body's defenses. Th…

This early-phase study tested two drugs, ASP8374 and cemiplimab, in 14 people with a returning type of brain cancer called glioblastoma. The main goals were to find a safe dose and see if giving the drugs before surgery could boost the immune response against the tumor. The study…

This study tested a new drug (LY2157299) alone or with standard chemotherapy (lomustine) in 158 adults whose glioblastoma brain cancer had returned after initial treatment. The goal was to see if the new drug could help people live longer or slow tumor growth. Results are not yet…

This study tested whether adding a combination of THC and CBD (cannabinoids from cannabis) to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. About 30 adults aged 18 to 70 took part. The goal was to find the hi…

This study tested a stronger light dose during surgery for glioblastoma, a serious brain cancer. 14 patients received the light therapy along with standard treatment (surgery, chemo, and radiation). The goal was to find the highest safe light dose and see if it helps control the …

This study tested a new way to remove glioblastoma brain tumors. Doctors used an AI model to predict where the tumor is likely to come back, then removed extra tissue in those areas during surgery. The goal was to see if this approach is safe and could help patients live longer. …

This small pilot study tested whether adding a light-activated drug treatment during surgery is safe and feasible for people with glioblastoma, an aggressive brain cancer. Ten patients received the therapy alongside standard surgery and chemoradiation. The main goal was to see if…

This study tested whether a focused ultrasound device (ExAblate) can safely and repeatedly open the blood-brain barrier in 20 adults with high-grade glioma (a type of brain cancer). The goal was to help standard chemotherapy reach the tumor more effectively. Researchers measured …

This study tested whether adding an immune cell treatment called Immuncell-LC to standard chemotherapy (temozolomide) helps people with newly diagnosed glioblastoma, an aggressive brain cancer. 180 adults in Korea took part. The main goal was to see if the combination slowed canc…

This study tested whether adding an immunotherapy drug (durvalumab) to focused radiation therapy can help people with recurrent glioblastoma, an aggressive brain cancer that has come back after initial treatment. The trial involved 108 adults and first checked safety, then random…

This early-phase study tested a combination of three treatments for people newly diagnosed with glioblastoma, an aggressive brain cancer. The approach adds tumor treating fields (electric fields that disrupt cancer cell division) and focused radiation to standard chemotherapy. Th…

This study tested a personalized vaccine made from a patient's own tumor cells and immune cells (dendritic cells) for people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal was to see if the treatment is safe and can help delay tumor growth. 76 participant…

This early study tested if a focused ultrasound device can safely open the blood-brain barrier in 3 adults with aggressive brain tumors (glioblastoma) during standard chemotherapy. The goal was to see if the procedure is safe and can be repeated, potentially allowing more chemo t…

This study tested a drug called VAL-083 combined with standard radiation for people newly diagnosed with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to find a safe dose and see if the combination helps control th…

This early-phase study tested the drug TG02 in 71 patients with aggressive brain tumors (anaplastic astrocytoma or glioblastoma). The goal was to find the safest dose when combined with either radiation or chemotherapy. The study focused on newly diagnosed elderly patients and th…

This study tested whether adding whole brain radiation and a drug called plerixafor to standard chemotherapy can help people with a fast-growing brain tumor called glioblastoma. The trial included 21 newly diagnosed patients. The goal was to see if this combination could slow tum…

This study tested adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation for people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal was to see if the combination is safe and helps patients live longer. The trial enrolled 60 parti…

This study tested whether ramipril, a common blood pressure medicine, could help prevent memory loss in 75 people with glioblastoma who were receiving brain radiation and chemotherapy. Participants took ramipril during treatment and for four months after. Researchers measured mem…

This study looked at whether a type of talk therapy called cognitive behavioral therapy for insomnia (CBT-I) can help people with brain tumors who have trouble sleeping. The study included 70 adults with various brain tumors who also had insomnia. The goal was to see if the thera…

This study tested whether an expensive PET scan called 18F-FDOPA helps doctors choose better treatments for people with high-grade gliomas, a type of aggressive brain tumor. About 110 patients whose cases were discussed by a team of experts were included. The main goal was to see…

This study looked at whether a combination of two drugs, LY3214996 and abemaciclib, can reach brain tumors in people with recurrent glioblastoma. About 42 participants took the drugs before surgery to remove their tumor. Researchers measured drug levels in the tumor tissue and sp…

This study looked at whether video visits (telehealth) are as satisfying as in-person clinic visits for people with brain tumors (gliomas) who are taking oral chemotherapy. Thirty patients alternated between telehealth and in-person checkups, and researchers measured their satisf…

This study looked at memory complaints in 426 people, including those with brain tumors, breast cancer, and healthy volunteers. Researchers focused on 'prospective memory'—remembering to do things in the future, like taking medication. They found that cancer patients reported mor…

This study looked at 244 people with glioblastoma, a serious brain cancer, to see if changes in platelet counts during early treatment could predict later blood problems. The goal was to create a monitoring plan to catch low platelet levels early. The study did not test a new tre…

This study looked at brain tissue from 20 glioblastoma patients after they passed away. The goal was to understand how a treatment called tumor treatment fields (TTFields) affects cancer cells at a microscopic level. Researchers counted active and inactive cells to see how the tr…

This study looked at whether a special MRI technique can identify the most aggressive parts of a glioblastoma brain tumor. Researchers took tissue samples from different areas of the tumor during surgery and tested them for cancer stem cells. The goal was to see if MRI markers ma…

This study looked at how much of the numbing drug lidocaine gets into brain tumors during surgery for glioblastoma, an aggressive brain cancer. Researchers measured lidocaine levels in the blood and tumor tissue of 12 patients. The goal was to gather information that could help d…

This study looked at whether special brain scans (PET and CT perfusion) can predict how well the drug bevacizumab works in people with a returning brain tumor called glioblastoma. Fourteen patients were enrolled. The goal was to see if these scans could tell doctors early on who …

This small pilot study tested whether a special type of PET/CT scan (FDG PET/CT) can detect very early changes in brain tumors (glioblastoma) after starting chemotherapy. The idea is that tumors use sugar differently when they respond to treatment, and this scan measures sugar up…

This study examined 47 adults with newly diagnosed glioblastoma or gliosarcoma to see if changes in immune cells in the blood could predict how well they respond to a combination of immunotherapy drugs (ipilimumab and nivolumab) plus standard chemotherapy. Participants had alread…

This study looked at whether using fluorescent dyes during brain tumor surgery helps surgeons remove more of the tumor. Researchers reviewed records of 41 patients with aggressive brain tumors treated at one hospital. They compared surgeries done with and without the dye to see i…

This study looked at tumor tissue and blood samples from 141 adults with glioblastoma or other solid tumors. The goal was to measure cell counts and viability to help scientists develop better treatments in the future. Participants were already scheduled for surgery, and the stud…