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Glow-in-the-Dark dyes may help surgeons remove more brain tumor

NCT ID NCT07499141

Knowledge-focused Sponsor: Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked back at medical records of 41 patients who had surgery for aggressive brain tumors (high-grade gliomas). Some surgeries used fluorescent dyes that make tumor tissue glow, helping surgeons tell it apart from healthy brain. The goal was to see if using these dyes leads to more complete tumor removal, as confirmed by MRI scans. The study did not test a new treatment, but rather reviewed past cases to learn how well these dyes work.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

41 people

The number who actually took part.

Started

Sep 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

A total of 45 patients undergoing surgery for high-grade brain glioma will be enrolled at the Azienda Ospedaliero-Universitaria "SS Antonio e Biagio e Cesare Arrigo" in Alessandria, during the period from June 2023 to March 2024.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients hospitalized at the AOU AL (Neurosurgery Department) and undergoing surgical removal of a brain lesion compatible with ICD-9 diagnosis: * 191 MALIGNANT TUMORS OF THE BRAIN * 191.1 MALIGNANT TUMORS OF THE FRONTAL LOBE * 191.2 MALIGNANT TUMORS OF THE TEMPORAL LOBE * 191.3 MALIGNANT TUMORS OF THE PARIETAL LOBE * 191.4 MALIGNANT TUMORS OF THE OCCIPITAL LOBE * 191.9 MALIGNANT TUMORS OF THE BRAIN, UNSPECIFIED * Signing of informed consent Exclusion Criteria: * Incomplete electronic records or missing clinical data useful for this study. * Patients not eligible for surgical intervention * Patients affected by a neoplasm not compatible with a histological diagnosis of high-grade glioma

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm glioblastoma glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain neoplasms Glioblastoma High grade glioma

Contacts and locations

Locations

  • Clinical Trial Center, Alessandria, Piedmont 151121

    Alessandria, Italy, 15121, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.