HIGH GRADE GLIOMA

This study tests a vaccine called PEP-CMV in 120 children and young adults with aggressive brain tumors (high-grade glioma, DIPG, or recurrent medulloblastoma). The vaccine targets a protein from a common virus (CMV) that often hides in these tumors, aiming to train the immune sy…

This study tests a new treatment for people with brain tumors that have a protein called GD2. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack the tumor. A special gene is added to help these cells survive longer in th…

This study tests whether adding two experimental drugs, DB107-RRV and DB107-FC, to standard treatment (radiation and chemotherapy) helps people with newly diagnosed high grade glioma, a fast-growing brain tumor. About 70 adults aged 18-75 will receive the drugs during surgery and…

This study tests a new drug called LMP744 in 40 adults whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or slow their growth.

This study is testing an experimental drug called LAM561 in children under 18 with advanced brain tumors (like high-grade glioma) or other solid cancers that have stopped responding to standard treatments. The goal is to find a safe dose and see how well the drug is tolerated. Up…

This early-stage study tests a new treatment for children and young adults (up to age 21) with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified to target a protein called B7-H3 on tumor cell…

This study tests whether adding two different drug combinations after radiation can help children and young adults with high-grade gliomas (including DIPG) live longer. One group receives ribociclib plus everolimus, and another receives ribociclib plus temozolomide, based on the …

This study follows up to 100 people with cancers like melanoma, lung cancer, or rare tumors who are already benefiting from treatment with dabrafenib and/or trametinib. The goal is to monitor long-term safety and side effects while patients continue their medication. Participants…

This early-phase study tests a new drug called XRD-0394 combined with radiation therapy for people with high-grade gliomas, a fast-growing brain cancer. The main goal is to find a safe dose and check for side effects. About 39 adults with newly diagnosed or returning tumors will …

This study tests a drug called Lutathera in children and young adults (ages 4 to 39) whose brain tumors have come back or are growing despite treatment. The drug delivers radiation directly to tumor cells that show up on a special PET scan. The goal is to find the safest dose and…

This study tests a drug called entrectinib for children under 3 with specific types of brain tumors (NTRK or ROS1-fused). The drug targets the genetic changes driving the tumor, aiming to shrink it and delay growth. About 52 children will receive the drug alone, avoiding traditio…

This study tests a drug called larotrectinib in children (up to age 21) with a newly diagnosed, aggressive brain tumor (high-grade glioma) that has a specific genetic change (NTRK fusion). The goal is to see if the drug can shrink or control the tumor after two cycles, and to che…

This early-phase trial tests a personalized RNA vaccine made from each patient's own tumor. It aims to train the immune system to fight aggressive brain cancers like glioblastoma and high-grade glioma. The study enrolls up to 28 adults and children to check safety, manufacturing …

This study tests a drug called lorlatinib in children (ages 1-21) with a newly diagnosed, aggressive brain tumor that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given alone or wit…

This study tests an experimental drug, BDTX-1535, in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have certain changes in the EGFR gene. The drug aims to block a growth signal that these tumors rely on. The study will check how much drug reaches th…

This early-phase study tests a new treatment for adults with glioblastoma or high-grade glioma that has come back after standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to target two different markers on tumor cells at once, which may h…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This early-phase trial tests a new treatment called TX103 CAR-T for people with a severe and fast-growing brain cancer (grade 4 glioma) that has come back or gotten worse. The therapy uses the patient's own immune cells, modified to better attack the cancer. The main goals are to…

This study is testing whether a special PET-MRI scan using 18F-fluciclovine can help doctors tell the difference between actual tumor growth and harmless changes that happen after treatment in children with high-grade glioma. About 30 children aged 1 to 21 with this type of brain…

This study looks at whether PET scans and blood tests can predict how radiation treatment for high-grade glioma affects memory and thinking. About 16 adults with this type of brain tumor will have scans and cognitive tests before and after treatment. The goal is to find ways to i…

This study tests if recording electrical activity in and around high-grade glioma tumors during surgery is safe and feasible. Researchers will take small biopsies at recording sites and follow patients with MRI scans to see if brain activity patterns can predict where the tumor w…

This study collects tumor tissue from 50 adults with low- or high-grade glioma to create living organoids in the lab. Researchers will study these organoids to learn why gliomas are so hard to treat. The goal is to find new ways to predict and improve treatment outcomes. No direc…

This study aims to analyze the genetic makeup of brain tumors in children, teens, and young adults (ages 1 to 39) newly diagnosed with high-grade glioma, including a type called DIPG. By identifying specific genetic changes in each tumor, researchers hope to match patients with m…

This study tests a special version of the cancer drug nivolumab that has a fluorescent dye attached, called nivo800. The dye makes the drug glow under a special camera, allowing surgeons to see where the drug goes in the brain during tumor removal. The goal is to learn how well t…

This study is developing a special biopsy needle that uses light and sound to help doctors see tumor tissue and blood vessels in real time. The goal is to make brain tumor biopsies safer and more accurate. The study will test the needle on tumor tissue removed during surgery from…

This study tests a new type of PET/MRI scan to see if it can find active high-grade glioma (a serious brain cancer) in children and adults after they finish standard radiation therapy. About 20 participants will get the special scan, and doctors will follow them for up to 2 years…