HIGH GRADE GLIOMA

This study tests a drug called tovorafenib in children and young adults (ages 1 to 39) newly diagnosed with aggressive brain tumors (high-grade glioma or DIPG) that have specific genetic changes. The goal is to see if the drug can help patients live longer by targeting those gene…

This early-phase study tests whether a new radiation technique, guided by real-time MRI and tumor biology, can safely deliver higher doses to aggressive brain tumors (grade 3 or 4 gliomas). About 20 adults with newly diagnosed tumors will receive targeted radiation using an MR-Li…

This early-phase study tests a new treatment for children and young adults with aggressive brain tumors called high-grade glioma and DIPG. The therapy uses the patient's own immune cells, modified to better find and attack the tumor. The main goals are to see if the treatment is …

This early-stage study tests a new treatment for people with recurrent high-grade glioma, an aggressive brain cancer. The therapy combines a specially designed virus that targets cancer cells with an immunotherapy drug that helps the immune system attack the tumor. The main goal …

This study tests whether adding an experimental drug (ADI-PEG 20) to standard radiation and chemotherapy can help children, teens, and young adults with newly diagnosed high-grade glioma. About 97 participants will receive the drug combination to see if it is safe and delays tumo…

This early-phase study tests a nasal spray called NEO100 in 12 children with specific, hard-to-treat brain tumors. The main goals are to check safety, find the best dose, and see if the drug reaches the tumor. It is a first step to see if this approach is safe enough for larger s…

This study tests whether special MRI scans can spot areas of brain tumor that standard scans miss. About 20 adults with suspected high-grade glioma will get extra scans before surgery. The goal is to better understand how far the tumor has spread, which could help doctors plan mo…