New MRI technique could reveal invisible brain tumor edges

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult patients (both male and female, \>= 18 years old) 2. Previously acquired MRI suggestive for the presence of high-grade glioma 3. Treatment-naïve status, defined as no prior surgical, radiotherapeutic, or systemic oncological treatment for the index brain lesion. 4. Indication for biopsy or tumor resection 5. Willingness to participate to the study and ability to sign informed consent Exclusion Criteria: 1. Pregnancy (to be excluded through a human chorionic gonadotropin pregnancy test performed on urine or serum when childbearing potential) and / or lactation. 2. Contraindications to MRI because of: I. Claustrophobia II. Presence of metallic objects or implanted medical devices in body (i.e., cardiac pacemaker, aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants) III. Sickle cell disease IV. Renal failure or reduced renal function, as determined by Glomerular Filtration Rate (GFR) \< 30 mL/min/1.73 m\^2 based on a serum creatinine level obtained within 40 days prior to registration 3. Presence of any other co-existing condition (such as serious systemic illness, including uncontrolled intercurrent infection, uncontrolled malignancy, significant renal or hepatic disease, or psychiatric/social situations) which might, in the judgment of the investigator, increase the risks to the subject or limit compliance with study requirements 4. Inability to undergo surgical procedures 5. Severe hepatic impairment, defined as the presence of two or more of the following parameters (assessed within 40 days): bilirubin ≥3 mg/dL, albumin \<2.8 g/dL, International normalized ratio \>2.3 with no history of anticoagulant therapy, platelet count \< 100 109/L, AST ≥ 400 U/L, ALT ≥400 U/L, presence of ascites.