HIGH GRADE GLIOMA

This early-phase study tested whether a custom-made vaccine and special immune cells (T-cells) could be given safely to children with newly diagnosed high-grade gliomas, a very aggressive brain cancer. The treatment used the patient's own tumor to create a vaccine that would trai…

This study tested giving chemotherapy and radiation before surgery for people with a newly diagnosed, removable glioblastoma (a fast-growing brain cancer). The goal was to see if this approach could improve tumor control and survival. Only 2 people enrolled before the trial was s…

This early-phase study tested a new approach called sonodynamic therapy for people with recurrent high-grade glioma, a fast-growing brain tumor. Participants received a drug called ALA followed by focused ultrasound to activate it. The goal was to check safety and see if the trea…

This early-stage trial enrolled 5 people with recurrent high-grade glioma (a type of aggressive brain tumor). Participants received a single dose of the drug temsirolimus, given directly into the brain's blood vessels or through a vein, on the same day as planned tumor removal su…