HIGH GRADE GLIOMA

This early-stage trial tests the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose brain tumors (low- or high-grade gliomas) have returned after prior treatment. The drugs work by blocking different growth signals in t…

This study aimed to test an experimental virus therapy, G207, given directly into the brain tumor along with a single dose of radiation for children whose high-grade glioma had come back after standard treatment. The goal was to see if this combination could help children live lo…

This study tests a single injection of a virus (DNX-2401) directly into brain tumors in children and young adults whose cancer has come back or not responded to treatment. The goal is to see if the virus can shrink tumors and help patients live longer. 39 participants will receiv…

This study tests whether the immunotherapy drug nivolumab can help control brain tumors called gliomas that have specific genetic changes (IDH mutations). About 62 adults with these tumors will receive nivolumab through an IV every few weeks. The main goal is to see if the drug c…

This study is testing a new drug called PTC596 (Unesbulin) given alongside radiation therapy for children and teens (ages 1-21) newly diagnosed with aggressive brain tumors like DIPG or high-grade glioma. The main goal is to find a safe dose and check for side effects. Participan…

This early-phase study tests a new drug called DSP-0390 in 39 adults whose high-grade glioma (a fast-growing brain tumor) has come back after prior treatment. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants must be …

This study is testing a new drug called CLR 131, a targeted radiotherapy, in children, teens, and young adults (ages 10 to 25) with a type of brain cancer called high-grade glioma that has come back or not responded to treatment. The main goals are to find the best dose and check…

This early-phase study tests whether a special PET scan (68Ga-PSMA-11) can spot active tumor tissue in people with high-grade glioma or brain metastases. Eleven adults whose tumors are at least 1 cm and who are already scheduled for a biopsy or surgery will receive the scan befor…

This early-phase study tests the safety of adding the drug azeliragon to radiation therapy for adults whose cancer has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). About 21 participants with solid tumors or high-grade gliomas will receive the com…

This study aims to develop a simple blood test (liquid biopsy) to monitor high-grade gliomas, an aggressive type of brain tumor. Researchers will collect blood samples from 70 adult patients before and after treatment to see if they can detect tumor DNA and track changes over tim…

This study looks at people with a type of brain cancer called glioma that has a specific gene change (IDH mutation). Researchers use special MRI scans to measure a substance called 2-HG in the brain over time, which may show when the tumor becomes more aggressive. The goal is to …