HIGH GRADE GLIOMA

This early-stage study is testing a new targeted radiation drug called CLR 131 in children and young adults (ages 10-25) with aggressive brain tumors that have returned or not responded to other treatments and cannot be removed by surgery. The main goals are to find a safe and ef…

This early-stage study is testing whether a modified version of a patient's own immune cells can be safely used to treat aggressive brain tumors in children and adults. Researchers will collect immune cells from patients, modify them to better target tumor cells, and then return …

This early-stage study is testing the safety and finding the right dose of an experimental oral drug called DSP-0390 for adults whose aggressive brain tumors (high-grade gliomas) have returned. The main goals are to see what side effects occur and to measure how the drug behaves …

This study aimed to test a new treatment for children whose aggressive brain tumors had returned. The treatment involved injecting a specially engineered virus directly into the tumor, followed by a single low dose of radiation. The goal was to see if this combination could help …

This early-stage study is testing a new, personalized vaccine made from a patient's own tumor RNA. It aims to see if this vaccine is safe and to find the best dose for adults with a type of brain cancer called glioblastoma and for children with high-grade brain tumors. The vaccin…

This study is testing the safety of a new oral drug called PTC596 (Unesbulin) when given alongside standard radiation therapy to children and young adults newly diagnosed with aggressive brain tumors, including a very hard-to-treat type called DIPG. The main goals are to find the…

This study is testing whether the immunotherapy drug nivolumab can help control the growth of certain brain tumors (gliomas) that have specific genetic changes. It is enrolling 62 adults whose tumors have either a very high number of mutations or a normal number. The main goal is…

This study is testing a new type of PET scan to see if it can effectively show activity in aggressive brain tumors. It involves adults with high-grade gliomas or brain metastases who are already scheduled for a biopsy or surgery. The goal is to see if this scan can provide cleare…

This study aims to develop a better blood test to monitor high-grade brain tumors without surgery. Researchers will collect up to 10 blood samples from 70 patients to see if they can detect and track tumor DNA in the blood over time, especially before and after radiation treatmen…

This study aims to understand how a specific type of brain tumor (glioma) changes and becomes more aggressive over time. Researchers will use special brain scans to track chemical levels in the tumors of about 42 adults who have this condition. The goal is to learn if these chemi…