Could a Virus-Fighting vaccine shrink deadly childhood brain tumors?
NCT ID NCT05096481
First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 26 times
Summary
This study tests a vaccine called PEP-CMV in 120 children and young adults with aggressive brain tumors (high-grade glioma, DIPG, or recurrent medulloblastoma). The vaccine targets a protein from a common virus (CMV) that often hides in these tumors, aiming to train the immune system to attack the cancer. Participants receive the vaccine after standard treatments like radiation. The goal is to see if this approach can slow tumor growth or improve survival.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
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C.S. Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Dana-Farber Cancer Institute
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
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Duke Cancer Center
RECRUITINGDurham, North Carolina, 27710, United States
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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Nicklaus Children's Hospital
RECRUITINGMiami, Florida, 33155, United States
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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St. Louis Children's Hospital
RECRUITINGSt Louis, Missouri, 63110, United States
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
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Conditions
Explore the condition pages connected to this study.