BRAIN NEOPLASMS

This trial is testing if a drug called entrectinib, already approved for some lung cancers, can help control other rare cancers that share the same genetic change (called ROS1-positive). It aims to enroll about 30 adults and children with these rare cancers to see if the drug shr…

This study is testing whether two drugs, elacestrant and abemaciclib, work together to control breast cancer that has spread to the brain. It will involve about 73 adults whose cancer is fueled by estrogen and has spread to the brain. The first part finds the safest dose, and the…

This early-stage study is testing the safety and initial effects of a new oral medicine, PF-07799544, when taken with another drug, PF-07799933. It is for adults with advanced solid tumors, like melanoma or lung cancer, that have a specific genetic change called a BRAF V600 mutat…

This study is testing a new type of MRI scan to see if it can find brain tumors better than the standard MRI method. Adults who are already scheduled for a brain MRI and have known or suspected brain tumors will get both the standard scan and the new scan during the same appointm…

This study is testing a new device called HIVEN® that aims to help surgeons remove more brain tumor tissue during surgery. The device analyzes the fluid and tissue that is suctioned away during the operation, checking it for a fluorescent dye that highlights cancer cells, and giv…

This study is testing whether a 6-week group program led by occupational therapists can help adults with primary brain tumors feel better and manage daily life while they are receiving cancer treatment. About 96 participants will be randomly assigned to either join the weekly gro…

This study is testing a home-based program called HOBSCOTCH-CA, designed to help brain cancer survivors manage memory and thinking problems that often follow their illness. Participants will work one-on-one with a coach over video calls to learn problem-solving and relaxation tec…

This study is testing whether a brief, 5-minute guided meditation played during radiation therapy sessions can help reduce anxiety for people with brain tumors. Researchers will compare the meditation group to patients receiving standard care (no meditation) to see if it makes a …

This study aims to understand if platelets, tiny blood cells, are present inside brain tumors and if their presence is linked to how long patients live. Researchers will collect and analyze tumor tissue and blood samples from 50 adults undergoing surgery for brain or spinal cord …

This study is testing whether a small device called an Ommaya reservoir can be safely placed during a brain tumor biopsy. The device allows doctors to collect fluid samples from around the brain over time without repeated spinal taps. Researchers hope these samples will help them…