BRAIN NEOPLASMS

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. About 73 adults are being…

This study tests a drug called entrectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change (ROS1 fusion). About 30 adults and children with these rare tumors will receive the drug. Researchers will measure if tumors shrink …

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study tests a new type of MRI scan that may help doctors see brain metastases more clearly. About 100 adults with known or suspected brain tumors will get both a standard MRI and the new scan. The goal is to see if the new method finds more or smaller tumors without extra co…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants will take part in virtual coaching sessions over 6 months, learning problem-solving and relaxation techniques. The …

This study tests a 6-week occupational therapy group program for adults with primary brain tumors who are on active treatment. The program covers fatigue management, thinking strategies, relaxation, and peer support. Researchers want to see if it improves quality of life and dail…

This study tests whether a 5-minute guided meditation played during each radiation session can lower anxiety in people with brain tumors. About 30 adults will either listen to the meditation or receive standard care. Researchers will measure anxiety levels before and after each t…

This study looks at whether placing a small device called an Ommaya reservoir under the scalp during a brain tumor biopsy can help doctors safely collect fluid samples over time. About 20 people with suspected or known brain tumors will take part. The goal is to see if this appro…

This study looks at platelets (small blood cells) in brain and spinal cord tumors to see if they affect tumor growth and patient survival. Researchers will examine tumor samples from 50 adults undergoing surgery. No new treatment is given; the goal is to learn how platelets inter…

This study tests a new method to detect leftover brain tumor cells during surgery by analyzing waste from the suction device. It includes 8 adults with suspected high-grade gliomas or other brain tumors. The goal is to see if this approach can find tumor cells that are missed by …