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Brain surgery gets a GPS: new trial aims to save speech and movement

NCT ID NCT07657403

Disease control Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using advanced brain network mapping (connectome-guided navigation) during surgery can better preserve functions like speech and movement in people with brain tumors in critical areas. Two hundred participants will be randomly assigned to either this new technique or standard surgery. The main goal is to see if more patients keep their neurological abilities six months after the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Connectome-guided navigation-assisted microsurgical resection (a surgical procedure using brain network mapping to guide tumor removal)
What this could lead to
If successful, this could become a new standard for brain tumor surgery that better protects language, movement, and other critical functions.
What could go wrong
This is a single-center trial with 200 participants, so results may not apply to all patients. The technique is complex and may not always improve outcomes over standard methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients clinically diagnosed with brain tumors involving language areas, motor areas, or major functional brain networks, including the default mode network, central executive network, dorsal attention network, or ventral attention network. 2. Karnofsky Performance Status (KPS) score of 70 or higher. 3. Preoperative MRI demonstrating a spatial relationship between the tumor and major white matter tracts, such as the corticospinal tract or arcuate fasciculus. 4. No other neurological disease or underlying condition that may cause neurological dysfunction. 5. No prior treatment for a brain tumor in the same region, such as radiotherapy. 6. Tumor not extensively adherent to multiple critical network nodes. 7. Planned craniotomy for tumor resection and provision of written informed consent by the patient or legally authorized representative. Exclusion Criteria: 1. Pathologically or clinically suspected non-neoplastic brain lesion. 2. Multifocal tumors. 3. Incomplete evaluation data. 4. Withdrawal from the study by the patient or legally authorized representative for any reason. 5. Pregnancy, lactation, possibility of pregnancy, or planned pregnancy.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain neoplasms Eloquent area brain tumors

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

    RECRUITING

    Beijing, 100021, China

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