GLIOBLASTOMA

This phase III trial is testing whether delivering the drug bevacizumab (Avastin) directly to the brain through a catheter, along with standard chemo and radiation, can help people with newly diagnosed glioblastoma live longer. The study will enroll 432 adults with this aggressiv…

This early-stage trial tests whether combining a laser heat treatment (LITT) with the chemotherapy drug lomustine is safe and feasible for adults with recurrent glioblastoma, an aggressive brain cancer. About 20 participants will receive the laser procedure followed by lomustine …

This early-stage trial tests a new approach for people with recurrent glioblastoma, a fast-growing brain tumor. Doctors take immune cells called NK cells, engineer them to recognize and attack tumor cells, and deliver them directly into the brain. The study will check safety and …

This early-phase study tests the drug lorlatinib in children and young adults (ages 1 to 21) with newly diagnosed high-grade glioma, a fast-growing brain tumor, that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor…

This study tests a gene therapy (HSV-tk) plus valacyclovir alongside radiation and chemotherapy for people newly diagnosed with glioblastoma or anaplastic astrocytoma. The goal is to see if this combination improves survival. About 62 participants will receive the gene therapy in…

This early-stage trial tests an oral drug called GLIX1 in 30 adults with recurrent or progressive high-grade glioma, a fast-growing brain cancer. The study aims to find the safest dose and check for any signs of tumor control. Participants take the drug daily until their disease …

This early-phase trial is testing a radioactive drug called 131I-TLX101, given alongside standard care, for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study involves 12 participants and aims to find the safest dose and check for side effects. It is …

This Phase 3 trial tests whether adding a special radiation tile (GammaTile) during brain surgery improves survival for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 766 participants will be randomly assigned to standard treatment (surgery, radiatio…

This large international trial is testing several drugs and radiation in people with newly diagnosed or recurrent glioblastoma, an aggressive brain cancer. The study uses an adaptive design to quickly identify which treatments work best. Up to 2,250 participants will be enrolled …

This early study tests whether using focused ultrasound (NaviFUS) to temporarily open the blood-brain barrier can help the drug Avastin work better against recurrent glioblastoma, an aggressive brain cancer. Ten adults whose cancer has returned after standard treatment will recei…

This study tests a new approach using immune cells from healthy donors, engineered to recognize and attack cancer cells. The target is chosen based on each participant's tumor profile. The trial includes 85 adults with advanced solid tumors that have not responded to standard tre…

This phase 2 trial tests a combination of a targeted cancer drug (cetuximab) given directly into the brain's blood vessels along with repeat radiation for people whose brain cancer has come back. The study includes 37 adults with specific types of aggressive brain tumors that ove…

This early-stage trial tests a new treatment called CARv3-TEAM-E T cells for people with glioblastoma, a serious brain cancer that has come back. The therapy uses the patient's own immune cells, modified in a lab to better attack the cancer, and is given directly into the brain f…

This phase 2 trial tests whether sitagliptin, a diabetes drug, can improve the immune system's ability to fight glioblastoma, an aggressive brain tumor. The study will enroll 48 adults with progressive grade 4 gliomas who are scheduled for tumor removal surgery. Some participants…

This Phase 3 trial compares the drug niraparib to the standard chemo temozolomide in 450 adults with newly diagnosed, aggressive glioblastoma that has a specific genetic marker (MGMT unmethylated). Participants take the assigned drug daily during radiation, then continue until th…

This early-phase trial tests two experimental drugs, ABBV-637 and ABBV-155, alone or together with ERAS-801 in people whose glioblastoma has come back after standard treatment. About 60 adults with a specific genetic marker (EGFR amplification) will take part. The main goal is to…

This study tests if using focused ultrasound (sound waves) can help the drug Avastin work better for people with recurrent glioblastoma, an aggressive brain cancer. About 32 adults will either get Avastin alone or Avastin plus the ultrasound treatment. The goal is to see if the c…

This study tests an experimental treatment for glioblastoma, a serious brain cancer. It combines a drug (5-ALA) with a special ultrasound device that aims to target cancer cells without surgery. About 103 people who have completed standard therapy will be randomly assigned to get…

This study tests a two-step treatment for people whose brain tumors (gliomas) have come back after standard therapy. First, a laser is used to heat and destroy the tumor, followed by a short course of targeted radiation. The goal is to control the tumor safely and delay further g…

This early study tests if a piece of belly tissue placed in the brain during surgery can safely bypass the blood-brain barrier in people with recurrent glioblastoma, an aggressive brain cancer. Ten adults will be followed for 6 months to check for side effects like rapid tumor gr…

This early-stage trial tests a new treatment for glioblastoma, an aggressive brain cancer. Researchers take a patient's own immune cells, modify them in the lab to better recognize and attack the tumor, and then infuse them back. The study involves 20 adults whose tumors have a s…

This early-phase trial is testing whether adding the drug ibrutinib to a chemo-immunotherapy regimen can safely help children and young adults (ages 6–25) with brain cancers that have come back or not responded to standard treatment. The study combines ibrutinib with indoximod an…

This study offers continued access to an experimental drug (NBM-BMX) plus standard chemotherapy (temozolomide) for people with newly diagnosed glioblastoma, a serious brain cancer, who completed a previous trial. About 15 participants will be monitored for long-term safety and ho…

This study tests a new drug, TLX101-Tx, that delivers radiation directly to glioblastoma cells. It is combined with standard chemotherapy (lomustine) and compared to chemotherapy alone in 50 adults whose brain cancer has returned after initial treatment. The goal is to see if the…

This early-phase study tests a new drug called FS-8002 in 66 people with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it helps control the cancer. Participants will receive FS-…

This study tests an experimental drug called ONC206, alone or with radiation, in children and young adults with diffuse midline glioma (a tough-to-treat brain tumor) or other recurrent brain cancers. The goal is to find the best dose and see if it's safe. The drug works by stress…

This study is for children and teens (ages 3 to 18) with certain solid tumors that have returned or not responded to standard treatment. The tumors must have a specific marker called SSTR. The study combines two drugs: Lutathera (a radioactive drug that targets SSTR) and Olaparib…

This early-phase trial tests two existing drugs—senicapoc and perampanel—alone and together in 36 adults with newly diagnosed glioblastoma, the most common and aggressive brain cancer. The goal is to find safe doses and see how well the drugs reach the brain and affect tumor cell…

The BELGICA trial is testing whether a smaller radiation target in glioblastoma patients can reduce side effects and improve quality of life without shortening survival. About 347 adults with newly diagnosed glioblastoma will be randomly assigned to standard or reduced radiation …

This early-stage trial tests a new drug called 212Pb-DOTAM-GRPR1, which delivers a tiny dose of radiation directly to cancer cells that have a specific marker (GRPR). The study will include 48 adults with advanced cancers such as prostate, breast, lung, colon, cervical, or brain …

This Phase 3 trial tests whether an implanted ultrasound device, SonoCloud-9, can temporarily open the blood-brain barrier to let more carboplatin chemotherapy reach recurrent glioblastoma tumors. About 560 participants will receive either the device plus carboplatin or standard …

This study tests a different way of giving the chemotherapy drug temozolomide to elderly patients (65+) with a tough-to-treat type of brain cancer called glioblastoma. The tumor has a marker (unmethylated MGMT) that usually makes standard chemo less effective. Researchers hope th…

This phase II trial tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy (temozolomide) helps people with a returning type of brain cancer called glioblastoma live longer. The study plans to enroll 120 adults whose tumor has come back after init…

This early-stage trial is testing an experimental drug called RSC-1255, taken alone or with hydroxychloroquine, in people with advanced solid tumors (such as lung, colon, or pancreatic cancer) that have stopped responding to standard treatments. The study has two parts: first, fi…

This early-phase trial tests a new treatment for adults with recurrent glioblastoma, an aggressive brain cancer. The treatment uses specially engineered immune cells (CAR-NK cells) designed to recognize and attack tumor cells. Up to 36 participants will receive the cells directly…

This early-phase trial is testing whether sitagliptin, a drug used for diabetes, can help treat recurrent grade 4 glioma (a severe brain cancer) when combined with the standard drug bevacizumab. The study involves 45 adults whose cancer has returned after initial treatment. Resea…

This study tests a drug called PLX038 in adults with brain or spinal cord tumors, including those with changes in the MYC or MYCN genes. The trial has two phases: first, finding the right dose, then checking if it works. Participants receive PLX038 intravenously every three weeks…

This phase II trial tests whether using a special PET scan (FDOPA-PET) to guide radiation therapy can help people with recurrent glioblastoma, an aggressive brain cancer. About 54 participants who have already had radiation will receive a more precise radiation boost to active tu…

This study tests a new surgical technique for people with glioblastoma, an aggressive brain cancer. Surgeons place a piece of the patient's own tissue (from the scalp or skull lining) into the area where the tumor was removed. This tissue flap may help bypass the blood-brain barr…

This early-phase study tests a new treatment for people with a recurring type of brain cancer called glioblastoma. The treatment uses specially designed immune cells (NK-92/5.28.z) that are injected directly into the brain to attack cancer cells. The main goals are to check safet…

This study tests a combination of drugs (nogapendekin alfa inbakicept, PD-L1 t-haNK, and bevacizumab) with or without tumor treatment fields in people whose glioblastoma has returned or worsened. The goal is to see if these treatments can safely control the cancer and improve sur…

This early-phase study tests whether using Tumor Treating Fields (TTFields) before surgery and radiation is safe for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 42 participants will wear a device that sends electric fields to the tumor, then under…

This study tests whether adding the chemotherapy drug capecitabine to the standard treatment temozolomide can help people with newly diagnosed glioblastoma (a fast-growing brain cancer) live longer without their cancer getting worse. About 67 adults who have completed initial rad…

This study tests a drug called ivonescimab in 45 adults whose glioblastoma brain tumor has returned after standard treatment. Phase 1 finds the safest dose, and Phase 2 checks if that dose can control the tumor. The goal is to manage the disease, not cure it.

This study tests whether adding an immunotherapy drug (pembrolizumab) to standard treatment (tumor-treating electric fields plus chemotherapy) helps people with newly diagnosed glioblastoma live longer. About 741 adults who have had surgery for glioblastoma will be randomly assig…

This early-phase study tests a new drug called FT536 for adults with a severe type of brain cancer (WHO Grade 4 astrocytoma) that has come back. The drug is injected directly into the tumor during surgery. The main goal is to check safety and find the right dose in 9 participants…

This early-stage study tests whether a special MRI scan (CEST-EPI) can help surgeons see and remove more aggressive brain tumor (glioblastoma) cells that standard scans miss. About 18 adults with newly diagnosed or recurrent glioblastoma will have surgery guided by this pH-sensit…

This study tests whether combining three drugs (trimipramine, atezolizumab, and bevacizumab) can help control recurrent glioblastoma, an aggressive brain cancer. About 59 participants will receive the treatment for up to 2 years, with some undergoing surgery to measure drug level…

This study tests a new drug, VRT106, in 42 adults whose glioblastoma (a fast-growing brain tumor) has returned or worsened. The main goals are to check safety, find the best dose, and see if it helps shrink tumors or extend life. Participants receive VRT106 by injection and are c…

This program provides gallium maltolate (GaM) to adults aged 18 and older with glioblastoma that has returned or is not responding to standard treatments. The goal is to offer a possible treatment option when no others are available. Patients must be able to swallow capsules and …

This study tests a new approach for people with a newly diagnosed aggressive brain cancer called glioblastoma. The treatment delivers a drug called cetuximab directly to the brain tumor through a thin tube in an artery, after temporarily opening the blood-brain barrier. The goal …

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a fast-growing brain tumor) has returned after standard treatment. The drugs are temozolomide (a chemotherapy pill given daily at low doses) and abexinostat (an experimental drug that may …

This study tests methimazole, a drug normally used for thyroid problems, in people with progressive glioblastoma (a fast-growing brain tumor). Researchers want to see if it can help control the disease and how safe it is. About 19 adults will receive different doses to find the b…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This early-stage study tests whether a new treatment using a patient's own immune cells, engineered to attack two specific targets on glioblastoma cells, is safe. It involves 9 adults with a newly diagnosed, aggressive form of glioblastoma who have completed radiation but show no…

This early-stage trial tests a new treatment for children and young adults up to age 21 with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a pro…

This early-phase study is testing whether giving the immunotherapy drug ipilimumab before standard surgery and chemoradiation is safe and can help control glioblastoma, a fast-growing brain cancer. About 16 adults with newly diagnosed glioblastoma will receive up to two doses of …

This study tests an experimental drug called BDTX-1535 in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have certain changes in the EGFR gene. The drug aims to block a growth signal that these tumors rely on. The trial first measures how much drug r…

This early study tests whether adding the drug azeliragon to standard chemoradiotherapy can help the immune system fight glioblastoma, an aggressive brain cancer. About 12 adults with newly diagnosed glioblastoma will receive either standard treatment or standard treatment plus a…

This early-stage study tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and check for side effects. About 102 participants will take the drug once or several times a week.

This study tests a new way to treat glioblastoma, a fast-growing brain tumor. Right after removing the tumor, doctors give a single dose of targeted radiation inside the cavity using a special balloon device. Then patients receive standard chemotherapy and radiation. The goal is …

This program provides early access to an experimental drug called AVM0703 for people with various solid tumors and blood cancers, including hard-to-treat types like glioblastoma and metastatic breast cancer. It is available to patients in the US whose doctor requests it. So far, …

This study tests whether a daily egg powder enriched with a natural protein called antisecretory factor can help people with newly diagnosed glioblastoma live longer. About 300 participants will receive either the active egg powder or a placebo alongside standard chemotherapy and…

This study tests several new drugs, alone or with standard chemotherapy, for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 460 participants will receive one of the experimental treatments to see if they live longer compared to standard therapy. The …

This early-phase trial tests whether the drug troriluzole can affect brain activity and reduce harmful glutamate levels in people with recurrent glioblastoma, an aggressive brain cancer. About 27 adults whose tumor has returned after standard treatment will receive the drug befor…

This early-phase study tests a new drug called RZ-001 combined with valganciclovir in people with glioblastoma, an aggressive brain cancer. The goal is to find a safe dose and see if the treatment can shrink tumors or help people live longer. About 43 adults with a specific genet…

This early-phase study tests a new approach for people with recurrent high-grade astrocytomas, a type of aggressive brain cancer. Participants will receive a special virus injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the …

This early-phase study tests a drug called WSD0628 combined with radiation therapy for people whose high-grade glioma (a type of brain tumor) has come back after prior treatment. The main goal is to find the safest dose and check for side effects. About 94 adults with specific br…

This early-phase study tests an experimental drug called CUE-102 in 18 adults whose glioblastoma (a type of brain cancer) has come back after initial treatment. The main goal is to find the safest dose and check for side effects. Participants must have a specific genetic marker (…

This program provides the experimental drug ulixertinib to people with advanced solid tumors that have certain gene mutations (MAPK pathway). It is for patients who have not responded well to or have run out of standard treatments. The goal is to control the disease and possibly …

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This early-phase study tests a new treatment for aggressive brain tumors (glioblastoma and pediatric high-grade gliomas). The therapy uses a patient's own immune cells, modified to target a protein called CD70 on tumor cells and to better reach the brain. The main goals are to ch…

This study tests a two-step treatment for people newly diagnosed with high-grade gliomas, a fast-growing type of brain tumor. First, a laser is used to heat and destroy tumor tissue. Then, a short course of radiation is given to kill remaining cancer cells. The goal is to safely …

This study tests whether adding two different drug combinations after radiation can help children and young adults (up to age 21) with high-grade gliomas, including DIPG, live longer. One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The go…

This study tests a combination of three drugs (pembrolizumab, olaparib, and temozolomide) in people whose glioblastoma brain tumor has come back after prior treatment. The goal is to see if the drugs can boost the immune system's attack on the tumor and slow or stop its growth. A…

This study tests a new treatment for aggressive brain tumors (glioblastoma) that uses a radioactive substance attached to a targeting molecule. The therapy is given directly into the tumor area after standard treatments like surgery and chemotherapy. The goal is to see if it can …

This early-stage trial tests a new drug called Peposertib combined with radiation and chemotherapy for people with a fast-growing brain cancer (glioblastoma). The goal is to find the best dose and see if the drug can reach the brain to help kill tumor cells. About 29 adults with …

This study tests whether giving a higher dose of radiation along with a drug called bevacizumab can help people with a fast-growing brain tumor (glioblastoma) live longer. About 146 adults aged 18 to 70 with a specific type of glioblastoma will receive the treatment. The goal is …

This study tests whether adding silibinin (a milk thistle extract) to standard chemoradiation and maintenance chemotherapy can delay tumor growth in people with a specific type of newly diagnosed glioblastoma. About 110 adults whose tumors have a certain protein marker (STAT3-pos…

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This study is testing a new radioactive imaging agent that targets a protein called LRRC15, found on many cancer cells. Researchers will use PET scans to see if this agent can better detect and stage cancers like pancreatic, breast, lung, and others. The trial includes 26 healthy…

This study tests whether a special brain scan (PET-MRI) done within 48 hours after glioblastoma surgery is safe and practical. Fifteen adults who just had their first surgery for a suspected glioblastoma will get this scan, which uses a radioactive tracer and contrast dye. The go…

This study tests a new technique called sonobiopsy that uses focused ultrasound to release DNA from brain tumors into the bloodstream, making it easier to detect and analyze the tumor's genetic makeup through a simple blood test. The goal is to improve diagnosis and treatment pla…

This study tests a special dye that makes brain tumor cells glow under a camera during surgery. The goal is to help surgeons see and remove more of the tumor while sparing healthy brain tissue. About 46 adults with malignant glioma or vestibular schwannoma will receive the dye be…

This study tests a device called the CONVIVO system, which acts like a high-powered microscope during brain tumor surgery. It helps surgeons tell the difference between normal and abnormal tissue right away. About 30 adults with various brain tumors will take part. The goal is to…

This study is testing whether the blood thinner apixaban can safely prevent blood clots in people newly diagnosed with a fast-growing brain tumor called grade 4 glioma. About 40 adults will take apixaban while receiving standard radiation and chemotherapy. The main goal is to see…

This study tests whether proton beam radiation causes fewer side effects than standard photon radiation in people with glioblastoma, an aggressive brain cancer. About 326 patients will receive either proton or photon therapy alongside standard care. The main goal is to see if pro…

This study tests a program called ICCAN that gives cancer patients extra help with social and economic needs, like finding resources and monthly check-ins. Researchers want to see if this support helps patients complete their cancer treatment and improves their quality of life, c…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study tests a new program called EASE, which uses a simple writing exercise to help adults with advanced cancer manage their fear of the future and related trauma symptoms. The study will include 250 people with advanced solid tumors, glioblastoma, or certain ovarian or lung…

This study tests whether a custom-made video, showing symptoms and side effects based on each patient's own brain scan, can lower anxiety for people with brain tumors and their caregivers during radiation treatment. About 117 patients with newly diagnosed glioma and their caregiv…

This study tests whether a 6-week occupational therapy group programme can improve quality of life and daily functioning in adults with primary brain tumours who are on active treatment. Participants are randomly assigned to either the group programme or usual care (written infor…

This trial is testing whether a personalized drug screening method can help people with a type of brain cancer called glioblastoma. Researchers will grow tumor cells from each patient in the lab and test different drugs to find the most effective ones. The study will compare surv…

This study will collect blood and tumor samples from 80 people with newly diagnosed glioblastoma to find biological markers that show whether a treatment called TTFields (tumor-treating fields) is working. The goal is to understand why some patients respond and others don't. Part…

This study is testing whether a monthly blood test can predict dangerous blood clots in people with certain cancers (lung, pancreatic, stomach, or brain). Cancer patients are at high risk for clots, which can be deadly. Researchers will follow 200 participants for 12 months, taki…

This study tests whether a substance called 5-ALA, already used during brain surgery to make tumor cells glow, can also be detected in blood or urine. Researchers hope this 'liquid biopsy' could help diagnose and monitor glioblastoma, the most common and deadly brain tumor, witho…

This study looks at whether surgery can help people whose glioblastoma has come back after initial treatment. 120 participants will be randomly assigned to either have surgery followed by second-line therapy, or to have second-line therapy alone. The goal is to see if surgery imp…

This study uses genetic testing of brain tumors from children, adolescents, and young adults (ages 1 to 39) with newly diagnosed high-grade glioma, including DIPG. The goal is to identify specific genetic changes in each tumor and then see if patients can join a treatment trial t…

This study compares two common methods of closing the skin after brain tumor surgery: a continuous stitch under the skin using absorbable thread versus separate stitches through the skin using non-absorbable thread. Researchers want to see which method leads to fewer wound proble…

This study looks at how much of the drug T-DXd enters brain tumors in people with HER2-positive brain cancers or glioblastoma. Thirty participants will receive T-DXd before surgery to remove a brain tumor, and researchers will measure drug levels in the tumor. The goal is to see …

This early-phase trial is testing two new antibody fragments that are designed to attach to a sugar molecule found on many solid tumors. The fragments are labeled with a radioactive tracer so they can be seen on PET/CT scans. The study aims to see where these fragments go in the …

This study collects and preserves glioblastoma tissue from 120 patients during standard surgery, along with blood samples. Researchers will analyze tissue from different tumor regions to understand its structure and genetics. The goal is to learn more about how glioblastoma works…

This early-phase study is testing whether a special egg yolk powder called Salovum® can reduce pressure and inflammation inside glioblastoma brain tumors. Ten adults with suspected glioblastoma will have probes placed during a biopsy to measure tumor pressure and fluid before and…

This study looks at whether MRI scans can help identify which glioblastoma patients are most likely to benefit from the drug bevacizumab. Researchers will analyze tumor tissue and imaging from 50 adults undergoing surgery for newly diagnosed or recurrent glioblastoma. The goal is…

This study looks at what factors—like genetics, immune system, and medical history—affect survival and quality of life in adults with glioblastoma, a severe brain cancer. About 200 participants will fill out an online survey and may provide a blood sample from home. The goal is t…

This study tests whether recording electrical activity in and around high-grade glioma tumors during surgery can help predict where the tumor will grow next. Ten adults with aggressive brain tumors will have standard surgery plus a small biopsy at recording sites. The goal is to …

This study looks at 100 adults with newly diagnosed glioblastoma, the most common and aggressive brain tumor. Researchers will measure certain proteins (MMP2 and MMP9) in blood and tumor tissue, and compare them with MRI scans. The goal is to better understand how these proteins …

This study watches 200 adults who have brain tumor surgery to see how often spinal fluid leaks happen, what makes them more likely, and how doctors treat them. The goal is to find ways to reduce these leaks and help patients recover faster.

This pilot study uses two types of PET scans and a powerful 7Tesla MRI to create a detailed metabolic picture of glioblastoma, an aggressive brain cancer. Researchers will compare scan results with tumor tissue analysis to better understand how the tumor uses energy. The goal is …

This study is testing a new approach to personalize treatment for people with a fast-growing brain tumor called glioblastoma. Researchers will use a lab test on tumor cells to see which drugs might work best for each patient. The goal is to find out if this method can help more p…

This study looks at whether certain brain chemicals can predict survival in people with glioblastoma (a fast-growing brain cancer) that has returned after standard treatment. Researchers will measure these chemicals with special scans 7 and 28 days after starting the drug bevaciz…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study tests whether three advanced MRI techniques can non-invasively visualize the immune cells and proteins surrounding glioblastoma tumors. Researchers aim to understand why some brain tumors are harder to treat. About 15 adults with suspected glioblastoma will have these …

This study is testing a small device called a microdialysis catheter that is placed in the brain during surgery for tumors like glioma or glioblastoma. The catheter collects fluid samples to measure biomarkers—natural substances that can show how severe the disease is. The goal i…