GLIOBLASTOMA

This study tests a combination of three drugs (pembrolizumab, olaparib, and temozolomide) in people whose glioblastoma brain tumor has come back after prior treatment. The goal is to see if this mix can shrink the tumor or slow its growth by boosting the immune system and damagin…

This program offers ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific gene changes (MAPK pathway mutations) and who have not responded to or exhausted other treatments. The goal is to provide compassionate access to possibly control the ca…

This study tests an experimental drug called BDTX-1535 in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have specific changes in the EGFR gene. The drug is designed to block a growth signal that these tumors rely on. The study has two parts: first, …

This early-phase study tests a new approach for people with recurrent high-grade brain tumors (astrocytomas). It combines a virus-based gene therapy with targeted radiation during surgery. The main goal is to find the safest dose and see if it boosts the immune system against the…

This phase 3 trial tests whether a device called SonoCloud-9 can temporarily open the blood-brain barrier, allowing more chemotherapy (carboplatin) to reach brain tumors in people with recurrent glioblastoma. About 560 participants will be randomly assigned to receive either carb…

This early-stage study tests a new treatment for people with a recurrent, aggressive brain cancer called glioblastoma. The treatment uses specially designed immune cells (NK-92/5.28.z) that are injected directly into the brain tumor during surgery. The main goals are to see if th…

This early-phase trial tests a new treatment called E-SYNC CAR T cells for people with a specific type of glioblastoma brain cancer. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack the tumor. About 20 adults will receive the cells a…

This trial is testing several new treatments at once for people with glioblastoma, a fast-growing brain cancer. It includes both newly diagnosed patients and those whose cancer has returned. The goal is to see which treatments help people live longer and control the tumor better.

This study tests an experimental drug called ONC206, alone or with radiation, in children and young adults with a rare and aggressive brain tumor called diffuse midline glioma (DMG) or other recurring brain cancers. The goal is to find the best dose and see if it is safe. ONC206 …

This early-stage study tests a device that uses sound waves to help a standard cancer drug reach the brain more effectively in people with recurrent glioblastoma, an aggressive brain tumor. Ten participants will receive the drug bevacizumab along with focused ultrasound to see if…

This early-phase study tests an experimental drug called CUE-102 in 18 adults whose glioblastoma (a type of brain cancer) has returned after initial treatment. The main goal is to check the drug's safety and find the best dose. Participants must have a specific genetic marker (HL…

This study tests whether combining an antidepressant (trimipramine) with two cancer drugs (atezolizumab and bevacizumab) can help people whose glioblastoma brain tumor has returned after standard treatment. About 59 participants will receive the drug combination for up to 2 years…

This study tests whether adding silibinin (a milk thistle extract) to standard chemoradiation and maintenance therapy can delay cancer growth in people with a specific type of newly diagnosed glioblastoma. About 110 adults whose tumors show a STAT3 protein marker will receive eit…

This study tests whether giving higher doses of radiation along with the chemotherapy drug temozolomide can better control certain aggressive brain tumors (IDH wildtype gliomas). About 40 adults with these tumors will receive the intensified treatment. The goal is to see if this …

This study tests a gene therapy (HSV-tk) plus valacyclovir alongside radiation and chemotherapy for people newly diagnosed with glioblastoma or anaplastic astrocytoma, two aggressive brain cancers. The goal is to see if this combination improves survival and slows tumor growth. A…

This early-stage study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers like prostate, breast, lung, or colon cancer that have come back or spread. The main goals are to find a safe dose and ch…

This study tests a new treatment for glioblastoma, a serious brain cancer. It combines a drug (5-ALA) with a special ultrasound device that sends sound waves into the brain to target cancer cells. About 103 people who have finished standard therapy will be randomly assigned to ge…

This early-stage trial tests a treatment made from a child's own immune cells, modified to target a protein called B7-H3 found on many brain tumors. The cells are delivered directly into the brain through a small tube. The study includes up to 48 children and young adults with ce…

This early-phase study tests whether adding the drug azeliragon to standard chemoradiotherapy can help the immune system fight glioblastoma, an aggressive brain cancer. About 12 adults with newly diagnosed, residual tumors will receive either standard treatment or standard treatm…

This early-phase trial tests whether adding the drug ibrutinib to a chemotherapy and immunotherapy combination can help children and young adults (ages 6–25) with brain cancers that have come back or not responded to standard treatment. The study aims to find the safest dose of i…

This study tests a combination of drugs (nogapendekin alfa inbakicept, bevacizumab, and immune cells called PD-L1 t-haNK) with or without tumor treatment fields (a device that uses electric fields to disrupt cancer growth) in people whose glioblastoma has come back or worsened. T…

This early-phase study tests a new drug called RSC-1255, alone or with hydroxychloroquine, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) who have run out of standard treatments. The goal is to find a safe dose and see if the drug can control the di…

This study tests several new drugs, alone or with standard chemotherapy, for people with newly diagnosed glioblastoma, an aggressive brain cancer. About 460 participants will receive one of the experimental treatments or standard care. The goal is to see if these combinations hel…

This study tests a two-step treatment for people whose brain tumors (gliomas) have returned after standard care. First, a laser is used to heat and destroy tumor tissue, followed by a short course of targeted radiation. The goal is to see if this approach is safe and can help con…

This study tests a drug called WSD0628 given together with radiation therapy for people whose high-grade glioma (a type of brain tumor) has come back after previous treatment. The main goals are to find the safest dose and to see how well the combination works against the tumor. …

This early-phase trial tests the drug troriluzole in 27 adults with recurrent glioblastoma, a type of aggressive brain tumor. Participants take the drug before surgery to see how it affects brain activity and glutamate levels in the tumor. The goal is to gather information for fu…

This study tests a new way to treat glioblastoma, an aggressive brain cancer. Right after removing the tumor, doctors deliver a single dose of radiation directly to the surgical cavity using a special balloon device. Then patients receive standard chemotherapy and radiation. The …

This study tests a drug called ivonescimab in 45 adults whose glioblastoma has returned after standard treatment. Phase 1 finds the safest dose; Phase 2 checks if that dose can control the tumor. The goal is to manage the disease, not cure it.

This study tests a new drug, niraparib, against the standard treatment temozolomide in adults with a newly diagnosed, hard-to-treat type of glioblastoma (a brain cancer). About 450 participants will be randomly assigned to one of the two drugs, taken daily during radiation. The m…

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers, including glioblastoma, breast cancer, and lymphoma. It is available to US patients whose doctors request it. Side effects are mostly mild, such as itchin…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This study is testing a new radioactive dye for PET scans that targets a protein called LRRC15, found on many aggressive tumors like pancreatic, breast, lung, and brain cancers. About 26 people with suspected or confirmed cancer, plus some healthy volunteers, will receive the dye…

This study tests whether the blood thinner apixaban can safely prevent blood clots in people with newly diagnosed grade 4 brain tumors (glioblastoma or astrocytoma). About 40 participants will take apixaban while undergoing standard radiation and chemotherapy. The main goal is to…

This study tests whether proton beam radiation causes fewer side effects than standard photon radiation in people with glioblastoma, a serious brain cancer. About 326 adults who need radiation after surgery or biopsy will be randomly assigned to one of the two types. The main goa…

This study tests a 6-week occupational therapy group program for adults with primary brain tumors who are on active treatment. The program covers fatigue management, cognitive strategies, relaxation, and peer support. Researchers want to see if it improves quality of life and dai…

This study compares two common methods of closing the skin after brain tumor surgery: running stitches (absorbable) versus individual stitches (non-absorbable). Researchers want to see which method leads to fewer wound problems like infection or fluid leaks. About 382 adults havi…

This study tests a new ultrasound system (SonoClear®) that mimics brain tissue to improve image quality during brain tumor surgery. About 15 adults with glioma will have ultrasound images taken with both the new system and standard saline solution, comparing clarity and safety. T…

This study looks at MRI scans and a protein called decorin in 50 adults with glioblastoma, a serious brain cancer. The goal is to find out which patients might respond better to a common but expensive drug called bevacizumab. Participants will have their tumors analyzed after sur…

This study looks at whether having surgery to remove a returning glioblastoma brain tumor helps people live longer and feel better. About 120 adults whose cancer came back after standard treatment will be randomly assigned to either have surgery plus follow-up therapy or just fol…

This study tests a new imaging agent that uses special antibodies to highlight tumors on PET/CT scans. About 32 adults with various solid cancers will receive a single injection of the agent to see where it goes in the body and how safe it is. The goal is to learn if this method …

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks occur, what makes them more likely, and how doctors treat them. The goal is to find ways to prevent leaks and help patients heal faster.

This study is testing a small probe called a microdialysis catheter that is placed in the brain during surgery for tumors like glioblastoma or metastatic cancer. The probe collects fluid samples to measure chemicals (biomarkers) in and around the tumor. The goal is to see if this…

This study is looking for biological markers that can predict if a glioblastoma patient will survive at least 6 months after treatment with the drug bevacizumab. Researchers will use special brain scans to measure certain chemicals in the tumor. The goal is to identify which pati…

This study tests whether testing a patient's own tumor cells in a lab to find the most effective drugs can improve survival for people with a newly diagnosed, aggressive brain cancer called glioblastoma. About 240 adults aged 18-75 will take part. Half will receive standard treat…

This study looks at the genetic makeup of high-grade brain tumors in children, teens, and young adults (ages 1 to 39) who are newly diagnosed. The goal is to find specific genetic changes that could make them eligible for future treatment studies. No treatment is given in this st…

This early-phase study is testing whether a powder made from egg yolks (Salovum) can reduce pressure and inflammation inside glioblastoma brain tumors. Ten adults with suspected glioblastoma will have probes placed during a biopsy to measure tumor pressure and fluid before and af…

This study follows 200 adults with glioblastoma, a severe brain cancer, to understand how genetics, immune system, and personal history affect survival and quality of life. Participants fill out online surveys and may provide a blood sample from home. The goal is to gather inform…

This early-phase study tests if recording electrical activity in and around high-grade glioma tumors during surgery is safe and feasible. Researchers will take small biopsies from recording sites and track tumor progression on follow-up MRI. Ten adults with suspected or recurrent…

This study is testing whether an artificial intelligence (AI) tool can help connect cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers and use the AI to suggest trials based on their tumor's genetic markers. The goal i…