GLIOBLASTOMA

This study tests a new approach called pharmacoscopy for people with brain tumors that have not responded to standard treatments. The method uses a lab test on a patient's own tumor cells to find which drugs might work best for them. The goal is to see if this personalized way of…

This early-phase trial tests whether sitagliptin, a diabetes medicine, can boost the immune system to fight recurrent grade 4 gliomas (a fast-growing brain cancer). About 45 adults whose cancer has returned after standard treatment will receive sitagliptin combined with bevacizum…

This early-stage study tests an experimental pill called GLIX1 in 30 adults whose high-grade glioma (a fast-growing brain tumor) has come back or worsened after standard treatments. The main goals are to find a safe dose and check for side effects. Participants take GLIX1 daily u…

This study tests giving chemotherapy before radiation for high-grade gliomas, a type of aggressive brain tumor. The goal is to make MRI scans easier to read and to screen new drugs more effectively. About 70 adults aged 18 to 80 with residual tumor after surgery will receive temo…

This study tests whether adding an experimental drug (ADI-PEG 20) to standard radiation and chemotherapy can help children, teens, and young adults with a newly diagnosed aggressive brain tumor called high-grade glioma. About 97 participants will receive the drug combination to s…

This early-phase trial tests a personalized vaccine called Bvax, made from a patient's own tumor, alongside standard chemoradiation for newly diagnosed glioblastoma. The study aims to see if the vaccine is safe and feasible in 25 participants. It is not a cure, but a way to poten…

This early study tests if a new device can safely collect small fluid samples from the brain during planned surgery for glioma (a type of brain tumor) or epilepsy. Six participants will have the device placed temporarily during their operation. The goal is to see if the procedure…

This very early (Phase 0) study will give a gallium-based drug by mouth to 8 people with recurrent glioblastoma before surgery. The main goal is to measure how much gallium gets into the tumor tissue compared to untreated samples. This is not a treatment study—it is designed to g…

This study tests whether using MRI scans to plan radiotherapy is better than using CT scans alone. Researchers will work with up to 150 cancer patients and 15 healthy volunteers to see if MRI can make treatment more precise and reduce side effects. The goal is to improve how tumo…

This study will follow 100 adults with glioblastoma, a serious brain cancer, to learn which factors (like surgery type, tumor features, and patient health) are linked to longer survival. Researchers will collect data from hospitals in Europe and the U.S. but will not test any new…

This study looks at 30 adults newly diagnosed with glioblastoma, an aggressive brain tumor. Researchers will compare special MRI scans (MRS) with blood tests before and after standard treatment. The goal is to find patterns that could help doctors better understand the tumor and …

This early safety study tests a special MRI that uses pH (acid levels) to better show the edges of glioblastoma, a hard-to-treat brain tumor. The goal is to help surgeons remove more of the tumor while keeping patients safe. Only 12 veterans with suspected or recurrent glioblasto…