GLIOBLASTOMA

This phase 3 trial tests whether a special MRI scan (called CEST MRI) can help surgeons remove more glioblastoma tissue than standard MRI-guided surgery. Standard MRI often misses tumor cells that don't light up with contrast dye. CEST MRI uses pH differences to spot these hidden…

This early-phase trial tests a new personalized vaccine called Bvax, made from each patient's own cells, combined with standard chemoradiation for newly diagnosed glioblastoma. The study will enroll 25 people to check safety and see if the vaccine helps control the cancer. It is …

This study tests a method called pharmacoscopy, where a patient's tumor tissue is analyzed in the lab to find which drugs might work best for them. The goal is to see if this personalized approach is feasible for people with brain tumors that have not responded to standard treatm…

This phase II trial tests a personalized dendritic cell vaccine (ZSNeo-DC1.1) combined with standard chemotherapy (temozolomide) in 78 adults with newly diagnosed glioblastoma. Participants receive the vaccine as shots during chemo after surgery and radiation. The goal is to see …

This study tests a new way to deliver radiation for diffuse gliomas, a type of brain tumor. Instead of a fixed dose, the radiation plan is adjusted mid-treatment based on MRI and PET scans, with help from artificial intelligence. The goal is to hit resistant tumor areas harder wh…

This early-phase study tests a new drug called MT-125 alongside standard chemoradiation in people newly diagnosed with a specific type of glioblastoma (MGMT methylated). The goal is to find a safe dose and see how well the body handles it. About 36 adults will take part, with the…

This study tests a new approach for recurrent glioblastoma, an aggressive brain cancer. Doctors will use a laser to heat and destroy the tumor, then give an immunotherapy drug called cemiplimab to help the immune system fight any remaining cancer cells. About 99 participants will…

This early-phase study tests whether combining focused ultrasound with the immunotherapy drug pembrolizumab is safe and feasible for people with recurrent glioblastoma, a severe brain cancer. Only 8 participants with a specific genetic feature (mismatch repair deficiency) will be…

This study tests whether adding a drug called ADI-PEG 20 to standard radiation and chemotherapy can help children, teens, and young adults with newly diagnosed high-grade glioma (a fast-growing brain tumor). About 97 participants will receive the combination therapy. The goal is …

This study tests two experimental drugs, CTX-009 and CTX-471, in people whose glioblastoma has returned after standard treatment. The goal is to see if these drugs are safe and can help control the tumor or extend survival. About 54 participants will receive either CTX-009 alone …

This phase 2 trial tests whether placing tiny chemotherapy-releasing seeds directly into the brain after tumor removal can help control glioblastoma, an aggressive brain cancer. About 147 adults with either recurrent or newly diagnosed glioblastoma will receive the seeds plus sta…

This phase II trial tests whether vortioxetine, a drug currently used for depression, can help people with newly diagnosed glioblastoma. The study will enroll 78 adults and measure if the drug extends the time before the cancer worsens. Vortioxetine was selected because lab tests…

This early-stage study tests a fluorescent dye called panitumumab-IRDye800 to see if it is safe and can help surgeons spot brain tumors during surgery. The dye attaches to a protein found on many cancer cells and glows under a special camera. About 30 adults with brain lesions (s…

This early-stage study tests whether a special MRI that highlights acidic areas can help surgeons see and remove more of an aggressive brain tumor called glioblastoma. The study involves 12 VA patients with newly diagnosed or recurrent glioblastoma. The main goal is to check if t…

This study will collect blood and tumor samples from 45 adults with glioblastoma, a serious brain cancer, to understand why it often returns after treatment. Researchers will look at molecular, immune, and metabolic changes in the samples. The goal is to find new ways to target t…

This early-stage trial will test whether an oral drug called gallium maltolate can reach brain tumors in people with recurrent glioblastoma. Eight participants will take the drug for about two weeks before surgery, and researchers will measure gallium levels in the removed tumor …

This study tests whether special MRI scans can spot where brain tumors have spread into nearby healthy tissue, which standard scans miss. About 20 adults with suspected high-grade glioma will get extra scans before surgery. The results will be compared to tissue samples to see if…

This early study tests whether a small device can safely collect fluid from the brain during planned surgery for glioma or epilepsy. Six participants will have the device placed temporarily during their operation. The goal is to see if the device works and is safe, not to treat t…

This study looks at how the immune system changes in people with glioblastoma, an aggressive brain cancer, after they have surgery and chemotherapy. Researchers will take blood samples over six months to measure immune cells and signals. The goal is to understand the body's immun…

This study will follow 50 adults with glioblastoma, an aggressive brain cancer, to see how the amount of tumor removed during surgery affects how long they live. All patients will receive standard radiation and chemotherapy after surgery. The goal is to better understand which su…

This study looks at 30 adults newly diagnosed with glioblastoma, a serious brain cancer. Researchers will compare special MRI brain scans with blood tests to find patterns that might help understand the tumor better. The goal is to gather knowledge, not to test a treatment.

This study uses special brain scans to understand how glioblastoma tumors disrupt brain networks and cause thinking problems. Researchers will scan 80 adults before and after surgery to see how the tumor changes brain activity and connections. No new treatment is being tested; th…

This study tests giving chemotherapy before radiation for people with high-grade gliomas, a type of aggressive brain tumor. The goal is to see if this approach works well and makes MRI scans easier to read, since radiation can change how the brain looks. About 70 adults aged 18-8…

This study tests whether using MRI scans to plan radiotherapy is better than using CT scans alone. Researchers will work with up to 150 cancer patients and 15 healthy volunteers to see if MRI can make treatment more precise and reduce side effects. The goal is to improve how tumo…

This early-phase trial will test how Acetadote, a drug that affects cell damage, changes metabolism in people with newly diagnosed glioblastoma. Ten participants will receive Acetadote before surgery, and researchers will use MRI scans and tumor tissue analysis to measure metabol…

This study will follow 100 adults with glioblastoma, an aggressive brain tumor, to understand which factors influence survival and quality of life. Researchers will collect data on patient characteristics, imaging, surgery type, and outcomes. The goal is to identify the best surg…