GLIOBLASTOMA

This early-stage study tested a new mRNA vaccine (CVGBM) in 37 people with a fast-growing brain cancer called glioblastoma. Participants received the vaccine after surgery and radiation. The main goal was to check safety and find the best dose, while also watching for any signs t…

This study looked at whether adding a metabolic therapy program (fasting and a ketogenic diet) to standard treatment (chemotherapy and radiation) is safe and feasible for people with glioblastoma, a very aggressive brain cancer. The approach aims to starve cancer cells by lowerin…

This study tested a new approach for glioblastoma, an aggressive brain cancer. During surgery to remove the tumor, doctors used a special light therapy (photodynamic therapy) with increasing light doses to see if it was safe. The goal was to improve the standard treatment of surg…

This early study tested whether a device using focused ultrasound can safely open the blood-brain barrier in 3 patients with aggressive brain cancer (glioblastoma) while they received standard chemotherapy. The goal was to see if this approach could allow more chemo to reach the …

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced solid tumors (including breast, ovarian, stomach, colorectal, brain, bile duct, and pancreatic cancers) that had stopped responding to standard treatments. The goal was to see …

This study tested a drug called VAL-083 combined with standard radiation in 29 adults with a newly diagnosed, aggressive brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to find the safest dose and see if the combination shrinks tum…

This early-phase trial tested the safety of adding two drugs—pembrolizumab and vorinostat—to standard chemotherapy and radiation for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study enrolled 21 adults with good overall health. The main goal was to f…

This study tested a personalized immunotherapy for people with newly diagnosed glioblastoma, an aggressive brain cancer. Doctors took patients' own immune cells, trained them to recognize the tumor, and injected them back to help the body fight the cancer. The goal was to see if …

This study tested a new way to plan surgery for glioblastoma, the most common and aggressive brain cancer. Doctors used an AI model that predicts where the tumor is likely to come back, allowing them to remove extra tissue around the main tumor. The goal was to see if this approa…

This study tested whether adding a special light therapy during surgery is safe and doable for people with glioblastoma, an aggressive brain cancer. Ten adults who were already scheduled for surgery to remove their tumor received the extra light treatment. The main goal was to se…

This study tested whether adding an immune cell therapy called Immuncell-LC to standard chemotherapy (temozolomide) helps people with newly diagnosed glioblastoma, an aggressive brain cancer. 180 adults in Korea took part. The goal was to see if the combination improved how long …

This early study tested a device called NaviFUS that uses focused ultrasound waves, combined with the standard drug bevacizumab, in 6 adults whose glioblastoma brain tumor had come back after prior treatment. The goal was to see if the combination was safe and could help control …

This study tested a new surgical technique that uses a special dye to make glioblastoma tumor cells glow during surgery, helping surgeons remove more of the tumor. 170 adults with newly diagnosed glioblastoma were randomly assigned to receive either this fluorescence-guided surge…

This study tested a mix of two immune-boosting drugs (retifanlimab and epacadostat) plus radiation and a targeted therapy (bevacizumab) in 51 adults with recurrent glioblastoma, an aggressive brain cancer. The goal was to see if this combination could help the immune system attac…

This study tested whether adding an immunotherapy drug (durvalumab) to targeted radiation therapy can help people with recurrent glioblastoma, an aggressive brain cancer. About 108 adults whose cancer returned after previous treatments took part. The goal was to see if the combin…

This study looked at whether a type of talk therapy called cognitive behavioral therapy for insomnia (CBT-I) can help people with brain tumors who have trouble sleeping. 70 adults with various brain tumors took part. The main goal was to see if the therapy was practical and helpf…

This study looked at whether video doctor visits (telehealth) work as well as in-person clinic visits for people with brain tumors (gliomas) who are taking chemotherapy pills. 30 patients took part, alternating between telehealth and in-person checkups. The goal was to see which …

This study involved 47 adults with newly diagnosed glioblastoma or gliosarcoma who had already completed standard surgery, chemotherapy, and radiation. Researchers gave them a combination of immunotherapy drugs (ipilimumab and nivolumab) along with the chemotherapy drug temozolom…

This study tested whether an expensive PET scan called 18F-FDOPA helps doctors choose better treatments for people with high-grade gliomas (a type of aggressive brain tumor). About 110 patients whose cases were discussed by a team of specialists were included. The main goal was t…

This study looked at medical records of 41 people who had surgery for aggressive brain tumors (high-grade gliomas). Surgeons sometimes use a special dye that makes tumor tissue glow, helping them tell it apart from healthy brain. The goal was to see if using this dye leads to mor…

This study looked at tumor tissue and blood samples from 141 adults with glioblastoma or other solid tumors. The goal was to understand how many cells can be collected and how well they survive, which may help doctors design better treatments in the future. No new therapies were …