GLIOBLASTOMA

This study tested a new surgical technique in 12 patients with newly diagnosed glioblastoma, an aggressive brain cancer. Surgeons placed a tissue flap from the scalp into the brain tumor cavity to bypass the blood-brain barrier, which normally blocks many treatments. The main goa…

This phase 2 trial tested a combination of two drugs (retifanlimab and epacadostat) plus radiation and bevacizumab in 51 patients with recurrent glioblastoma, an aggressive brain cancer. The goal was to see if this mix could boost the immune system to fight the tumor and improve …

This pilot study tested a device called NaviFUS that uses focused ultrasound to temporarily open the blood-brain barrier, combined with the drug bevacizumab (Avastin), in 6 patients with recurrent glioblastoma (a type of brain cancer). The goal was to see if the combination is sa…

This study tested whether a device called ExAblate, which uses focused ultrasound, can safely open the blood-brain barrier in 20 patients with high-grade glioma (a type of brain cancer). The goal was to allow standard chemotherapy drugs to better reach the tumor. Researchers chec…

This phase 1 trial tested a combination of two drugs, ASP8374 and cemiplimab (Libtayo), in 14 people with recurrent malignant glioma, a type of brain cancer. The study had two parts: first, finding the safest dose of ASP8374 when given with cemiplimab, and second, checking how th…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers like breast, ovarian, stomach, colorectal, brain, bile duct, or pancreatic cancer that had stopped responding to standard treatments. The goal was to see if the combo c…

This study tested a new treatment plan for people with a severe type of brain cancer called glioblastoma who are too sick for standard radiation. Doctors gave a combination of two drugs, bevacizumab and temozolomide, first to shrink the tumor and improve symptoms. The goal was to…

This study tested a drug called pamiparib, given with radiation therapy, for people with a fast-growing brain cancer called glioblastoma. It included 50 patients, some newly diagnosed and some whose cancer had come back. The goal was to see how much drug reaches the tumor and whe…

This small study tested whether a device using focused ultrasound can safely open the blood-brain barrier in patients with high-grade glioma (a type of aggressive brain cancer). The goal was to allow standard chemotherapy to reach the tumor more effectively. Only 3 patients were …

This phase 2 trial tested whether adding immune checkpoint inhibitors (nivolumab and ipilimumab) to standard chemotherapy (temozolomide) improves survival in 47 adults with newly diagnosed glioblastoma or gliosarcoma. Participants had their tumors surgically removed and completed…

This study tested whether a fluorescent dye called 5-ALA, taken before surgery, helps surgeons remove more of a glioblastoma brain tumor compared to using standard computer navigation. 170 adults with newly diagnosed glioblastoma were randomly assigned to receive either 5-ALA or …

This early-phase study tested a combination of tumor treating fields (a device that creates electric fields to disrupt cancer growth), stereotactic radiosurgery (precise radiation), and temozolomide chemotherapy in 12 adults with newly diagnosed glioblastoma. The main goal was to…

This phase 2 trial tested whether increasing the light dose during a special type of therapy called photodynamic therapy (PDT) is safe for people with glioblastoma, an aggressive brain cancer. Fourteen patients received a drug (5-ALA) before surgery, then a red laser was shone on…

This early-stage trial tested an mRNA vaccine called CVGBM in 37 people with a type of aggressive brain cancer called glioblastoma. The vaccine aims to help the immune system recognize and fight cancer cells. The main goal was to check safety and find the right dose, with some ea…

This study tested a new drug called VAL-083 combined with standard radiation for people with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker making it harder to treat. The goal was to find the safest dose and see if the drug helps shrink tumors. The …

This early-phase study tested a personalized vaccine made from a patient's own immune cells (dendritic cells) combined with standard chemotherapy (temozolomide) for adults with newly diagnosed glioblastoma, an aggressive brain cancer. Eleven patients who had most of their tumor r…

This study tested a personalized vaccine made from a patient's own tumor cells and immune cells (dendritic cells) for people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal was to see if the vaccine is safe and can help delay tumor growth. 76 participants …

This study tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation helps people with newly diagnosed glioblastoma, an aggressive brain cancer. About 60 participants received the combination to see if it improves survival and controls the d…

This early-phase study tested a new drug called TG02 in 71 patients with aggressive brain cancers (anaplastic astrocytoma or glioblastoma). The goal was to find the safest dose when combined with either radiation or chemotherapy. The study included newly diagnosed elderly patient…

This study tested whether adding an immune cell therapy called Immuncell-LC to standard chemotherapy (temozolomide) helps people with newly diagnosed glioblastoma, an aggressive brain cancer. 180 adults in Korea participated. The goal was to see if the combination slowed cancer g…

This study tested whether adding a metabolic therapy program (fasting and a ketogenic diet) to standard treatment (chemoradiation and chemotherapy) is safe and feasible for people with glioblastoma, an aggressive brain cancer. The approach aims to starve cancer cells by lowering …

This early-phase trial tested the safety of adding two drugs, pembrolizumab and vorinostat, to standard chemotherapy and radiation for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study enrolled 21 participants to find the highest safe dose of vorinos…

This study tested whether adding whole brain radiation and a drug called plerixafor to the usual chemotherapy and radiation could help people with a fast-growing brain tumor called glioblastoma. 21 patients took part. The goal was to see if the combination could delay tumor growt…

This early-phase study tested whether adding a 16-week ketogenic diet to standard radiation and chemotherapy is safe and doable for people with newly diagnosed glioblastoma, an aggressive brain cancer. Twenty-one adults followed personalized meal plans designed to keep their bodi…

This study tested whether adding the drug azeliragon to standard radiation and chemotherapy (temozolomide) is safe and shows early signs of working in people with newly diagnosed glioblastoma, a fast-growing brain cancer. 33 participants received the combination. The main goals w…

This study tested a new way to guide brain surgery for glioblastoma, a fast-growing and hard-to-treat brain cancer. Doctors used artificial intelligence (AI) to create maps showing where the tumor is likely to come back, then removed extra tissue beyond the visible tumor. The goa…

This early-phase study tested the safety and best dose of an experimental drug called ruxolitinib when added to standard brain cancer treatment (radiation and temozolomide) for people with newly diagnosed high-grade gliomas or glioblastoma. The study included 60 participants with…

This study tested a new drug (LY2157299) alone or combined with standard chemotherapy (lomustine) in 158 adults with recurrent glioblastoma, an aggressive brain cancer. The goal was to see if the new drug could help patients live longer or slow tumor growth compared to chemothera…

This pilot study tested whether a light-activated drug (5-ALA) could be safely used during brain surgery to treat glioblastoma, an aggressive brain cancer. Ten adult patients received this experimental therapy in addition to standard surgery and chemoradiation. The main goal was …

This study tested a new treatment for glioblastoma, a fast-growing brain cancer that had come back after initial therapy. The treatment combined a precise, high-dose radiation technique with an immunotherapy drug called durvalumab, which helps the immune system attack cancer cell…

This early-phase study tested a combination of two drugs (low-dose capecitabine and bevacizumab) in 12 people whose glioblastoma brain tumor had come back or continued growing despite prior treatment. The goal was to see if the drugs could reduce certain immune cells (MDSCs) that…

This study tested a new MRI contrast agent called RVP-001 in 18 adults with brain lesions from conditions like tumors or multiple sclerosis. The goal was to see if it is safe and can spot lesions as well as current gadolinium-based dyes, but without using gadolinium. Participants…

This study tested a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) in 70 people with brain tumors who also had trouble sleeping. The therapy involved six weekly group sessions delivered online. The main goal was to see if the approach was practical …

This study looked at whether video doctor visits (telehealth) work as well as in-person visits for people with brain tumors (gliomas) who are taking oral chemotherapy. 30 patients took part, alternating between telehealth and in-person checkups. The goal was to see which type of …

This study tested whether Ramipril, a common blood pressure medication, could help prevent memory loss in people with glioblastoma (a type of brain cancer) who are receiving radiation and chemotherapy. 75 participants took Ramipril during and for four months after treatment. Rese…

This study tested whether adding a combination of THC and CBD (cannabis compounds) to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. Thirty-three adults took part. The goal was to find the highest safe dose an…

This completed phase 1 trial measured how much lidocaine, a common pain reliever, reaches the tumor and blood in 12 adults undergoing surgery for glioblastoma. Researchers collected blood and tumor samples at multiple times to understand the drug's levels. The goal was to gather …

This study looked at brain tissue from 20 glioblastoma patients who had been treated with Tumor Treating Fields (TTFields) before they died. Researchers examined the tissue under a microscope to count active and inactive tumor cells. The goal was to understand how TTFields affect…

This study tested a special PET scan to measure oxygen levels inside glioblastoma brain tumors. Low oxygen (hypoxia) can make tumors harder to treat. The goal was to find the best way to use this scan to guide treatment. 14 adults with newly diagnosed glioblastoma took part.

This study developed and tested a program to help nurses better support relatives of patients with acquired brain injury or malignant brain tumors. The program included nurse training, a dialog tool, a peer support list, videos, and documentation guidelines. Researchers tested it…

This study looked at whether a blood test for a protein called hPG80 (progastrin) can help monitor high-grade brain tumors. Researchers took blood samples from 30 patients during their treatment and follow-up. The goal was to see if hPG80 levels change with tumor growth or after …

This study looked at how cancer affects a type of memory called prospective memory—remembering to do things in the future, like taking medication or keeping appointments. Researchers surveyed 426 people, including those with brain tumors, breast cancer, and healthy volunteers. Th…

This study looked at leftover tumor tissue and blood samples from 141 adults with glioblastoma or other solid tumors who were having surgery. The goal was to measure cell counts and viability to help scientists design better treatments for brain cancer and other solid tumors in t…

This study looked at whether whole genome sequencing (reading all of a tumor's DNA) could help find extra treatment options for people with recurrent glioblastoma, a serious brain cancer. 164 patients who needed a second surgery had their tumor DNA analyzed. The goal was to see i…

This study looked at whether an expensive PET scan called 18F-FDOPA helps doctors choose the right treatment for people with glioblastoma, a serious brain cancer. About 110 patients whose cases were discussed by a team of brain tumor experts were included. The main goal was to se…

This study looked back at medical records of 41 patients who had surgery for aggressive brain tumors (high-grade gliomas). Some surgeries used fluorescent dyes that make tumor tissue glow, helping surgeons tell it apart from healthy brain. The goal was to see if using these dyes …

This study looked at whether a combination of two drugs (LY3214996 and abemaciclib) can reach brain tumors in people with recurrent glioblastoma, a type of aggressive brain cancer. About 42 participants took the drugs before surgery to remove their tumor, and researchers measured…

This study looked at 244 people with a newly diagnosed brain cancer called glioblastoma. Researchers wanted to see if changes in platelet levels during early treatment could predict who might develop dangerously low platelets later. The goal was to create a simple monitoring plan…

This study looked at whether special brain scans (PET and CT perfusion) can predict how well the drug bevacizumab works in people with a returning brain tumor called glioblastoma. Fourteen patients were scanned before treatment to see if the images could tell who would respond to…

This small pilot study tested whether a type of PET/CT scan (FDG PET/CT) can detect very early changes in glioblastoma (a serious brain cancer) after starting chemotherapy. Seven patients were scanned shortly after beginning therapy to see if changes in tumor sugar use could pred…

This study looked at whether a special MRI technique can identify the most aggressive parts of a glioblastoma brain tumor. Researchers took tissue samples from different areas of the tumor during surgery and tested them for cancer stem cells. The goal was to see if MRI markers ma…