GLIOBLASTOMA

This phase 2 trial tested the drug pemigatinib in people with recurrent glioblastoma or other brain tumors that have specific changes in FGFR1-3 genes. Participants took a daily tablet for two weeks followed by one week off. The study aimed to see if the drug could shrink tumors,…

This early-phase trial tested a single dose of the cancer drug temsirolimus, given directly into the brain's blood supply, for people with recurrent high-grade glioma (a fast-growing brain tumor). Only 5 participants were enrolled, and the study was terminated early. The main goa…

This phase 3 trial tested two types of radiation therapy for glioblastoma, a fast-growing brain tumor. One group received standard 3D radiation, while the other got a more precise intensity-modulated radiation guided by MRI scans. Both groups also took the chemotherapy drug temoz…

This Phase 3 trial aimed to test the drug VAL-083 in people with recurrent glioblastoma, an aggressive brain cancer that had stopped responding to standard treatments. The study planned to enroll up to 180 participants, but was terminated early after only 2 patients were enrolled…

This early-stage trial tested a new drug called TAS2940 in 29 people with advanced solid tumors (like lung, breast, or brain cancer) that had specific genetic changes (EGFR or HER2). The goal was to find a safe dose and see if the drug could shrink tumors. The study was stopped e…

This early-phase trial tested the drug RMC-5552 in 7 adults with glioblastoma that had returned after standard treatment. The drug aims to block a protein that helps cancer cells grow. The study was terminated early, so results are limited.

This study tested a new drug called zotiraciclib (TG02) combined with the standard chemotherapy temozolomide in adults with recurrent brain tumors (anaplastic astrocytoma or glioblastoma). The goal was to find safe doses and see if the combination worked better than temozolomide …

This study looked at whether giving chemotherapy and radiation before surgery could help control glioblastoma, a fast-growing brain tumor. Only 2 people enrolled before the study was stopped. The goal was to see if this approach was safe and could delay tumor regrowth.

This study tested a new approach for glioblastoma, an aggressive brain cancer. Doctors injected a light-sensitive drug into the tumor and then activated it with a special laser. The goal was to see if it was safe and could help control the cancer. The trial was stopped early afte…

This early-phase trial tested the drug navtemadlin (AMG 232) in 32 adults with glioblastoma, an aggressive brain cancer. The study aimed to find the safest dose and see how much drug reaches the tumor. It was stopped early, but the goal was to control tumor growth, not cure the d…

This study tested whether a special MRI using ferumoxytol (an iron-based contrast agent) can accurately tell the difference between true tumor growth and treatment-related inflammation (pseudoprogression) in people with glioblastoma. About 52 patients were planned to receive stan…

This study aimed to see if a high-CBD hemp product could reduce anxiety and improve quality of life in people newly diagnosed with glioblastoma, a serious brain tumor. The trial planned to compare the CBD product to a placebo over 8 weeks, but it was stopped early after only 2 pe…

This study tested a drug called solriamfetol to see if it could safely help people with brain tumors (gliomas) feel more awake, think clearer, and have a better quality of life. Only 2 people enrolled before the study was stopped early. The main goal was to check for serious side…

This early-phase trial tested whether posaconazole, a drug used for fungal infections, can reach brain tumors in high enough amounts to stop cancer cells from dividing. Seven adults with glioblastoma took the drug before surgery, and researchers measured drug levels in their spin…

This early-phase study tested whether ketoconazole, a drug used for fungal infections, can enter glioblastoma brain tumors in high enough amounts to stop cancer cells from dividing. Only one adult with a high-grade glioma was enrolled before the study was terminated. The goal was…

This study looked at a molecule called microRNA-10b in brain tumor samples from 94 adults with gliomas. The goal was to see if higher levels of this molecule could help predict how long patients live or how their tumor behaves. Researchers also tested whether blocking this molecu…

This early-phase trial aimed to measure how much of the drug infigratinib reaches brain tumor tissue in people with recurrent high-grade glioma (a type of brain cancer). Only 7 participants were enrolled before the study was terminated. The main goal was to check drug levels in t…