GLIOBLASTOMA

This study tests a vaccine called SurVaxM, given alongside standard chemotherapy, for people with a newly diagnosed aggressive brain cancer (glioblastoma). The vaccine is designed to train the body's immune system to recognize and attack cancer cells. The main goal is to see if a…

This early study tested a personalized DNA vaccine in 9 people with a severe type of brain cancer called glioblastoma. The vaccine was made specifically for each patient based on their tumor's unique features. The main goals were to see if the vaccine was safe, possible to create…

This trial tests a personalized vaccine made from unique proteins in a patient's tumor. The goal is to train the immune system to recognize and attack cancer cells. It is open to people with solid tumors that have spread or are locally advanced. The study will check if the vaccin…

This study planned to test a two-part experimental treatment for newly diagnosed glioblastoma, a fast-growing brain cancer. The treatment combined a modified virus (Toca 511) designed to enter tumor cells and an extended-release antifungal drug (Toca FC) that the virus helps turn…

This trial compares two types of higher-dose radiation (IMRT or proton beam) plus the drug temozolomide against standard radiation plus temozolomide for people with newly diagnosed glioblastoma, an aggressive brain cancer. About 600 participants are being studied to see if the hi…

This early-phase trial is testing the immunotherapy drug nivolumab in children and young adults whose high-grade glioma has come back or is getting worse. Participants receive the drug before and after surgery to remove as much of the tumor as possible. The main goals are to chec…

This phase 4 study tests whether adding a special radiation tile (GammaTile) during surgery, followed by standard chemotherapy and radiation, is safe and feasible for people with newly diagnosed glioblastoma. About 61 adults will receive the tile at the time of tumor removal, the…

This phase II trial tests whether adding the immunotherapy drug nivolumab to re-irradiation and bevacizumab can improve outcomes for patients with recurrent glioblastoma, a type of aggressive brain cancer. The study enrolls 39 adults whose tumors have returned after standard trea…

This study tests an experimental drug called ST101 in people with advanced solid tumors, including glioblastoma, melanoma, breast, and prostate cancers that have spread or cannot be removed by surgery. The trial has two parts: first, finding a safe dose, and second, seeing if the…

This phase 1 trial tests a radioactive drug called Lutathera in people with glioblastoma, an aggressive brain cancer. The study includes two groups: newly diagnosed patients receiving Lutathera with standard radiation and chemotherapy, and patients with recurrent glioblastoma rec…

This phase 2 trial tests whether two targeted drugs, dabrafenib and trametinib, can improve outcomes for children and young adults with a specific type of high-grade glioma (BRAF V600-mutant) after they receive radiation therapy. The study enrolls 58 participants aged 25 or young…

This early-stage trial tests a therapy made from a patient's own immune cells, engineered to target a protein called B7-H3 found on glioblastoma cells. The cells are delivered directly into the brain via a small device. The study aims to find a safe dose and check for any signs t…

This study tests the drug abemaciclib in people whose glioblastoma has returned after prior treatment. The trial has two parts: one group takes the drug before surgery to measure how much reaches the tumor, and another group takes it to see if it can delay cancer growth. The goal…

This phase 3 trial tests whether giving the chemotherapy drug temozolomide earlier and for a longer time can help adults with glioblastoma live longer. About 486 participants will receive either the standard treatment or an intensified version that starts chemo within two weeks o…

This study tests a combination of an experimental drug (paxalisib), a diabetes drug (metformin), and a high-fat, low-carbohydrate ketogenic diet in people with glioblastoma, an aggressive brain cancer. The goal is to see if this approach is safe and can slow tumor growth. The tri…

This study planned to test a new treatment combining CYNK-001 (natural killer cells from donated cord blood) with interleukin-2 in adults whose glioblastoma had returned and could be surgically removed. The goal was to see if this combination was safe and could extend the time be…

This study tests whether adding weekly MRI scans during radiation treatment can help doctors better target high-grade gliomas, a type of aggressive brain tumor. About 20 adults with newly diagnosed tumors will receive standard radiation plus extra imaging to see if it improves tr…

This study tests a new treatment for people whose glioblastoma (a severe brain cancer) has come back. Doctors inject special immune cells (dendritic cells) and two immunotherapy drugs (ipilimumab and nivolumab) directly into the tumor during surgery, followed by more doses into t…

This study tests whether adding the immunotherapy drug pembrolizumab to standard treatment (temozolomide chemotherapy and Tumor Treating Fields) can help people with newly diagnosed glioblastoma live longer without their cancer growing. About 40 adults with this aggressive brain …

This study tests whether adding a second chemotherapy drug, lomustine, to the standard treatment (temozolomide plus radiation) helps people with a specific type of glioblastoma live longer. The trial includes 265 adults with newly diagnosed tumors that have a methylated MGMT gene…

This early-phase trial tests the drug niraparib in up to 42 people with two types of brain tumors: newly-diagnosed glioblastoma (a fast-growing cancer) and recurrent IDH-mutant glioma (a slower-growing type). The study first checks if the drug reaches the tumor and shows biologic…

This early-phase trial tests adding mycophenolate mofetil, a drug usually used to prevent organ rejection, to standard chemotherapy and radiation for glioblastoma. The goal is to find a safe dose and see if the combination can make tumor cells more sensitive to treatment. About 6…

This early-phase study tests whether adding the drug ibrutinib to standard radiation and chemotherapy is safe for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 36 adults with specific tumor types (MGMT methylated or unmethylated) will receive differ…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 52 adults with this diagnosis will receive the combination therapy. The main goals are…

This early-stage study tests a new surgery for people with a returning brain tumor called glioblastoma. Doctors remove the tumor and then place a piece of tissue from the patient's belly into the empty space. The goal is to see if this is safe and can help deliver treatments past…

This trial tests whether removing a wider margin of brain tissue around a glioblastoma tumor (supramarginal resection) improves survival compared to standard surgery. It involves 90 patients with suspected glioblastoma who are considered good candidates for the more extensive sur…

This early-phase trial tests a personalized vaccine (NeoVax) made from each patient's unique tumor mutations, combined with radiation and the immunotherapy drug pembrolizumab (Keytruda), in people with newly diagnosed glioblastoma. The main goals are to see if the vaccine can be …

This phase 2 trial tests the drug azeliragon, taken as a capsule, together with radiation therapy for people with a specific type of glioblastoma (a fast-growing brain cancer). The study includes 30 participants whose tumors lack a certain DNA marker (MGMT unmethylated). The goal…

This study tests whether a ketogenic diet (high fat, low carb) combined with the diabetes drug metformin is safe and tolerable for people with glioblastoma, an aggressive brain cancer. The idea is to lower blood sugar, which tumors use to grow. The 18 participants prepare their o…

This clinical trial tests a new drug called vebreltinib (PLB1001) in people with a recurrent form of glioblastoma that has a specific genetic marker (ZM fusion gene). The study compares the drug to standard chemotherapy to see if it helps people live longer. About 84 participants…

This early-stage trial tests whether specially engineered immune cells are safe and feasible for people with a recurring type of brain cancer called glioblastoma. The cells are designed to recognize and attack two specific proteins found on the cancer cells. The study involves 67…

This early-stage trial is testing an oral drug called silevertinib (BDTX-1535) in about 200 adults with advanced non-small cell lung cancer or glioblastoma that have certain EGFR mutations. The study has two parts: first finding a safe dose, then checking if the drug shrinks tumo…

This early-phase trial tests whether adding high-dose vitamin C and an iron drug (ferumoxytol) to standard radiation and chemotherapy can help control glioblastoma, an aggressive brain tumor. Seventeen adults with newly diagnosed glioblastoma will receive the combination. The mai…

This early-phase trial tests whether a personalized vaccine (made from each patient's tumor mutations) combined with standard care and a device that delivers low-intensity electric fields (Tumor Treating Fields) is safe and feasible for people with newly diagnosed glioblastoma. T…

This pilot study tests whether an energy-restricted ketogenic diet (ERKD) can help control glioblastoma, an aggressive brain cancer. Sixteen adults with newly diagnosed glioblastoma will follow the diet while receiving standard radiation and chemotherapy. The goal is to see if th…

This early-phase study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in teens and young adults with a type of brain tumor called glioma that has an IDH mutation. The goal is to find the safest dose and see how well the combination works for both newly diagn…

This study tests a combination of two drugs, L19TNF and lomustine, in 90 adults whose glioblastoma has returned or worsened. The goal is to find the safest and most effective dose to control the tumor and extend survival. Participants must have confirmed glioblastoma and be in ad…

This early-phase trial tests whether adding two experimental DNA vaccines (INO-5401 and INO-9012) and an immunotherapy drug (cemiplimab) to standard radiation and chemotherapy is safe and helps people with newly-diagnosed glioblastoma, a fast-growing brain cancer. About 52 adults…

This study tests an experimental immunotherapy called IGV-001 for people newly diagnosed with glioblastoma, an aggressive brain cancer. The treatment uses a patient's own tumor cells to create a personalized vaccine aimed at helping the immune system fight the cancer. The trial c…

This early-phase trial tests a new treatment for adults with aggressive brain cancers (glioblastoma, ependymoma, or medulloblastoma) that have spread to the lining of the brain and spinal cord. The treatment uses the patient's own immune cells, modified in a lab to recognize and …

This study tests whether adding veliparib to the standard chemotherapy drug temozolomide helps people with a newly diagnosed, aggressive brain cancer called glioblastoma. The trial includes 447 patients whose tumors have a specific genetic change (MGMT promoter hypermethylation).…

This study tests whether adding a drug called varlilumab to standard treatment and a personalized dendritic cell vaccine can help people with newly diagnosed glioblastoma live longer. About 43 participants will receive radiation, chemotherapy, and the vaccine, with some also gett…

This study tests whether giving a higher, targeted dose of radiation to the most aggressive parts of a glioblastoma brain tumor—adjusted over the course of treatment—can help patients live longer. About 30 adults with newly diagnosed glioblastoma will receive this personalized ra…

This early-phase trial tests whether adding the drug AZD1390 to standard radiation therapy can help people with a fast-growing brain tumor called glioblastoma (grade 4 glioma). The study includes both newly diagnosed and recurrent patients. First, researchers measure how much dru…

This early-phase trial is testing whether giving two immune-boosting drugs (nivolumab and ipilimumab) before surgery can help fight recurrent glioblastoma, a fast-growing brain cancer. About 63 adults whose tumor has returned after standard treatment will receive the drugs or a p…

This study tests whether adding the experimental drug BPM31510 (with vitamin K1) to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma live longer without their cancer growing. About 50 adults with this aggressive brain tumor will receive the co…

This early-stage study tests whether adding an experimental drug called OKN-007 to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 27 adults who have had surgery for their tumor will receive the combinat…

This study tested the drug trametinib in 4 people with advanced cancers that have GNAQ or GNA11 gene mutations. Trametinib blocks certain proteins that help these cancers grow. The goal was to see if the drug could shrink tumors or stop them from getting worse.

This study follows 165 children who previously took the drugs dabrafenib and/or trametinib for certain brain tumors. The goal is to see how safe these drugs are over the long term and how they affect growth, like height and weight. Participants continue their treatment and are mo…

This study tests whether adding an experimental drug called indoximod to standard chemotherapy and radiation can help children aged 3 to 21 with certain brain cancers. The drug aims to boost the body's immune system to fight tumors more effectively. The trial includes children wi…

This study tests a special type of radiation therapy that targets brain tumors while sparing the scalp to reduce side effects like wound infections. It involves 100 adults with newly diagnosed grade II to IV gliomas. The goal is to see if this approach is safer and still effectiv…

This early-phase trial tests a new drug called selinexor alongside standard radiation and chemotherapy for people with newly diagnosed glioblastoma, a fast-growing brain cancer. The main goal is to find the highest safe dose of selinexor that can be given with these treatments. A…

This early-phase study tests a combination of two immunotherapy drugs (domvanalimab and zimberelimab) in people whose glioblastoma has come back after initial treatment. The goal is to check if the drugs are safe and to see how they affect the tumor and immune system. About 46 pa…

This study tested a new drug called veliparib, given with radiation and chemotherapy, for children and young adults with a fast-growing brain tumor (high-grade glioma). The goal was to see if adding veliparib helps keep the cancer from coming back longer than standard treatment. …

This program gives certain glioblastoma patients access to SurVaxM, a vaccine-like treatment that may help slow tumor growth and extend survival. It is for Roswell Park patients who have no other treatment options or who finished a SurVaxM study and might benefit from continued t…

This trial tests an implantable ultrasound device that temporarily opens the blood-brain barrier, allowing chemotherapy to reach brain tumors. It includes 57 adults with recurrent glioblastoma who have already tried 1-2 treatments. The goal is to find a safe dose and see if this …

This early-stage study tests a genetically engineered virus (rQNestin34.5v.2) that is injected directly into recurrent brain tumors to see if it is safe and what dose works best. About 62 adults with certain types of brain cancer that have come back or worsened are taking part. T…

This early-stage study tests an oral drug called gallium maltolate in 26 people whose glioblastoma (a severe brain cancer) has returned after prior treatment. The main goal is to find a safe dose and see if it can slow tumor growth. Participants take the drug by mouth and are mon…

This study tests a combination of a drug (niraparib) and a device that delivers low-intensity electric fields (Tumor-Treating Fields) in 30 adults whose glioblastoma has returned after standard treatment. The goal is to see if this approach can control the tumor—shrinking it or k…

This study tests whether Tofacitinib, a drug used for arthritis, can slow tumor growth in people with recurrent glioblastoma (a type of brain cancer). About 17 adults whose cancer returned after standard treatment will take Tofacitinib pills twice daily. The goal is to see if it …

This early-phase trial tests a new immune cell therapy for people with recurrent or treatment-resistant malignant glioma, a type of brain cancer. The treatment uses the patient's own T cells, modified in the lab to recognize and attack cancer cells. The main goal is to find the s…

This phase 3 trial tests whether giving a dose of radiation directly to the tumor site during surgery (intraoperative radiotherapy) can help people with a newly diagnosed aggressive brain cancer called glioblastoma live longer without their cancer growing. The study involves 314 …

This study tests whether adding anlotinib hydrochloride to the standard Stupp regimen helps people with newly diagnosed glioblastoma live longer without their cancer growing. About 150 adults aged 18-75 are participating. The main goal is to see if the combination delays disease …

This study tests if the immunotherapy drug nivolumab can stop or slow the growth of certain brain tumors (gliomas) that have IDH mutations. Researchers are especially interested in tumors with many genetic changes (hypermutator phenotype). The trial involves 62 adults who receive…

This study tests whether adding the drug daratumumab to standard chemotherapy and radiation can help people with a newly diagnosed aggressive brain cancer called glioblastoma. About 16 participants will receive the combination treatment. The goal is to see if the new approach imp…

This study compares a short course of high-dose radiation to the standard longer course for people with glioblastoma, an aggressive brain cancer. The goal is to see if the shorter treatment works just as well at keeping patients alive while possibly causing fewer side effects. Ab…

This study tests a drug called olaparib in people with advanced cancers (like brain tumors, bile duct cancer, or other solid tumors) that have a specific gene change called IDH1 or IDH2 mutation. The drug works by blocking an enzyme that cancer cells need to grow. About 89 partic…

This early study tests a new imaging technique called qOBM that may help brain surgeons see tumor edges more clearly during surgery. About 24 adults with certain brain tumors (glioblastoma, astrocytoma, or oligodendroglioma) will have the device used during their planned tumor re…

This study tests an online mind-body program designed for people with brain tumors (glioma) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life for both. Researchers are enrolling 74 couples to see if the program is pract…

This study collects blood and bone marrow samples from 40 adults with newly diagnosed glioblastoma to track changes in immune cells over time. Researchers aim to understand how the immune system responds to the tumor and standard treatments. The goal is to gather foundational dat…

This study looks at whether advanced MRI scans can predict how well Optune therapy works in people with newly diagnosed glioblastoma, a type of brain cancer. Researchers will compare standard and advanced MRI in 60 participants to see which better forecasts survival at six months…

This study collects multiple samples from different parts of a glioblastoma tumor during surgery. Researchers will analyze the samples to learn how genetic changes vary within a single tumor. The goal is to improve future diagnosis and treatment of brain tumors. The study involve…

This study looks at how doctors, patients with glioblastoma (a serious brain cancer), and their caregivers talk about the disease, scan results, and treatment choices. Researchers will use surveys and tests to understand these conversations. The goal is to find ways to improve co…

This study tests a new way to monitor glioblastoma, a serious brain cancer. Instead of routine scans, patients report symptoms through an app, which may trigger an MRI sooner. The goal is to see if this approach is practical and acceptable for patients and doctors.

This study looks at whether simple blood tests can help doctors understand how glioblastoma, a serious brain cancer, changes over time. About 100 newly diagnosed patients will give blood samples before and after standard radiation and chemotherapy. The goal is to see if DNA from …

This early-phase trial studies how two oral drugs, defactinib and VS-6766, enter glioblastoma tumors and the surrounding brain tissue. Fourteen adults with new or recurrent glioblastoma who need surgery will take a single dose of one drug before their tumor is removed. The main g…

This study is observing 1,000 adults with recurrent malignant gliomas (aggressive brain tumors) to see how they respond to chemotherapy and targeted therapy. Researchers will track survival and tumor progression over time. The goal is to gather real-world data to help doctors cho…

This study explores whether an Apple Watch can track changes in walking, heart rate, breathing, and sleep in people with glioblastoma. The goal is to see if these measurements can help predict symptoms or complications before they happen. About 25 adults with newly diagnosed or r…

This study tests a new ultrasound system (SonoClear®) that uses a special gel to mimic brain tissue, aiming to give surgeons clearer images during brain tumor removal. Fifteen adults with glioma (a type of brain tumor) are participating. The main goal is to see if the new system …