Radical brain surgery for glioblastoma: could a wider cut save lives?
NCT ID NCT04243005
First seen Jan 09, 2026 · Last updated Jun 22, 2026 · Updated 24 times
Summary
This trial tests whether removing a wider margin of brain tissue around a glioblastoma tumor (supramarginal resection) improves survival compared to standard surgery. It involves 90 patients with suspected glioblastoma who are considered good candidates for the more extensive surgery. The goal is to see if this aggressive approach, guided by MRI, can extend life without causing unacceptable harm.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Erasmus MC
Rotterdam, Netherlands
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Haaglanden MC
The Hague, Netherlands
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Haukeland University Hospital
Bergen, Norway
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Helsinki University Hospital
Helsinki, Finland
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Karolinska University Hospital
Stockholm, Sweden
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Kuopio University Hospital
Kuopio, Finland
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Medical University of Vienna
Vienna, Austria
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Odense University Hospital
Odense, Denmark
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Oslo University Hospital, Rikshospitalet
Oslo, Norway
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Oulu University Hospital
Oulu, Finland
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Sahlgrenska University Hospital,
Gothenburg, Sweden
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St Olavs Hospital
Trondheim, Norway
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Tampere University Hospital
Tampere, Finland
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Turku University Hospital
Turku, Finland
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Ullevål University Hospital
Oslo, Norway
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University Hospital of Umeå
Umeå, Sweden
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Uppsala University Hospital
Uppsala, Sweden
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Supramarginal resection (surgery that removes a margin of at least 10 mm beyond the visible tumor)
What this could lead to
If it works, this could show that removing more tissue around the tumor helps people with glioblastoma live longer.
What could go wrong
This is a small, early-stage trial with only 90 patients. Removing more brain tissue may cause neurological problems, and the benefit is not yet proven.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.