Radical brain surgery for glioblastoma: could a wider cut save lives?

NCT ID NCT04243005

Ongoing Disease control Sponsor: St. Olavs Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether removing a wider margin of brain tissue around a glioblastoma tumor (supramarginal resection) improves survival compared to standard surgery. It involves 90 patients with suspected glioblastoma who are considered good candidates for the more extensive surgery. The goal is to see if this aggressive approach, guided by MRI, can extend life without causing unacceptable harm.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Supramarginal resection (surgery that removes a margin of at least 10 mm beyond the visible tumor)
What this could lead to: If it works, this could show that removing more tissue around the tumor helps people with glioblastoma live longer.
What could go wrong: This is a small, early-stage trial with only 90 patients. Removing more brain tissue may cause neurological problems, and the benefit is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA

Contacts and locations

Locations

Erasmus MC

Rotterdam, Netherlands
Haaglanden MC

The Hague, Netherlands
Haukeland University Hospital

Bergen, Norway
Helsinki University Hospital

Helsinki, Finland
Karolinska University Hospital

Stockholm, Sweden
Kuopio University Hospital

Kuopio, Finland
Medical University of Vienna

Vienna, Austria
Odense University Hospital

Odense, Denmark
Oslo University Hospital, Rikshospitalet

Oslo, Norway
Oulu University Hospital

Oulu, Finland
Sahlgrenska University Hospital,

Gothenburg, Sweden
St Olavs Hospital

Trondheim, Norway
Tampere University Hospital

Tampere, Finland
Turku University Hospital

Turku, Finland
Ullevål University Hospital

Oslo, Norway
University Hospital of Umeå

Umeå, Sweden
Uppsala University Hospital

Uppsala, Sweden

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