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New MRI dye could replace gadolinium for brain scans

NCT ID NCT06322342

First seen Jan 11, 2026 · Last updated Jun 18, 2026 · Updated 21 times

Summary

This study tested a new MRI contrast agent called RVP-001 in 18 adults with brain lesions from conditions like tumors or multiple sclerosis. The goal was to see if it is safe and can spot lesions as well as current gadolinium-based dyes, but without using gadolinium. Participants received one dose of RVP-001 and had their scans compared to earlier gadolinium-enhanced MRIs.

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Contacts and locations

Locations

  • Brigham & Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • University of Missouri

    Columbia, Missouri, 65212, United States

  • Yale New Haven Hospital

    New Haven, Connecticut, 06510, United States

Conditions

The condition(s) this trial relates to.

acoustic neuroma benign neoplasm of brain brain cancer brain neoplasm central nervous system cancer central nervous system neoplasm glioblastoma glioma meningioma metastatic malignant neoplasm in the brain multiple sclerosis neoplasm Neurilemmoma neurofibroma Neuroinflammatory Diseases neuronitis primary brain neoplasm primary central nervous system lymphoma schwannoma von Hippel-Lindau disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.