BRAIN CANCER

This study tests a new way to treat aggressive brain cancers that have come back after standard therapy. It combines a targeted drug called cetuximab, given directly into the brain's blood vessels, with a second round of radiation. The goal is to see if this approach can safely s…

This study tests a new drug called LMP744 in 40 adults whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or slow their growth.

This early-phase study tests a new approach for people with recurrent high-grade astrocytoma, a serious brain cancer. Participants receive a virus-based gene therapy injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the safest…

This study tests whether adding an experimental drug called silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. The trial is for patients whose tumors have certain genetic…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants will take part in virtual coaching sessions over 6 months, learning problem-solving and relaxation techniques. The …

This study is developing an AI method to track the movement of tumors and nearby organs during radiation therapy without using physical markers. Researchers will use data from 300 patients receiving radiation for various cancers or heart arrhythmias to train and test the system. …

This study involves 20 adults undergoing awake brain surgery for tumors in the hand movement area. Researchers will test different electrical stimulation settings to see which ones help or hinder hand movement. The goal is to improve how surgeons monitor hand strength during surg…

This study looks at whether a special PET scan using an investigational agent called 18F-Fluciclovine can find leftover tumor in people who had brain metastasis surgery and are scheduled for radiation. About 20 adults will get an optional PET scan before radiation. The goal is to…

This study looks at a new technology called SmartMatch that tests small pieces of brain or spinal cord tumor tissue against different drugs to find the best treatment. It involves 80 people aged 15 and older with recurrent CNS tumors who are already scheduled for surgery. The mai…

This study is testing whether a special PET scan using 18F-Fluciclovine can help doctors see how brain tumors respond to a precise type of radiation called stereotactic radiosurgery (SRS). About 46 adults with brain metastases (tumors that spread from other cancers) will get the …

This study tests a special version of the cancer drug nivolumab that has a fluorescent dye attached, called nivo800. The dye makes the drug glow under a special camera, allowing surgeons to see where the drug goes in the brain during tumor removal. The goal is to learn how well t…

This study tests whether advanced MRI scans can better identify parts of a brain tumor (glioma) that are likely to grow back after standard treatment. Researchers will compare these scans with usual methods to design safer, more targeted radiation plans. About 135 adults with sus…

This study looks at how much of the drug T-DXd gets into brain tumors in people with HER2-positive brain cancer or glioblastoma. About 30 adults will receive the drug before surgery, and researchers will measure drug levels in the tumor during the operation. The goal is to unders…

This study tests a new type of MRI that may help doctors see the most active parts of a brain tumor. The goal is to use this information to aim radiation therapy more precisely. About 20 adults with glioblastoma will take part to see if this approach improves treatment response.

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study looks at whether a special imaging agent called 18F-fluciclovine can help doctors see if radiation therapy is working on large brain tumors that have spread from other cancers. About 20 adults with at least one untreated brain tumor larger than 2 cm will get PET/CT sca…