BRAIN CANCER

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at high risk of coming back after radiation alone. About 134 adults with brain tumors from cancers like melanoma, lung, breast, or …

This early-stage trial tests a personalized treatment for glioblastoma, an aggressive brain cancer. It uses a patient's own immune cells, modified to better recognize and attack the tumor, combined with chemotherapy. The study aims to check safety and see if the treatment can shr…

This study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…

This early-phase study tests a genetically engineered virus (rQNestin34.5v.2) that targets and kills brain tumor cells. About 62 adults with recurrent malignant glioma will receive the virus injected directly into the tumor, sometimes with a drug called cyclophosphamide to boost …

This study compares a new AI system, COSMO, against human pathologists to see which can more accurately diagnose brain, lung, and kidney cancers from tissue slides. About 30 pathologists will review up to 300 de-identified images, while the AI analyzes the same cases independentl…

This study was designed to create a robotic system that keeps the head still during whole brain radiation therapy for brain cancer patients. The goal was to improve treatment accuracy by measuring how often the head stays within a tiny target zone. However, the study was withdraw…

This early-phase study tests the drug pembrolizumab in 60 adults with recurrent glioblastoma, an aggressive brain cancer. The main goal is to measure immune cell changes in the tumor and check for side effects. This is not a cure; it aims to gather information on how the drug wor…

This study looks at how doctors share information about brain tumors, scan results, and treatment choices with patients and their caregivers. Researchers hope to learn what helps or hinders clear communication about prognosis and care goals. About 309 people with glioblastoma, th…

This study tests a new imaging tracer for PET scans to see if it can help take pictures of brain tumors. Seventeen adults with malignant brain tumors or pituitary adenomas will receive a very small dose of the tracer. The goal is to learn how the tracer spreads and leaves the bod…