MENINGIOMA

This study is testing whether the drug cabozantinib can help control the growth of recurrent or worsening meningioma, a type of brain tumor. It will involve about 24 adults whose tumors have come back or progressed after standard treatments like surgery or radiation. The main goa…

This program provides eligible patients with access to an investigational drug called ITM11 for treating meningioma, a type of brain tumor, before it is officially approved. A treating doctor must decide if the potential benefits for an individual patient outweigh the risks of us…

This study is testing whether a pill called abemaciclib can help control an aggressive type of brain tumor called grade 3 meningioma. The drug is already approved for other cancers but not for brain tumors. Researchers will compare the pill against a placebo in 72 adults who have…

This study is testing a drug called Lutathera in children and young adults (ages 4 to 39) with aggressive brain or spinal cord tumors that have come back or gotten worse after standard treatments. Lutathera is a targeted radiation therapy that seeks out and attaches to specific m…

This study is testing if a newer type of radiation, called proton therapy, is better than standard X-ray therapy at preserving patients' quality of life after brain tumor treatment. It will involve 156 adults with certain types of brain tumors that have a good long-term outlook. …

This study is testing a special type of MRI scan called 3D MRE to see if it can measure how stiff and 'sticky' a brain tumor is before surgery. Researchers will scan 300 patients with a common type of brain tumor called a meningioma and compare the scan results to what surgeons f…

This study is testing whether a special radioactive tracer can help surgeons better see and remove a type of brain tumor called a meningioma during surgery. The tracer is injected before surgery and a handheld probe is used to detect it, potentially helping the surgeon find all t…

This study is testing a special microscope called the CONVIVO system. It is used during brain tumor surgery to help surgeons see the difference between healthy brain tissue and tumor tissue in real time. The images from the device are compared to standard lab tests from small tis…

This study is testing whether a new type of combined PET/MRI scan can help doctors better see if certain brain tumors have come back after treatment. It will involve 200 adults who have had surgery for specific brain tumors, like meningioma. The main goal is to see if this new sc…

This study is testing a robotic system to help doctors perform delicate procedures on blood vessels in the brain, such as treating strokes or blocking blood flow to tumors. It will compare the robot's performance to standard manual techniques. The goal is to see if the robot can …

This study is testing if a shorter, lower dose of steroids (dexamethasone) after brain tumor surgery can reduce side effects like high blood sugar and poor wound healing, without increasing the risk of dangerous brain swelling. It will compare a 4-day steroid schedule to the stan…

This study is testing a home-based program called HOBSCOTCH-CA, designed to help brain cancer survivors manage memory and thinking problems that often follow their illness. Participants will work one-on-one with a coach over video calls to learn problem-solving and relaxation tec…

This study aims to create a large collection of blood samples from cancer patients and people at high risk for cancer. Researchers will use these samples to build a research library for future studies on 'liquid biopsies'—blood tests that can detect cancer DNA. The goal is to hel…

This study aims to develop better ways to predict whether meningioma brain tumors will return after treatment. Researchers will analyze tumor tissue and blood samples from 210 patients to identify molecular markers that indicate recurrence risk. The goal is to create a blood test…

This study aims to understand why some patients develop memory and thinking problems after radiation therapy for a common, slow-growing brain tumor called meningioma. Researchers will use advanced MRI brain scans and thinking tests on about 67 patients before and after treatment …

This study is exploring whether tiny particles in the blood, called extracellular vesicles, can act as a 'liquid biopsy' to monitor meningioma brain tumors. Researchers will track these particles in 60 patients before, during, and after radiation therapy to see if changes in the …

This early-phase study is testing whether a new radioactive tracer, called Zr-89 crefmirlimab berdoxam, can help doctors see immune cells inside brain tumors using a PET scan. The goal is to see if this non-invasive scan can accurately show where immune cells are active, which co…

This study aims to understand how often a protective fluid around the brain leaks after surgery to remove a brain tumor. Researchers will follow 200 adult patients to see who develops a leak, identify what factors make it more likely, and track how doctors manage it. The goal is …