MENINGIOMA

This program gives eligible patients with meningioma early access to the investigational drug ITM-11 before it is officially approved. A doctor will decide if the possible benefits outweigh the risks for each patient. The program is only available in certain countries.

This study tests a drug called Lutathera in children and young adults (ages 4 to 39) whose brain tumors have come back or are growing despite treatment. The drug delivers radiation directly to tumor cells that show up on a special PET scan. The goal is to find the safest dose and…

This study tests several experimental drugs in people with NF2-related schwannomatosis, a rare genetic condition that causes non-cancerous tumors on nerves. The goal is to see if these drugs can shrink tumors or stop them from growing. About 109 participants will receive one of t…

This study tests a new treatment called [212Pb]VMT-α-NET for people with advanced tumors that have a specific marker (SSTR2). The treatment delivers targeted radiation to kill cancer cells while sparing healthy tissue. About 300 adults with neuroendocrine tumors or meningioma tha…

This study tests a new radiation technique called hypofractionated stereotactic radiosurgery for people with grade II or recurrent grade I meningiomas after surgery. The treatment delivers higher doses of radiation over fewer sessions to kill remaining tumor cells while reducing …

This study tests the drug cabozantinib in people whose meningioma (a type of brain tumor) has come back or is growing despite standard treatments. About 24 adults with any grade of meningioma will receive the drug to see if it can stop or slow tumor growth. The main goal is to me…

This study tests whether the drug abemaciclib can help people with a fast-growing type of brain tumor called grade 3 meningioma. Participants will receive either the drug or a placebo after standard radiation therapy. The goal is to see if the drug delays tumor growth and is safe…

This study tests a combination of two drugs—Lutathera (a targeted radiation therapy) and olaparib (a PARP inhibitor)—in children and teens aged 3 to 18 with solid tumors that have come back or not responded to standard treatment. The goal is to find the safest dose and see if the…

This study tests a special microscope called CONVIVO that lets surgeons see brain tissue up close during surgery. The goal is to help them tell the difference between normal brain and tumor tissue right away. About 30 adults with different types of brain tumors will take part. If…

This study is testing whether a special type of PET/MRI scan, called 68Ga-DOTATATE, can better detect brain tumors or tell if a tumor has come back after treatment. The study includes 200 adults with certain brain tumors, like meningioma. The goal is to see if this scan gives doc…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants will take part in virtual coaching sessions over 6 months, learning problem-solving and relaxation techniques. The …

This study looks at whether slowly lowering the dose of the steroid dexamethasone after brain tumor surgery can reduce side effects like high blood sugar and high blood pressure, while still preventing brain swelling. About 200 adults with certain brain tumors will be enrolled. T…

This study tests if a newer type of radiation (proton beam) can better protect brain function than standard X-ray radiation (photon) in adults with brain tumors. 156 participants will be randomly assigned to one of the two treatments. The goal is to see if proton therapy reduces …

This study looks at how removing a type of brain tumor called a meningioma affects a person's thinking and memory over a year. Researchers will test 50 adults before and after surgery to see if their cognitive skills change. The goal is to better understand the long-term effects …

This study looks at whether special MRI scans can predict which meningioma patients will have memory or thinking problems after brain radiation. About 67 adults with a slow-growing type of brain tumor will have advanced MRI scans and thinking tests before and up to two years afte…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study looks at epigenetic changes in meningioma, a common brain tumor, to find markers that might predict if the tumor will come back. Researchers will analyze tissue samples from 210 patients and also test blood samples for similar markers. The goal is to improve personaliz…

This study looks at how social, genetic, and environmental factors affect the health of people with meningioma, the most common type of brain tumor. Researchers will survey 3,000 adults to understand why some groups have worse outcomes. The goal is to find ways to improve care fo…

This study is testing whether a special type of MRI, called 3D magnetic resonance elastography (MRE), can measure the stiffness and stickiness of meningioma brain tumors before surgery. Researchers will compare the MRI results with what surgeons find during the operation and with…

This early-phase study tests a special PET scan that uses a radioactive tracer to find immune cells (CD8+ T-cells) inside brain tumors. About 20 adults with brain tumors scheduled for surgery will receive the tracer before their operation. The goal is to see if this imaging metho…

This study tests whether a special radioactive tracer, [Cu64]DOTATATE, can help surgeons find meningioma tumors during surgery using a handheld gamma probe. About 20 adults with suspected or confirmed meningioma will receive the tracer before surgery. The goal is to see if this m…

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks occur, what makes them more likely, and how doctors treat them. The goal is to find ways to reduce leaks and help patients heal better.

This study compares two common methods of closing the skin after brain tumor surgery: running stitches (absorbable) and individual stitches (non-absorbable). The goal is to see which method leads to fewer wound problems like infection or fluid leaks. About 382 adults having plann…

This study is testing whether tiny particles in the blood, called extracellular vesicles, can help doctors monitor meningioma brain tumors after radiation therapy. Researchers will collect blood samples from 60 patients before and after radiotherapy to see if changes in these par…

This early study tests whether a robot can help doctors perform delicate brain blood vessel procedures, such as taking images, blocking blood flow to tumors, or removing clots during a stroke. Ten people already scheduled for these standard treatments may have their procedure don…