GLIOMA

This study tests a new way to deliver a standard brain cancer drug (bevacizumab) using focused ultrasound and microbubbles in 10 people whose glioblastoma has returned. The goal is to see if this combination is safe and can help control tumor growth for longer. Participants must …

This study tests a drug called PLX038 in adults with brain or spinal cord tumors, especially those with changes in the MYC or MYCN genes. The goal is to see if the drug can shrink tumors or slow their growth. Participants receive the drug through an IV every 3 weeks and are follo…

This study tests a new way to treat aggressive brain cancers that have come back after standard therapy. It combines a targeted drug called cetuximab, given directly into the brain's blood vessels, with a second round of radiation. The goal is to see if this approach can safely s…

This study tests a combination of two drugs, tarlatamab and temozolomide, in teens and adults with high-grade brain tumors that have a specific marker called DLL3. The goal is to see if the combo is safe and can shrink or control the tumors. About 70 people will join, and the tre…

This study tests a special proton therapy technique that avoids the hippocampus, a brain area key for memory, in children with low-grade glioma. The goal is to see if this approach is possible and helps preserve memory and thinking skills over time. About 74 children with certain…

This trial tests whether a combination of two drugs, vemurafenib and cobimetinib, can shrink or control rare cancers that have a specific BRAF V600 mutation. The drugs are already approved for melanoma, and researchers want to see if they help people with other cancer types, like…

This study tests a two-step treatment for people with newly diagnosed high-grade gliomas, a fast-growing type of brain tumor. First, a laser is used to heat and destroy tumor tissue. Then, a short course of radiation is given to target remaining cancer cells. The goal is to contr…

This study tests whether adding an experimental pastille (APG-157) to standard bevacizumab can help people with recurrent high-grade glioma, a serious brain cancer. About 30 participants will take APG-157 daily by dissolving pastilles in their mouth, while continuing bevacizumab.…

This study tests a new drug called LMP744 in 40 adults whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or slow their growth.

This study tests whether a shorter, higher-dose radiation course guided by PET scans can improve survival for people with aggressive brain tumors (glioblastoma) who are not candidates for surgery. About 108 participants will be randomly assigned to either standard 3-week radiatio…

This study tests methimazole, a drug normally used for thyroid conditions, in people with progressive glioblastoma (a fast-growing brain cancer). The goal is to see if it can slow tumor growth and improve survival. About 19 participants will receive increasing doses to find the s…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard care. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to see if this combination is safe and can help control…

This early-stage study tests an experimental pill called GLIX1 in 30 adults whose high-grade glioma (a fast-growing brain tumor) has returned or worsened after standard treatments. The main goals are to find a safe dose and check for side effects. Participants take the pill daily…

This study tests a combination of two drugs—ATRA and retifanlimab—in people with a type of brain tumor (glioma) that has come back after standard treatment. The goal is to see if this combination can shrink tumors or slow their growth by boosting the body's immune response. About…

This early-phase study tests a genetically modified herpes virus (M032) injected directly into the brain tumor of children and adults with diffuse midline glioma, a rare and aggressive cancer. All participants must have completed standard radiation therapy 4 to 8 weeks before enr…

This study tests a drug called mirdametinib for people with certain brain or spinal cord tumors (like glioma). The goal is to see if the drug can shrink or control the tumors. About 26 adults will take part. The drug targets a specific genetic change (MAPK pathway) found in some …

This study tests whether adding focused ultrasound (NaviFUS) to the standard drug Avastin can help people with recurrent glioblastoma, an aggressive brain cancer. About 32 adults whose tumor has returned after prior treatment will be randomly assigned to receive Avastin alone or …

This early-stage study tests a new oral drug, PF-07799933, in people aged 16 and older with advanced solid tumors (like melanoma, lung, or colon cancer) that have a specific BRAF gene change and have stopped responding to standard treatments. The drug is given alone or combined w…

This early-phase study tests a personalized cell therapy for people with brain glioma. Doctors take immune cells from the patient's tumor, grow them in a lab, and give them back to the patient. The goal is to see if this treatment is safe and can shrink tumors. About 50 adults wh…

This early-phase study tests whether a radioactive drug called 177Lu-PSMA-617 is safe for people with a fast-growing type of brain cancer (IDH wild type glioma). About 20 adults whose tumors express a protein called PSMA will receive the drug after standard treatments. The main g…

This early-phase study tests a new approach for people with recurrent high-grade astrocytoma, a serious brain cancer. Participants receive a virus-based gene therapy injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the safest…

This study tests whether adding an experimental drug called silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. The trial is for patients whose tumors have certain genetic…

This study tests a drug called safusidenib in adults with a specific type of brain tumor (glioma) that has an IDH1 mutation. The goal is to see if the drug can shrink tumors or slow their growth. The trial has three parts, involving people with different stages of the disease, an…

This early-stage trial tests a special helmet that uses focused ultrasound to temporarily open the blood-brain barrier in people with glioblastoma, a severe brain cancer. The goal is to see if this approach is safe and can help standard chemotherapy reach the tumor more effective…

This early-phase trial tests whether combining four drugs (dasatinib, quercetin, fisetin, and temozolomide) is safe and feasible for adults with glioma that has residual disease after prior treatment. The approach uses individual patient feedback from scans and markers to guide t…

This study tests whether a combination of three drugs—pembrolizumab, olaparib, and temozolomide—can shrink or slow the growth of gliomas that have returned or not responded to earlier treatment. About 57 adults with a specific type of glioma (IDH-mutated, grade II or III) will re…

This early study tests a wearable device called Optune that creates low-intensity electric fields to disrupt cancer cell division. It is for adults with gliomas in the brainstem, a hard-to-treat area. The main goal is to see if the treatment is safe and tolerable for 10 participa…

This early-phase trial tests an experimental oral drug, NST-628, in adults with advanced solid tumors that have specific genetic changes in the MAPK pathway and have stopped responding to standard treatments. The study aims to find a safe dose and check for early signs of tumor s…

This study tests a drug called entrectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change (ROS1 fusion). About 30 adults and children with these rare tumors will receive the drug. Researchers will measure if tumors shrink …

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This study follows 150 adults with a certain type of slow-growing brain tumor (grade 2 glioma with an IDH mutation) who are taking the drug vorasidenib after surgery. The main goal is to see how the treatment affects their quality of life, including symptoms like seizures. Resear…

This study tests whether the drug ONC201 can help people with a rare and aggressive brain tumor called H3 K27M-mutant glioma live longer. Participants must have completed standard radiation therapy. The trial is double-blind, meaning neither patients nor doctors know who gets the…

This early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recogn…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study tests a shorter, more intense radiation schedule for people whose glioblastoma (a severe brain cancer) has returned after standard treatment. About 28 adults will receive radiation 4 times a week for 1 to 3 weeks. The goal is to find the safest dose that controls the t…

This early-phase trial tests a personalized vaccine called Tamavaq NeoVaccine in 29 adults with newly diagnosed glioma, a type of brain cancer. The vaccine is custom-made using AI and quantum mechanics to target unique mutations in each patient's tumor. The main goal is to check …

This study tests whether a special MRI technique called magnetic resonance elastography (MRE) can measure how stiff brain tissue is. The goal is to tell the difference between tissue damaged by radiation and tumor that has come back in people with gliomas. About 80 adults who hav…

This study tests a special MRI that uses a natural substance (pyruvate) to see if it can better diagnose brain tumors called gliomas. Five adults with suspected or known gliomas will get this MRI before surgery. The goal is to see if the scan can accurately predict the tumor type…

This study is testing whether a special PET/CT scan can help doctors find tumors in people with certain diseases, including amino acid transport disorders, primary hyperparathyroidism, and glioma. Researchers will scan 500 adults and measure how well the scan spots cancer or othe…

This study is testing a new type of MRI that uses a special substance (hyperpolarized carbon) to take clearer pictures of brain tumors called gliomas. The goal is to see if it is safe and if it can help doctors find and diagnose these tumors better. About 140 adults with glioma w…

This study is testing whether a special PET-MRI scan using 18F-fluciclovine can help doctors tell the difference between actual tumor growth and harmless changes that happen after treatment in children with high-grade glioma. About 30 children aged 1 to 21 with this type of brain…

This study tests a special PET/MRI scan that targets IDH mutations, a key genetic marker in gliomas (brain tumors). The goal is to accurately diagnose tumor subtypes and guide treatment without needing a biopsy. Ten adults with suspected or known gliomas will receive the scan to …

This study tests a faster MRI technique called Magnetic Resonance Fingerprinting (MRF) to see if it can clearly tell the difference between a brain tumor coming back and brain damage from radiation therapy. About 90 people will join, including healthy volunteers, people with new …

This study is testing whether artificial intelligence (AI) can accurately predict important molecular changes in gliomas, a type of brain tumor, by analyzing digital pathology images. Researchers will compare the AI's predictions against standard laboratory test results from 2,00…

This study tests whether escitalopram, a common antidepressant, can improve thinking and memory problems in people with a type of brain cancer called glioma. About 20 newly diagnosed patients will take the drug for 17 weeks while researchers measure changes in cognition, mood, an…

This study tests a support program for people recently diagnosed with a malignant brain tumor. The program includes a guide and one-on-one coaching sessions to help with coping. Researchers want to see if the program is practical and helpful for patients. About 50 adults from Mas…

This study looks at how the cancer drug olutasidenib changes the way the body processes other medications. Researchers will give a mix of test drugs to 16 adults with IDH1-mutated cancers (like AML or certain brain tumors) and measure their levels in the blood before and after ol…

This study looks at how brain tumors (gliomas) may change over time and whether advanced MRI and PET scans can predict those changes. Researchers will compare imaging results with tumor tissue samples from 20 adults undergoing surgery. The goal is to improve how doctors use scans…

This study tests a special version of the cancer drug nivolumab that has a fluorescent dye attached, called nivo800. The dye makes the drug glow under a special camera, allowing surgeons to see where the drug goes in the brain during tumor removal. The goal is to learn how well t…

This study looks at whether measuring the stiffness and stickiness of brain tumors (gliomas) using a special MRI technique called magnetic resonance elastography (MRE) can help doctors better understand the tumor's behavior. About 100 adults with newly diagnosed gliomas will have…

This study watches 1650 people with different types of brain tumors to see if the new 2021 classification system helps doctors choose better treatments. Researchers will track how long patients live and how well their tumors respond to therapy. The goal is to create clearer treat…

This study is testing a small device called a microdialysis catheter that is placed in the brain during surgery to collect fluid samples. The goal is to see if it is safe and can gather useful information (biomarkers) about brain tumors like glioblastoma and metastatic cancer. Ab…

This study listens to patients with a slow-growing brain tumor (IDH-mutant grade 2 glioma) to understand how they feel during different treatments. Researchers will compare quality of life, symptoms, and anxiety in people receiving radiotherapy, the drug vorasidenib, or no active…

This study aims to improve how brain tumors (gliomas) are diagnosed and treated by using advanced genetic testing. Researchers will build a network of UK hospitals to quickly analyze each tumor's unique genetic makeup. The goal is to match patients with targeted therapies that wo…

This study tests whether a special ultrasound dye can help brain surgeons tell the difference between tumor tissue and normal brain during glioma surgery. The goal is to remove as much tumor as safely possible. About 100 adults with suspected or recurrent glioma will take part. T…

This study looks at whether early telehealth visits can help people with a fast-growing brain tumor (high-grade glioma) discuss and document their end-of-life wishes soon after diagnosis. About 50 patients and their families will take part. The goal is to see if these visits are …

This study tests whether a mobile app can help people with glioma (a type of brain tumor) receive treatment and monitoring at home instead of traveling to a specialist center. The goal is to see if this digital approach is practical and acceptable for patients, especially those w…

This study tests a special MRI technique to measure a chemical called 2HG in brain tumors (gliomas) without needing surgery. About 30 adults with suspected or confirmed gliomas will get an MRI before their planned biopsy or tumor removal. The MRI results will be compared with lab…

This study is testing a mobile app called Iskhaa that lets brain tumor patients do neurological exams at home. About 600 people aged 5 and older will use the app to record videos of tasks like walking or speaking. The goal is to see if the app's results match what doctors find du…

This early-phase study tests a special PET scan that uses a radioactive tracer to find immune cells (CD8+ T-cells) inside brain tumors. About 20 adults with brain tumors scheduled for surgery will receive the tracer before their operation. The goal is to see if this imaging metho…

This study looks at how attention and vision problems change over time in 40 adults with a brain tumor called parietal lobe glioma. Researchers will test patients before and after surgery to understand these issues better. The goal is to help doctors create personalized treatment…

This study compares a new MRI technique (aMRI) to standard PET scans for measuring brain tumor activity in 20 adults with glioma. The goal is to see if aMRI can provide similar information without using radiation. If successful, this could make metabolic imaging more accessible a…

This study is testing a new MRI technique called CEST to create detailed maps of acidity (pH) inside brain tumors like gliomas and metastases. Researchers will scan 800 patients to see if pH levels can help predict where tumors might return or how long patients survive. The goal …

This study tests whether advanced MRI scans can better identify parts of a brain tumor (glioma) that are likely to grow back after standard treatment. Researchers will compare these scans with usual methods to design safer, more targeted radiation plans. About 135 adults with sus…

This study is looking at why some people with brain tumors (gliomas) develop dangerous low blood cell counts from the chemotherapy drug temozolomide, while others don't. Researchers will study genes, gut bacteria, and other factors in 55 patients to find predictors. The goal is t…

This study looks at platelets (small blood cells) in brain and spinal cord tumors to see if they affect tumor growth and patient survival. Researchers will examine tumor samples from 50 adults undergoing surgery. No new treatment is given; the goal is to learn how platelets inter…

This early study tests a new device called the CIPHER System in 10 adults having surgery for a newly diagnosed brain tumor (glioma). The device is used during the operation to record brain signals from the tumor and surrounding areas. The main goal is to check if the device is sa…

This study analyzes tumor tissue from up to 12,000 cancer patients to identify gene mutations. The goal is to match each patient with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to improve future cancer …

This study is creating a large database of brain tumor patients (70,000 people) to help doctors better understand and treat these cancers. It collects medical images, lab results, and patient outcomes. The goal is to improve diagnosis, predict survival, and guide treatment decisi…

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks occur, what makes them more likely, and how doctors treat them. The goal is to find ways to reduce leaks and help patients heal better.

This study compares two common methods of closing the skin after brain tumor surgery: running stitches (absorbable) and individual stitches (non-absorbable). The goal is to see which method leads to fewer wound problems like infection or fluid leaks. About 382 adults having plann…

This study is testing whether a special PET-MRI scan using a tracer called 18F-Fluciclovine can better monitor low-grade gliomas (a type of brain tumor) in children and young adults. About 30 participants will get the scan before starting treatment, then again at 3 months and 1 y…

This early study tests a new graphene-based electrode for brain mapping during surgery to remove brain tumors. Ten adults with glioma will have the device used alongside standard monitoring to check its safety and how well it records brain signals. Some participants who are awake…

This study looks at why some childhood cancer survivors continue to have symptoms like fatigue, pain, and trouble sleeping. Researchers will ask 600 survivors aged 8-18 about their symptoms and collect stool samples to study gut bacteria. The goal is to find links between gut hea…

This study looks at whether follow-up care for people with rare tumors can be done just as well by a nurse remotely as by a doctor in person. About 88 adults recently diagnosed with a rare tumor will be randomly assigned to either in-person doctor visits or remote nurse check-ins…