Engineered immune cells injected directly into the brain show promise for childhood cancers
NCT ID NCT04185038
First seen Jan 10, 2026 · Last updated May 12, 2026 · Updated 16 times
Summary
This early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recognize and attack a protein called B7-H3 found on many tumor cells. The main goals are to see if the treatment is safe and possible to make, and to learn how the cells move through the brain and body.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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