MEDULLOBLASTOMA, CHILDHOOD

This early-phase study tests whether a personalized immune cell treatment is safe for children under 5 with certain brain tumors. The treatment uses the child's own immune cells, trained to attack unique markers from their tumor. Up to 12 children will receive the therapy after s…

This study tests whether metformin, a common diabetes medicine, can help children and teens recover memory and thinking skills after finishing brain tumor treatment. About 140 participants aged 7 to 22 will take metformin or a placebo for 16 weeks. Researchers will measure change…

This early-phase study tests whether adding a chemotherapy drug (topotecan) given into the spinal fluid, followed by maintenance chemo, is safe and feasible for children under 6 with high-risk embryonal brain tumors. The goal is to improve cancer control after standard high-dose …

This early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recogn…

This study tests whether children and teens who finished treatment for medulloblastoma can do exercise sessions at home via video calls. Fifteen participants will exercise three times a week for 12 weeks. The goal is to see if this approach is practical, safe, and helpful for imp…

This study tests a new approach for children and young adults whose medulloblastoma or ependymoma has come back. Doctors will analyze the tumor's genes and test drugs on it in real time to create a personalized treatment plan. The goal is to see if this can be done quickly enough…