Medulloblastoma, childhood

This early-phase study tests the safety of a new cell therapy called B7-H3 CAR T cells for children and young adults whose brain tumors have come back or are growing despite standard treatment. The therapy uses the patient's own immune cells, modified to target a protein (B7-H3) …

This study tests a thyroid hormone called liothyronine (L-T3) alone or with standard chemotherapy in children and young adults whose medulloblastoma has come back or worsened. The goal is to see if adding L-T3 can help control the cancer better. About 69 participants will take pa…

This early-phase study tests whether adding chemotherapy directly into the spinal fluid (intrathecal topotecan) followed by maintenance pills is feasible for children under 6 with high-risk embryonal brain tumors. About 15 children will receive this treatment after standard high-…

This early-stage trial tests whether personalized immune cells (T-cells) can safely treat young children with aggressive brain tumors. The T-cells are designed to attack unique markers found on each child's tumor. Up to 12 children under 5 with embryonal brain tumors or recurrent…

This early-phase study tests whether a new type of immunotherapy, called B7-H3 CAR T cells, can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG, DMG, or other recurrent central nervous system cancers. The…

Researchers at St. Jude Children's Research Hospital are testing a brain-training method called real-time fMRI neurofeedback for survivors of childhood medulloblastoma. Many survivors struggle with attention and working memory after tumor treatment. In this study, 40 participants…

This Phase 3 trial tests whether metformin, a widely used diabetes drug, can improve memory and thinking in children and teens who have finished treatment for a brain tumor. About 140 participants aged 7 to 21 will take metformin or a placebo for 16 weeks. Researchers will measur…

This study tests whether children and teens who finished treatment for medulloblastoma can do exercise sessions through video calls. Fifteen participants will take part in personalized workouts three times a week for 12 weeks. The goal is to see if this approach is practical, saf…

Medulloblastoma is a rare but serious childhood brain tumor. Standard treatments can harm the developing brain, and some tumors stop responding to therapy. This study tests whether CDK4/6 inhibitors, drugs already used for breast cancer, can slow or stop medulloblastoma cells gro…

This study is testing a new approach for children and young adults whose medulloblastoma or ependymoma has come back. Researchers will analyze each person's tumor using drug screening and genetic testing to create a personalized treatment plan. The goal is to find the most effect…