GLIOMA

This early-stage study tests a new drug, DS-1001b, in 47 adults with a specific type of brain tumor (glioma) that has a certain genetic change (IDH1 mutation) and has come back after standard treatments. The main goal is to check the drug's safety and how the body processes it. R…

This study tests whether pembrolizumab, an immunotherapy drug that helps the immune system fight cancer, can shrink or stop the growth of recurrent malignant glioma in 27 patients. The cancer must have returned after prior treatments like radiation and chemotherapy. The goal is t…

This early-stage trial tests a new drug, BI 764532, in adults with a type of brain tumor (glioma) that has a specific marker called DLL3. The drug is designed to help the body's immune cells attack the tumor. The main goal is to find the highest dose that is safe, and to see if i…

This early-phase trial tests whether adding the drug AZD1390 to standard radiation therapy can help people with a fast-growing brain cancer called glioblastoma (grade 4 glioma). It includes both newly diagnosed and recurrent patients. The study first checks how much drug reaches …

This early-stage study tests an oral drug called LY3410738 in people with advanced solid tumors that have IDH1 or IDH2 gene mutations, including bile duct cancer, cartilage cancer, and brain tumors. The main goals are to find the best dose and check safety. About 200 participants…

This study tests a new treatment for a fast-growing type of brain tumor called high-grade glioma. The treatment uses a specially designed virus that targets and attacks tumor cells. The study will include 40 adults aged 18-80 who have not yet received any other cancer treatment. …

This study tests a drug called rhIL-7-hyFc in people with high-grade glioma (a type of brain tumor) whose immune cell levels drop after standard radiation and chemotherapy. The goal is to see if the drug can safely increase lymphocyte counts, which help fight infections and may i…

This study tests whether the immunotherapy drug nivolumab can help control brain tumors called gliomas that have specific genetic changes (IDH mutations). About 62 adults with these tumors will receive nivolumab through an IV every few weeks. The main goal is to see if the drug c…

This early-phase study tests whether adding the experimental drug ruxolitinib to standard brain cancer treatment (radiation and temozolomide) is safe and tolerable for people with newly diagnosed high-grade gliomas or glioblastoma. About 60 participants will receive the combinati…

This early-phase study tests a genetically engineered virus (rQNestin34.5v.2) that targets and kills brain tumor cells. About 62 adults with recurrent malignant glioma will receive the virus injected directly into the tumor, sometimes with a drug called cyclophosphamide to boost …

This study tests whether adding the drug abemaciclib to standard chemotherapy (temozolomide) helps children and young adults with a newly diagnosed high-grade glioma live longer without the tumor growing. About 45 participants will receive either the combination or chemo alone af…

This study tests a drug called niraparib in people with two types of brain tumors: newly diagnosed glioblastoma and recurrent IDH-mutant glioma with ATRX loss. The goal is to see if the drug reaches the tumor and slows its growth. Up to 42 participants will receive niraparib befo…

This early-stage study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The cells are…

This early-stage trial tests a new treatment for people with a severe type of brain cancer (grade 4 glioma) that has come back or not responded to standard therapies. The treatment uses the patient's own immune cells, modified in a lab to target a protein called IL-13Rα2 found on…

This study tests a special tool called DESI-MS that helps surgeons tell cancerous from healthy brain tissue during surgery. About 285 adults having brain tumor removal will take part. The goal is to see if this tool can give fast, accurate results to guide the operation.

This study tests a new type of MRI that looks at sodium and other signals in the brain to get a clearer picture of tumors. It includes healthy volunteers and people with brain tumors (glioma) that are new or have returned. The goal is to improve how doctors detect, understand, an…

This study compares proton beam therapy to standard photon radiation (IMRT) in 120 people with IDH-mutant grade II or III gliomas. The goal is to see which method better preserves memory and thinking skills after treatment. Both techniques aim to deliver radiation precisely to th…

This study tests whether a non-invasive brain stimulation technique called nrTMS can help people recover movement faster after surgery for a type of brain tumor called glioma. About 43 patients who have weakness on one side after surgery will receive either real nrTMS or a sham (…

This study tests a training program for family members caring for someone with a high-grade glioma (a serious brain tumor). The training teaches practical caregiving skills to reduce stress and improve the caregiver's and patient's well-being. About 124 caregivers and patients ar…

This study tests whether a couple-based yoga program can improve quality of life for people with high-grade glioma undergoing radiation therapy and their partners. About 216 couples will participate in Hatha yoga sessions designed to reduce fatigue, distress, and sleep problems. …

This early-phase study aims to see if researchers can measure how much of the cancer drug abemaciclib reaches the brain tumor and surrounding fluid in people with aggressive gliomas. Participants take the drug for a few days before surgery, then a small tube collects fluid from t…

This study looks at whether it's possible for people with a new brain tumor (glioma) to wear a step counter like a Fitbit during radiation therapy. Researchers want to see if tracking physical activity can help improve symptoms and quality of life. About 50 participants will wear…

This study looks at whether a special imaging technique called DMI can help predict how well a new drug (BPM31510) works in people with glioblastoma, a type of brain cancer. About 10 participants will receive the drug along with standard treatment and undergo imaging scans. The g…

This study tests a new MRI technique that tracks how the brain uses a special form of sugar (deuterated glucose). It includes 80 healthy adults and people with a type of brain tumor called glioma. The goal is to see if this method can detect differences in brain metabolism, which…

This study follows 71 people with glioma (a type of brain tumor) to see how radiation therapy affects their thinking skills over time. Researchers use special brain scans to map which brain networks are most sensitive to radiation damage. The goal is to learn how to protect these…

This study tests whether analyzing the genes in a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers (solid tumors, lymphoma, or myeloma) had their tumors genetically screened. Those with specific genetic c…

This study tests a new way to take pictures of high-grade glioma brain tumors using two special PET scans. The scans measure how little oxygen the tumor has and how fast its cells are growing. This information may help doctors understand why some tumors resist treatment. The stud…

This study looks at people with a type of brain cancer called glioma that has a specific gene change (IDH mutation). Researchers use special MRI scans to measure a substance called 2-HG in the brain over time, which may show when the tumor becomes more aggressive. The goal is to …