GLIOMA

This study is testing if the drug pembrolizumab can help control or shrink recurrent malignant brain tumors (gliomas) that have a specific high-mutation genetic pattern. The drug works by activating the body's own immune system to fight the cancer cells. The study is for adults w…

This early-stage study is testing a drug called niraparib for two types of aggressive brain cancer. It first checks if the drug reaches the tumor effectively after a short pre-surgery dose. If it does, participants can continue taking the drug, sometimes with radiation, to try to…

This study is testing a new treatment for a fast-growing type of brain cancer called high-grade glioma. Doctors are injecting a specially engineered virus directly into the tumor to try to kill the cancer cells and stimulate the body's immune system. The main goal is to see if th…

This study is testing a new drug called BI 764532 for adults with an aggressive type of brain cancer (glioma) that has stopped responding to standard treatments. The drug works by linking the patient's own immune cells to the cancer cells to help the body fight the tumor. The mai…

This early-stage study is testing whether adding an experimental drug called ruxolitinib to standard brain cancer treatment (radiation and chemotherapy) is safe for patients. Researchers want to find the highest dose of ruxolitinib that patients can tolerate without severe side e…

This is an early-stage study to test the safety and initial effects of an experimental drug called DS-1001b in adults with recurrent glioma, a type of brain tumor. The drug specifically targets tumors that have a particular genetic change called an IDH1-R132 mutation. The main go…

This study is testing whether adding a drug called abemaciclib to standard chemotherapy (temozolomide) works better for controlling aggressive brain tumors in children and young adults who have just finished radiation. About 45 participants will be randomly assigned to receive ei…

This early-stage study is testing a new treatment for children and young adults whose brain or spinal cord tumors have come back or haven't responded to standard therapies. Doctors collect the patient's own immune cells, modify them in a lab to recognize and attack cancer cells, …

This study is testing whether the immunotherapy drug nivolumab can help control the growth of certain brain tumors (gliomas) that have specific genetic changes. It is enrolling 62 adults whose tumors have either a very high number of mutations or a normal number. The main goal is…

This study is testing whether a non-invasive brain stimulation technique can help patients recover arm and hand movement after surgery for a type of brain tumor called a glioma. Researchers will compare a real stimulation treatment to a fake (sham) treatment in 43 patients who ha…

This study is testing whether a new drug called rhIL-7-hyFc can safely increase the number of infection-fighting white blood cells in people with aggressive brain tumors. The trial involves 42 patients who have already received standard radiation and chemotherapy. The main goal i…

This study aims to see if a new type of brain scan (called DMI) can predict how well a treatment works for glioblastoma, an aggressive brain cancer. It will test the scan in patients who are also receiving an experimental drug (BPM31510) added to standard care. The main goal is t…

This large national trial is testing whether choosing cancer drugs based on the specific genetic changes found in a patient's tumor is more effective than standard approaches. It is for adults with advanced solid tumors, lymphoma, or multiple myeloma that have progressed after at…

This is a first-in-human safety study testing a genetically engineered virus, rQNestin34.5v.2, as a potential treatment for recurrent malignant brain tumors (gliomas). The virus is designed to infect and kill only cancer cells while sparing healthy brain tissue. The main goals ar…

This early-stage trial is testing the safety and initial effects of a new type of CAR-T cell therapy for adults with aggressive brain tumors (grade 4 glioma) that have returned or not responded to standard treatments. The therapy involves modifying a patient's own immune cells to…

This early-stage trial is testing a new drug called AZD1390 in combination with standard radiation therapy for adults with aggressive brain tumors (grade 4 glioma or glioblastoma). The study first checks if the drug successfully reaches the tumor tissue. Patients whose tumors sho…

This study is testing a new type of MRI scan designed to see brain tumors in more detail. It aims to help doctors better detect, understand, and potentially track how tumors respond to treatment. The study involves patients with glioma brain tumors who are scheduled for surgery o…

This study is testing how well a special type of PET scan can tell the difference between a brain tumor coming back and harmless changes caused by previous cancer treatments like radiation. Researchers will analyze scan data from 400 people with glioma who had the scan as part of…

This study is testing whether combining two types of medical scans (PET and MRI) with artificial intelligence (AI) can more accurately determine how aggressive a solid tumor is. It involves about 135 adults with prostate cancer or other solid tumors like liver or brain cancer. Th…

This study is testing a new technology called DESI-MS to see if it can help surgeons during brain tumor operations. The goal is to quickly tell the difference between healthy brain tissue and cancerous tissue right in the operating room. This could help surgeons remove tumors mor…

This study is testing a training program to help family members who care for loved ones with aggressive brain tumors. The program teaches practical caregiving skills with the goal of reducing distress for both the caregiver and the patient, and improving the patient's symptoms. R…

This study is testing whether a yoga program designed for couples can improve quality of life for people with a serious brain tumor (glioma) and their partners. Patients and their caregivers attend yoga sessions together during radiation treatment. The goal is to see if yoga help…

This study aims to understand how a specific type of brain tumor (glioma) changes and becomes more aggressive over time. Researchers will use special brain scans to track chemical levels in the tumors of about 42 adults who have this condition. The goal is to learn if these chemi…

This study aims to see if researchers can measure how much of an oral cancer drug (abemaciclib) gets into a person's aggressive brain tumor and the fluid surrounding it. Participants are adults aged 18-39 with a recurrent high-grade glioma. They take the drug for a few days befor…

This study is testing a new brain imaging method that uses a special form of sugar to see how glioma brain tumors use energy. Researchers will scan 80 participants—including healthy people and those with glioma—to develop better imaging techniques. The goal is to understand tumor…

This study is testing whether it's practical to track daily steps in people with newly diagnosed brain tumors (glioma) during their radiation therapy. Researchers want to see if patients will consistently wear either a basic pedometer or a Fitbit device for 6 weeks. The goal is t…

This is a small, early-stage study to test a new scanning method for aggressive brain tumors called high-grade gliomas. Researchers want to see if they can use two special PET scans at the same time to create a detailed map showing which parts of the tumor have low oxygen and whi…