GLIOMA

This study tested a special type of radiation (pulse reduced dose rate) given with the drug bevacizumab for people with recurrent high-grade glioma, an aggressive brain cancer. The goal was to see if this combination could help patients live longer and control the disease. The tr…

This study tested a new drug called VAL-083 in people with glioblastoma, an aggressive brain cancer, that had come back after standard treatments. The goal was to see if VAL-083 could help patients live longer. However, the trial was stopped early after only 2 people enrolled, so…

This study tested a drug called solriamfetol to see if it could help people with brain tumors (gliomas) feel more awake and improve their memory, mood, and quality of life. Only 2 people enrolled before the study was stopped early. The main goal was to check for side effects.

This early-stage study looked at whether ketoconazole, an antifungal drug, could block a protein called tGLI1 in brain tumors. The study included 15 people with either breast cancer that spread to the brain or a type of brain tumor called glioma. The goal was to see if the drug c…

This study aimed to see how much of the drug infigratinib gets into brain tumors in people with recurrent high-grade glioma (a type of brain cancer). Only 7 participants were enrolled before the study was stopped. The main goal was to measure drug levels in tumor tissue, blood, a…

This early-stage trial enrolled 5 people with recurrent high-grade glioma (a type of aggressive brain tumor). Participants received a single dose of the drug temsirolimus, given directly into the brain's blood vessels or through a vein, on the same day as planned tumor removal su…