GLIOMA

This trial tests whether two drugs already approved for certain skin and lung cancers can help people with rare cancers that have a specific gene change called BRAF V600. About 30 adults and children with various rare cancers will receive dabrafenib and trametinib. The goal is to…

This study tests a new approach called pharmacoscopy, which uses a lab test on a patient's tumor sample to find which drugs might work best for them. It involves 40 adults with brain tumors like glioblastoma that have not responded to standard treatments. The goal is to see if th…

This early-phase trial tests whether sitagliptin, a common diabetes pill, can help treat a severe brain cancer (grade 4 glioma) that has returned after standard therapy. About 45 adults will receive sitagliptin alongside the standard drug bevacizumab. The main goals are to find t…

This early study tests whether a device that stimulates the brain, combined with physical therapy, can help the brain rewire itself before surgery. The goal is to move important functions away from the tumor area so surgeons can remove more of the tumor without causing lasting ha…

This study looks at tiny chemical changes on RNA molecules in blood and urine to see if they can help diagnose gliomas, a type of brain tumor. Researchers will test samples from 228 adults scheduled for brain surgery and compare them to healthy controls. The goal is to find a sim…

This early-phase study tests whether a dye called SBK2-ICG can help surgeons see the exact edges of brain tumors during surgery. About 12 adults with suspected or confirmed malignant brain tumors will receive the dye before their standard surgery. The goal is to find the best dos…

This early study tests if a tiny device can safely collect fluid from the brain during planned surgery for glioma or epilepsy. Six participants will have the microperfusion catheter placed temporarily during their operation. The goal is to see if the device works and is safe, not…

This small study at Yale tests whether fMRI neurofeedback can help people with brain tumors (gliomas) shift language activity away from the tumor area before surgery. Only 4 participants will be enrolled to see if the approach is feasible and acceptable. The goal is to preserve l…

This study tests a special microscope attachment (GLOW400) that helps surgeons see glowing brain tumors during surgery. About 37 adults with suspected high-grade gliomas will take part. Surgeons will rate how well the tool shows the tumor and brain structures. The goal is to conf…

This study tests whether a smartphone app can help monitor symptoms and quality of life in 80 adults with IDH-mutated glioma (a type of brain tumor) who are starting a new cancer treatment. Participants will use the Resilience PRO app to answer weekly questionnaires about their s…

This study is testing whether a new imaging technique can help surgeons see tumor cells in people with glioma, a type of brain cancer. Researchers will observe 80 adults during surgery to see if multispectral imaging improves tumor visualization. The goal is to gather information…

This study tests a new, ultra-fast lab test (called UR-ddPCR) that can detect leftover IDH1-mutant tumor cells during brain surgery. If the test finds any remaining cancer cells, the surgeon can remove more tissue right away. The goal is to see if this approach helps people with …

This study tests whether a short course of physical therapy, with or without brain stimulation, before surgery can help the brain reorganize motor function in adults with high-grade glioma near the movement area. About 63 participants will be randomly assigned to standard care, p…

This study looks at whether a special PET scan (18F-AGX) can detect early changes in brain tumors (low-grade IDH-mutant gliomas) during treatment with the drug Vorasidenib. Ten adults with recurrent or residual tumors will receive the drug and undergo both MRI and PET scans over …