GLIOMA

This study aims to see if special training before brain tumor surgery can help the brain adapt and protect movement function. Researchers will test two types of 'prehabilitation'—physical therapy alone and physical therapy combined with non-invasive brain stimulation—in adults wi…

This UK trial is testing whether two already-approved cancer drugs, dabrafenib and trametinib, can effectively treat rare cancers or common cancers with a rare genetic change called a BRAF V600 mutation. The study will enroll about 30 adults and children with various cancers that…

This early-stage trial is testing a new drug called LMP744 in adults whose aggressive brain cancer (glioblastoma) has returned after standard treatment. The main goal is to see if the drug can shrink or stabilize tumors and is safe for patients. Participants will receive the drug…

This pilot study is testing a new approach to help surgeons remove more of a brain tumor while protecting critical functions like movement and speech. Researchers will implant a small device that gently stimulates the brain to temporarily weaken a function, while physical therapy…

This study is testing a personalized approach to find treatments for brain tumors that have stopped responding to standard therapies. Doctors will test tumor cells from surgery in a lab to see which drugs might work best for each patient. The goal is to see if this 'drug-matching…

This is a first-in-human study to find a safe dose of an experimental oral drug called GLIX1 for adults with aggressive brain tumors (high-grade glioma or glioblastoma) that have returned or worsened after standard treatments. The main goal is to check the drug's safety and side …

This early-stage study is testing the safety of a genetically modified herpes virus (M032) designed to fight a rare and aggressive type of brain tumor called diffuse midline glioma. The virus is injected directly into the tumor during surgery in up to 20 children and adults who h…

This study is testing whether adding a new oral drug called silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of aggressive brain cancer (glioblastoma) live longer without their cancer getting worse. It will involve about 162 newly diagnosed p…

This early-stage study is testing the safety of a new imaging dye called SBK2-ICG. It is given to adults with malignant brain tumors about an hour before their scheduled surgery. The goal is to see if the dye, which glows under special light, can help surgeons more clearly see th…

This study is testing a special camera that attaches to a surgical microscope. It takes pictures during brain tumor surgery to see if it helps surgeons better visualize the tumor tissue. The study will enroll 80 adults with a suspected aggressive brain tumor (glioma) who are alre…

This study is testing a new, very fast DNA test that can detect leftover brain tumor cells while a patient is still in surgery. The goal is to give surgeons immediate feedback, so if cancer cells are found, they can remove more tissue right away. Researchers will then track patie…

This study aims to develop a new way to diagnose and monitor brain tumors called gliomas. Researchers will look for specific chemical markers in patients' blood, urine, and tumor tissue to see if they can create a more accurate test. The goal is to improve diagnosis and track the…

This study is testing a new digital camera accessory for a surgical microscope. It aims to help neurosurgeons see suspected aggressive brain tumors more clearly during surgery. The study will observe 37 patients in Europe to see if the new tool provides better image quality and v…

This study aims to find the best way to close the skin after brain tumor surgery. Researchers will compare two common stitching techniques in 382 adult patients to see which leads to fewer wound problems like infections or leaks. The goal is to improve healing so patients can rec…

This early study is testing a new version of a cancer drug (nivolumab) that has been made to glow. The goal is to see if this glowing drug can safely help surgeons better see and map out aggressive brain tumors during surgery. The study will involve 38 adults with high-grade glio…

This study is testing whether a new type of PET scan (called 18F-AGX PET) can detect early signs of how well the drug Vorasidenib is working in adults with a specific, recurring type of slow-growing brain tumor. The goal is to see if changes on this special scan happen before cha…

This is the first human study of a new, flexible device called the CIPHER System. It will be tested on 10 adults having standard surgery to remove a newly diagnosed brain tumor (glioma). The main goal is to check if the device is safe to use during surgery and to see how well its…

This study is testing a mobile app called Resilience PRO to see if it can help patients with a specific type of brain tumor (IDH-mutant glioma) better manage their symptoms and quality of life. The app will send weekly surveys to 80 patients to track their symptoms, fatigue, and …