GLIOMA

This study tested whether adding two immune-boosting drugs (retifanlimab and epacadostat) to standard radiation and bevacizumab could help people with recurrent glioblastoma, a fast-growing brain tumor. The trial enrolled 51 adults whose cancer had returned. The goal was to see i…

This early-phase trial tested an oral drug called AG-881 in 95 adults with advanced gliomas (a type of brain tumor) that have IDH1 or IDH2 gene mutations. The main goals were to check safety, find the best dose, and see if the drug slows tumor growth. Participants had tumors that…

This small pilot study tested whether adding a focused ultrasound device (NaviFUS) to standard chemotherapy (bevacizumab) could help control recurrent glioblastoma, an aggressive brain cancer. Six adults whose cancer returned after prior treatment took part. The main goals were t…

This study tested a combination of two drugs, Fluvastatin and Celebrex, in 20 children and young adults with certain types of brain tumors (gliomas) that had come back or not responded to treatment. The main goal was to find the safest dose of Fluvastatin when given with a fixed …

This study tested two experimental drugs, AG-120 and AG-881, in 49 adults with a recurrent low-grade glioma that has a specific IDH1 mutation. Participants took the drugs before surgery to see if they could lower a substance called 2-HG in the tumor. The main goal was to measure …

This study tested whether a focused ultrasound device (ExAblate) can safely and repeatedly open the blood-brain barrier in 20 adults with high-grade glioma (a type of brain cancer). The goal was to help standard chemotherapy reach the tumor more effectively. Researchers measured …

This early-phase study tested an oral drug called AG-120 in 174 people with advanced solid tumors (including bile duct cancer, bone cancer, and brain tumors) that have a specific IDH1 gene mutation. The goal was to find the safest dose and see how the drug works in the body. Part…

This study tested a drug called VAL-083 combined with standard radiation for people newly diagnosed with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to find a safe dose and see if the combination helps control th…

This early-phase study tested a new treatment for children and young adults with brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein called EGFR fou…

This study tested a new MRI contrast agent called RVP-001 in 18 adults with brain lesions from conditions like tumors or multiple sclerosis. The goal was to see if it is safe and effective at highlighting these lesions without using gadolinium, a metal that can build up in the bo…

This study tested whether a special PET scan called 18F-FDOPA can help doctors make better treatment decisions for people with brain tumors (gliomas or metastases) when standard MRI results are unclear. 85 patients whose MRI scans left doctors unsure about the next step received …

This study looked at whether a type of PET scan using a special tracer called [18F]FET can accurately tell the difference between a returning brain tumor (glioma) and harmless changes caused by previous treatment. Researchers analyzed scans from 253 patients of all ages who had a…

This study looked at whether a combination of two drugs, LY3214996 and abemaciclib, can reach brain tumors in people with recurrent glioblastoma. About 42 participants took the drugs before surgery to remove their tumor. Researchers measured drug levels in the tumor tissue and sp…

This study looked at whether video visits (telehealth) are as satisfying as in-person clinic visits for people with brain tumors (gliomas) who are taking oral chemotherapy. Thirty patients alternated between telehealth and in-person checkups, and researchers measured their satisf…

This study looked at whether it is possible to give a drug called AB-218 to people with a specific type of slow-growing brain tumor (IDH1-mutated low grade glioma) before their surgery. Fourteen adults who had not received prior radiation or chemotherapy took part. The main goals…

This study looked at how quality of life and thinking skills change in people with a slow-growing brain tumor (low-grade glioma) who are receiving chemotherapy. Researchers followed 26 patients for a year, checking their well-being and mental function. The goal was to better unde…

This study looked at memory complaints in 426 people, including those with brain tumors, breast cancer, and healthy volunteers. Researchers focused on 'prospective memory'—remembering to do things in the future, like taking medication. They found that cancer patients reported mor…

This study tested whether combining PET/MRI scans with machine learning can more accurately determine how aggressive solid tumors like prostate cancer are. Researchers scanned 50 adults with prostate, liver, kidney, or brain tumors and compared the AI results to standard tissue a…

This study looked at 44 people with a type of brain tumor called glioma. Researchers used a special MRI scan to see if the swollen brain tissue around the tumor still worked. They then took small samples of that tissue during surgery to check for signs of healthy brain cells. The…

This small pilot study tested a new type of MRI called Field Cycling Imaging (FCI) in 9 people who had surgery for low grade glioma. The goal was to see if FCI can tell apart different subtypes of these brain tumors without needing a biopsy. Participants had one extra scan to hel…

This study tested whether analyzing the genetic makeup of a child's tumor could help doctors choose better treatments. 186 children with cancers that had come back or were not responding to standard therapy took part. The goal was to see if this approach was practical and safe, n…