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Targeted pill shows promise for rare cancers with specific gene flaw

NCT ID NCT02073994

First seen Mar 11, 2026 · Last updated Apr 30, 2026 · Updated 6 times

Summary

This early-phase study tested an oral drug called AG-120 in 174 people with advanced solid tumors (including bile duct cancer, cartilage cancer, and brain tumors) that have a specific IDH1 gene mutation. The goal was to find a safe dose and see how the drug works in the body. Participants took the drug until their disease worsened or side effects became too severe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Study site

    Scottsdale, Arizona, 85258, United States

  • Study site

    Los Angeles, California, 90095, United States

  • Study site

    Aurora, Colorado, 80045, United States

  • Study site

    Miami, Florida, 33136, United States

  • Study site

    Baltimore, Maryland, 21218, United States

  • Study site

    Boston, Massachusetts, 02215, United States

  • Study site

    New York, New York, 10065, United States

  • Study site

    Nashville, Tennessee, 37203, United States

  • Study site

    Dallas, Texas, 75390, United States

  • Study site

    Houston, Texas, 77030, United States

  • Study site

    San Antonio, Texas, 78229, United States

  • Study site

    Villejuif, 94800, France

Conditions

Explore the condition pages connected to this study.