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Brain zap and therapy may let surgeons remove more tumor safely

NCT ID NCT04745156

Disease control Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests a new approach for people with slow-growing brain tumors located in areas that control movement. A small device placed on the skull delivers mild electrical stimulation while patients do physical therapy, aiming to retrain the brain so that critical functions move away from the tumor. The goal is to allow surgeons to remove more of the tumor without causing permanent weakness or speech problems. Only 3 adults will take part to check if the procedure is safe and feasible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 3 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18-65 years old 2. Ability to understand a written informed consent document, and the willingness to sign it 3. Radiographic evidence of likely low-grade glioma on MRI (i.e. non-enhancing) invading primary motor cortex in the non-dominant hemisphere. 4. Karnofsky performance status (KPS) ≥ 75 5. Normal or near normal motor strength (i.e., at least 3/5 in relevant areas) 6. Normal or near normal speech (Can consistently name at least 4/5 cards) 7. No medical contraindication to surgery 8. Free of other illness that may shorten life expectancy Exclusion Criteria: 1. Presence of other malignancy not in remission 2. Evidence of bi-hemispheric or widespread tumor involvement 3. Likely candidate to receive GTR on initial resection 4. Medically high-risk surgical candidate 5. History of recent scalp or systemic infection 6. Presence of other implants or foreign bodies in the head 7. Inability to receive an MRI for any reason 8. Inability to receive cortical stimulation for any reason 9. Coagulation disorders and/or use of anti-thrombotic therapies 10. Platelet count \< 50 11. Diathermy procedures 12. Electroconvulsive Therapy (ECT) 13. Transcranial Magnetic Stimulation (TMS) 14. Presence of implanted cardiac device (such as a pacemaker or defibrillator) 15. Pregnant women

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm glioma low grade glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain cancer Brain tumor GLIOMA Glioma intracranial Gliomas benign Motor cortex; lesion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.