Engineered immune cells injected directly into brain show promise for kids with deadly tumors

This early-phase study tests a new treatment for children and young adults with HER2-positive brain tumors that have come back or not responded to standard therapy. The treatment involves collecting the patient's own immune cells, engineering them to recognize and attack HER2 on tumor cells, and then delivering them directly into the brain through a small tube. The main goals are to see if this approach is safe and feasible, and to learn how the cells behave in the body.