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Triple-Drug attack shows promise for tough brain tumors

NCT ID NCT05188508

First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 33 times

Summary

This study tests whether a combination of three drugs—pembrolizumab, olaparib, and temozolomide—can shrink or slow the growth of gliomas that have returned or not responded to earlier treatment. About 57 adults with a specific type of glioma (IDH-mutated, grade II or III) will receive the drugs together. The goal is to see how well the combination works and how safe it is.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-••••

Locations

  • BAPTIST ALLIANCE - MCI (Data Collection Only)

    RECRUITING

    Miami, Florida, 33143, United States

    Contact Phone: •••-•••-••••

  • Hartford Healthcare Alliance (Data Collection Only)

    RECRUITING

    Hartford, Connecticut, 06102, United States

    Contact Phone: •••-•••-••••

  • Lehigh Valley Health Network (Data Collection Only)

    RECRUITING

    Allentown, Pennsylvania, 18103, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

    RECRUITING

    Basking Ridge, New Jersey, 07920, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    RECRUITING

    Montvale, New Jersey, 07645, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)

    RECRUITING

    New York, New York, 10065, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    RECRUITING

    Middletown, New Jersey, 07748, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Nassau (Limited Protocol Activities)

    RECRUITING

    Uniondale, New York, 11553, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Suffolk -Commack (Limited Protocol Activities)

    RECRUITING

    Commack, New York, 11725, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    RECRUITING

    Harrison, New York, 10604, United States

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.