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Brain cancer breakthrough? new CAR-NK cell trial targets glioblastoma

NCT ID NCT07480941

First seen Mar 28, 2026 · Last updated Jun 22, 2026 · Updated 14 times

Summary

This early-stage trial tests a new approach for people with recurrent glioblastoma, a fast-growing brain tumor. Doctors take immune cells called NK cells, engineer them to recognize and attack tumor cells, and deliver them directly into the brain. The study will check safety and find the best dose in 36 adults.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Peking University Shenzhen Hospital

    RECRUITING

    Shenzhen, Guangdong, 518036, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

CAR-NK cells (immune cells engineered to attack brain tumor cells)

What this could lead to

If it works, this could point toward a new treatment option for recurrent glioblastoma, a brain cancer with very few effective therapies.

What could go wrong

This is a very early Phase 1 trial with only 36 participants, so safety and effectiveness are not yet proven. The treatment involves brain surgery and chemotherapy, which carry serious risks.

Conditions

The condition(s) this trial relates to.

glioblastoma glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.