MALIGNANT GLIOMA

This is a first-in-human study testing a new type of cell therapy for adults with recurrent or progressive glioblastoma or other high-grade brain tumors. The therapy uses 'off-the-shelf' natural killer immune cells that are genetically engineered to recognize and attack two speci…

This early-stage trial is testing whether giving a single, precise, high-dose radiation treatment (radiosurgery) *before* surgery can help control aggressive brain tumors (high-grade gliomas) better and with fewer side effects. The study will find the safest and most effective do…

This is a first-in-human study testing a new cell therapy called CARv3-TEAM-E for glioblastoma, an aggressive brain cancer. Researchers will collect a patient's own immune cells, genetically modify them to target cancer, and reinfuse them to see if they can safely fight the tumor…

This early-stage study is testing the safety of a small, implanted ultrasound device in children with hard-to-treat brain tumors that have come back. The device is designed to temporarily open a natural protective barrier in the brain, which may allow more chemotherapy to reach t…

This study is testing whether adding a new oral drug called selinexor to standard radiation therapy is safe and effective for children and young adults with newly diagnosed, aggressive brain tumors (DIPG or high-grade glioma). The first part of the trial aims to find the safest d…

This study is testing a special fluorescent dye attached to an antibody (panitumumab-IRDye800) that sticks to brain tumor cells. During surgery, a special camera can see the glowing dye, which may help surgeons better tell tumor tissue apart from healthy brain tissue and find sma…

This small pilot study is testing whether combining a special low-carb diet with a supervised exercise program can help people with malignant glioma feel better. Fifteen participants will follow a 15-week program of twice-weekly workouts and a modified Atkins diet. The main goal …

This study is testing whether a special type of MRI scan and a blood test can help doctors better predict how an aggressive brain tumor (glioblastoma) might change or return after treatment. Researchers will enroll 15 adults with a new diagnosis to see if these tools can spot sig…

This study aims to develop better MRI methods to map electrical properties in the brain. It involves 120 participants, including healthy volunteers and people with a type of brain tumor called glioma. The goal is to improve how doctors can see and understand brain function and he…

This early study aims to understand how two oral drugs affect the chemical environment inside brain tumors. Researchers will study 18 adults with a type of brain cancer called glioma who are already scheduled for surgery. After removing part of the tumor, a tiny tube will be plac…

This study is testing whether taking more frequent MRI scans during radiation and chemotherapy treatment for aggressive brain tumors (high-grade gliomas) can help doctors see how the tumor is changing. By spotting changes earlier, doctors might be able to adjust the radiation tre…