MALIGNANT GLIOMA
Clinical trials for MALIGNANT GLIOMA explained in plain language.
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Brain cancer drug delivered directly into tumor shows promise in early trial
Disease control CompletedThis early-phase study tested a new drug called D2C7-IT in 81 adults with recurrent malignant glioma, a serious brain cancer. The drug was infused directly into the tumor over 72 hours using a special delivery method. The main goal was to find the safest dose and check for side e…
Matched conditions: MALIGNANT GLIOMA
Phase: PHASE1 • Sponsor: Darell Bigner • Aim: Disease control
Last updated May 26, 2026 06:51 UTC
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New combo therapy shows promise in tough brain cancer trial
Disease control CompletedThis study tested whether adding whole brain radiation and a drug called plerixafor to standard chemotherapy can help people with a fast-growing brain tumor called glioblastoma. The trial included 21 newly diagnosed patients. The goal was to see if this combination could slow tum…
Matched conditions: MALIGNANT GLIOMA
Phase: PHASE2 • Sponsor: Lawrence D Recht • Aim: Disease control
Last updated May 18, 2026 12:02 UTC
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New hope for kids with tough cancers: targeted drug shows promise in early trial
Disease control CompletedThis study tested a drug called samotolisib in 18 children and teens whose cancers (solid tumors, lymphoma, or related disorders) had spread, returned, or stopped responding to treatment. Only those with specific gene mutations (TSC or PI3K/MTOR) were eligible. The goal was to se…
Matched conditions: MALIGNANT GLIOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 18, 2026 12:02 UTC
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New PET scan technique may sharpen radiation targeting for brain cancer
Knowledge-focused CompletedThis study tested whether a special PET scan (18F-DOPA) can better detect brain tumors during radiation planning for people with newly diagnosed gliomas. About 91 participants received the scan before and during radiation therapy. The goal was to see if this imaging method helps …
Matched conditions: MALIGNANT GLIOMA
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 19, 2026 12:01 UTC
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Blood test may predict brain tumor treatment success
Knowledge-focused CompletedThis study examined 47 adults with newly diagnosed glioblastoma or gliosarcoma to see if changes in immune cells in the blood could predict how well they respond to a combination of immunotherapy drugs (ipilimumab and nivolumab) plus standard chemotherapy. Participants had alread…
Matched conditions: MALIGNANT GLIOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated May 18, 2026 12:01 UTC