MALIGNANT GLIOMA

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with advanced cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can help control the cancer. About 350 people with various cancer types, …

This early-phase trial tests whether specially engineered immune cells (T cells) can safely target and kill recurrent malignant glioma, an aggressive brain cancer. About 29 patients will receive these cells to find the best dose and check for side effects. The goal is to control …

This study tests whether taking two targeted pills (dabrafenib and trametinib) after radiation therapy can help children and young adults up to age 25 with a specific type of aggressive brain cancer (BRAF V600-mutant high-grade glioma). The drugs block proteins that fuel tumor gr…

This study tests a drug called pembrolizumab in children whose brain tumors have come back or not responded to treatment. The drug helps the body's immune system fight cancer cells. The goal is to find the safest dose and see if it can shrink tumors in children with several types…

This early-stage study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in adolescents and young adults with IDH1/2-mutant gliomas, a type of brain tumor. The goal is to find the safest dose and check for side effects. About 78 participants with newly diagnose…

This study tests whether adding the drug veliparib to standard radiation and chemotherapy can help children and young adults with a newly diagnosed aggressive brain tumor called high-grade glioma. Veliparib blocks a protein that helps cancer cells repair themselves, potentially m…

This study tests whether the immunotherapy drug nivolumab can help control brain tumors called gliomas that have specific genetic changes (IDH mutations). About 62 adults with these tumors will receive nivolumab through an IV every few weeks. The main goal is to see if the drug c…

This study looks at whether a wearable device called Optune is safe and practical for children with aggressive brain tumors. In one group, kids with recurrent high-grade glioma or ependymoma use the device alone. In another group, children with newly diagnosed DIPG use the device…

This study tests a new type of MRI that looks at sodium and other signals in the brain to get a clearer picture of tumors. It includes healthy volunteers and people with brain tumors (glioma) that are new or have returned. The goal is to improve how doctors detect, understand, an…

This study tests an online mind-body program for people with brain tumors (glioma or cancer spread to the brain) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life. About 74 couples will participate to see if the program…

This study looks at whether adding a special PET scan (18F-DOPA) to the standard MRI can help doctors better plan radiation treatment for people with certain brain tumors (malignant glioma). About 25 participants will have both scans, and researchers will compare the treatment ar…

This study screens children and young adults (ages 1–21) with advanced solid tumors, lymphomas, or related disorders that have come back or not responded to standard therapy. Researchers analyze the genetic makeup of each patient's tumor to find specific mutations that can be tar…

This study looks at people with a type of brain cancer called glioma that has a specific gene change (IDH mutation). Researchers use special MRI scans to measure a substance called 2-HG in the brain over time, which may show when the tumor becomes more aggressive. The goal is to …