Glow-in-the-Dark dye could help surgeons zap brain tumors
NCT ID NCT03510208
First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times
Summary
This study tests a special dye that makes brain tumor cells glow under a camera during surgery. The goal is to help surgeons see and remove more of the tumor while sparing healthy brain tissue. About 46 adults with malignant glioma or vestibular schwannoma will receive the dye before their planned surgery. The study checks for side effects and how well the dye highlights tumor tissue.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 46 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2018
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1\) One of the following: 1. Cohorts 1, 2, and 3: Participants with suspected or confirmed diagnosis of glioblastoma 2. Cohort 4: Participants with suspected or confirmed diagnosis of vestibular schwannoma 2.) Planned surgical removal of the tumor as part of standard of care. This may include participants postchemotherapy, post-radiation, and/or participants who have undergone diagnostic biopsy for their original diagnosis and are felt to be candidates for resection. 3\) Participant age ≥ 18 years. 4\) Participants or their designated advocates must be willing to and capable of providing informed consent and willing and able to comply with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures. Exclusion Criteria: 1. Received an investigational drug within 30 days prior to first dose of Panitumumab-IRDye800. 2. Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); significant liver disease as determined by PI; or unstable angina within 6 months prior to enrollment. 3. History of infusion reactions to monoclonal antibody therapies 4. Pregnant or breastfeeding. 5. Evidence of QTc prolongation on pretreatment ECG (greater than 440 ms in males or greater than 460 ms in females). 6. Any of the following lab values: 1. Platelet count \< 75,000/mm3 2. TSH ≥ 13 micro International Units/mL. 3. Magnesium, potassium, or calcium \< each respective upper limit of normal 4. Serum creatinine \> 1.5 times upper limit of normal 7. Participants receiving Class IA (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents. 8. Participants with a history or evidence of interstitial pneumonitis or pulmonary fibrosis. 9. Participants not deemed by PI to be appropriate candidates for optimal resection of tumor based on location, involvement of eloquent brain, satellite lesions, or other factors not specifically listed here.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Stanford University School of Medicine
RECRUITINGPalo Alto, California, 94304, United States
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Other studies related to the condition(s) this trial covers.
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