MALIGNANT BRAIN NEOPLASM

This early-phase study tests a new treatment for children whose brain tumors have returned or not responded to standard care. The treatment uses the child's own immune cells, which are modified in a lab to better recognize and attack tumor cells. These cells are given along with …

This study tests whether adding a special PET scan (18F-DOPA PET/CT) to standard imaging helps doctors better manage brain tumors. About 47 adults with brain tumors will get this extra scan. The goal is to see if the new scan changes treatment plans in a meaningful way for more t…

This study tests a special dye that attaches to brain tumor cells and makes them glow under a camera during surgery. The goal is to help surgeons see and remove more of the tumor while sparing healthy brain tissue. About 46 adults with malignant glioma or vestibular schwannoma wi…

This study tests two advanced MRI techniques to better tell apart brain tumors that have come back from tissue damage caused by radiation therapy. About 42 adults with brain metastases will be scanned before surgery or radiation. The goal is to help doctors choose the right treat…

This study tests whether the diabetes drug metformin, combined with a wearable activity tracker, can reduce memory and thinking problems caused by brain radiation. About 100 adults who have had or will have cranial radiation for a brain tumor will participate remotely using a web…

This study looks at whether slowly lowering the dose of the steroid dexamethasone after brain tumor surgery can reduce side effects like high blood sugar and high blood pressure, while still preventing brain swelling. About 200 adults with certain brain tumors will be enrolled. T…

This study explores whether specific breathing exercises can boost brain and mental health in people with multiple sclerosis or certain cancers, as well as their caregivers. Researchers will use brain scans to measure oxygen delivery and fluid flow in the brain. The goal is to un…

This early-phase study tests a special PET scan that uses a radioactive tracer to find immune cells (CD8+ T-cells) inside brain tumors. About 20 adults with brain tumors scheduled for surgery will receive the tracer before their operation. The goal is to see if this imaging metho…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to see how these vessels work, which could help decide if a patient's tumor is likely to respond to certain treatments.…

This study aims to learn more about cancer genes in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumors to see how common certain gene changes are. The goal is to improve cancer risk assessment and tailor screening for these popu…

This study follows 250 young adults (ages 18-39) recently diagnosed with cancer to see how their social relationships and physical activity change over time and affect their quality of life. Researchers will track hospitalizations, treatment details, exercise habits, and well-bei…

This study looks at whether a video and a special doctor's visit can help young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start planning their future medical care early. The goal is to see if these tools are helpful and easy to use. About 50 people…