RECURRENT GLIOBLASTOMA

This study is testing a combination of three drugs—pembrolizumab, olaparib, and temozolomide—to see if they can better control recurrent glioblastoma, an aggressive brain tumor that has grown back after initial treatment. The trial is for adults whose cancer has returned once or …

This is an early-stage trial testing a new drug called RMC-5552 in adults whose glioblastoma, a fast-growing brain cancer, has returned. The main goals are to find the safest and most effective dose and to see how well the body handles the drug. Researchers will also check if the…

This is a first-in-human study testing a new type of cell therapy for adults with recurrent or progressive glioblastoma or other high-grade brain tumors. The therapy uses 'off-the-shelf' natural killer immune cells that are genetically engineered to recognize and attack two speci…

This study aims to find the safest schedule for giving radiation treatment to people whose glioblastoma brain tumors have returned after previous radiation. Researchers will test three different treatment lengths (1, 2, or 3 weeks) in 28 adults with recurrent grade 4 brain tumors…

This study is testing a new drug called sacituzumab govitecan for adults whose aggressive brain cancer (glioblastoma) has returned after initial treatment. The drug is designed to target cancer cells that have high levels of a specific protein. Researchers will give the drug to a…

This study is testing if a drug called atezolizumab, given before surgery, can help control recurrent glioblastoma, a very aggressive brain cancer. It will enroll 80 adults whose cancer has returned after standard treatment and who have a specific tumor characteristic called low …

This is a first-in-human study testing a new cell therapy called CARv3-TEAM-E for glioblastoma, an aggressive brain cancer. Researchers will collect a patient's own immune cells, genetically modify them to target cancer, and reinfuse them to see if they can safely fight the tumor…

This early study is testing a new, non-invasive treatment for glioblastoma, a fast-growing brain cancer that has returned or worsened. The treatment combines a special drug with focused ultrasound waves, guided by an MRI machine, to try to kill cancer cells without surgery. The m…

This early-stage study is testing a new personalized treatment for adults with a specific type of recurrent brain cancer called glioblastoma. Doctors take a patient's own immune cells, genetically modify them in a lab to better target the cancer, and then infuse them back into th…

This study is testing a combination of two drugs, atezolizumab and cabozantinib, for adults with glioblastoma that has returned after initial treatment. The goal is to see if this combination is safe and can help control the cancer by boosting the immune system and blocking tumor…

This early-stage trial is testing a new treatment for aggressive brain cancers that have returned. Doctors are using stem cells to carry a specially engineered cold virus directly to the tumor. The goal is to see if the virus can safely infect and kill the cancer cells while spar…

This early-stage study is testing the safety of a new type of treatment called CAR-T cell therapy for adults with a specific type of recurrent brain cancer (glioblastoma). Doctors will give patients modified versions of their own immune cells, either after chemotherapy or before …

This study aims to find out if the cancer drug trastuzumab deruxtecan (T-DXd) can get into brain tumors when given through an IV. Researchers will measure how much of the drug reaches the tumor during surgery in 30 adults with certain HER2-positive brain cancers or recurrent glio…

This early-stage study is testing the safety and best dose of an experimental drug called CUE-102 in adults whose glioblastoma brain cancer has returned for the first time. CUE-102 is designed to activate the body's immune system to fight the tumor. The study will enroll about 18…

This study is testing a new way to treat glioblastoma, a very aggressive brain cancer that has come back after initial treatment. Doctors will place tiny radioactive seeds directly into the tumor to deliver radiation from the inside. The main goals are to see if this procedure is…

This is a first-in-human, early-stage trial testing the safety and initial effectiveness of a new type of CAR-T cell therapy called EPC-003 for adults with recurrent or treatment-resistant glioblastoma, a serious brain cancer. The therapy involves collecting and genetically modif…

This study is testing whether a new combination of two immunotherapy drugs (relatlimab and nivolumab) works better and is safer than the standard chemotherapy (lomustine) for glioblastoma that has returned after initial treatment. The trial will involve about 184 adults whose bra…

This early study is testing a new device called TheraSphere GBM that delivers targeted radiation directly to recurrent glioblastoma brain tumors. The research aims to see if this approach is safe and technically possible for patients whose cancer has returned after standard treat…

This early study is testing whether the drug troriluzole can help control recurrent glioblastoma, an aggressive brain cancer. About 27 adults whose cancer has returned will receive the drug either before and after standard tumor-removal surgery, or only after surgery, to see if i…

This study is testing the safety and effectiveness of a new drug called pumitamig, both alone and in combination with other cancer drugs, for adults whose aggressive brain cancer (glioblastoma) has returned after initial treatment. The goal is to see if these treatments can shrin…

This study is testing the safety and feasibility of a three-part treatment for adults whose aggressive brain cancer (glioblastoma) has returned. The treatment combines a wearable device that uses electric fields to disrupt cancer cells, a precise laser surgery to destroy the tumo…

This study aims to understand the biology of glioblastoma, a serious brain cancer, by analyzing MRI scans. Researchers will study 50 adults with this cancer who are scheduled for surgery. The goal is to find patterns in the scans that might predict which patients could benefit fr…

This study aims to learn more about glioblastoma, an aggressive brain cancer, by using two types of specialized PET scans and a powerful MRI machine. Researchers will scan up to 15 adults with new or returning glioblastoma who are already scheduled for surgery. The goal is to see…