RECURRENT GLIOBLASTOMA

This early-stage trial tests a new cell therapy called E-SYNC CAR T cells for people with a specific form of glioblastoma, an aggressive brain cancer. The treatment uses a patient's own immune cells, modified in a lab to better recognize and attack the tumor. About 20 adults will…

This early-phase trial tests a new treatment called EPC-003, a type of CAR-T cell therapy, in 14 people with glioblastoma that has come back or not responded to standard care. The therapy is given directly into the fluid around the brain through a small device. The main goal is t…

This early-phase trial tests a new treatment for recurrent glioblastoma, a fast-growing brain cancer. Researchers take a patient's own immune cells, modify them to recognize and attack the tumor, and give them back after chemotherapy or before surgery. The main goal is to check s…

This early-stage study tests a new drug called YSCH-01, alone or with another drug (atezolizumab), in 10 people whose glioblastoma (a severe brain cancer) has returned. The main goal is to check safety and see if the treatment helps patients live at least one year longer. Partici…

This study tests if combining three treatments—electric field therapy (TTFields), laser ablation surgery, and an immunotherapy drug (pembrolizumab)—is safe and doable for adults with recurrent glioblastoma, an aggressive brain cancer. About 20 participants will receive the combin…

This trial tests a new gene therapy called TGX-007 for people with a fast-growing brain cancer called glioblastoma. The therapy uses a harmless virus to deliver two special instructions into the tumor: one helps a common antiviral drug kill cancer cells, and the other wakes up th…

This study tests whether a device called TheraSphere GBM is safe for people whose glioblastoma brain tumor has come back. It delivers tiny radioactive beads directly to the tumor through blood vessels. The trial will enroll 36 adults and watch for serious side effects like brain …

This early-phase study tests the safety of an experimental drug called CUE-102 in 18 adults whose glioblastoma (a type of brain cancer) has returned after initial treatment. The drug is designed to help the immune system target cancer cells. The main goal is to find the safest do…

This study tests a new drug called LMP744 in 40 adults whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or slow their growth.

This study tests a combination of three drugs (pembrolizumab, olaparib, and temozolomide) in adults whose glioblastoma brain tumor has come back after prior treatment. The goal is to see if this mix can boost the immune system's attack on the tumor and slow or stop its growth. Ab…

This study tests a drug called sacituzumab govitecan in people whose glioblastoma (a type of brain cancer) has come back after standard treatment. The goal is to see if this drug helps patients live longer compared to an older chemotherapy. About 32 adults with high levels of a s…

This early study tests a new treatment for glioblastoma, an aggressive brain cancer that has come back after prior therapy. The approach combines an investigational drug (5-ALA) with focused ultrasound waves to target and damage tumor cells before surgery. Only 11 participants wi…

This study tests a new way to deliver radiation for recurrent glioblastoma, a serious brain cancer. Doctors place tiny devices that release alpha radiation directly into the tumor. The goal is to see if this is safe and possible for 10 adults whose tumors have come back and canno…

This study tests a new drug called pumitamig, alone or with other medicines, in 75 adults whose glioblastoma (a severe brain cancer) has come back after standard treatment. The goal is to see if these combinations can shrink tumors and are safe. Participants must have had prior r…

This early-phase trial tests whether combining two drugs, atezolizumab and cabozantinib, can safely shrink tumors in adults with glioblastoma that has returned after standard treatment. The study enrolls about 6 participants and focuses on tumor response and side effects. The goa…

This early-phase trial tests a new approach for people with recurrent high-grade glioma, a fast-growing brain cancer. Researchers use stem cells to carry a modified cold virus directly to the tumor via an artery, where the virus is designed to infect and kill cancer cells. The ma…

This trial tests a device called SonoCloud-9 that uses ultrasound to temporarily open the blood-brain barrier, allowing more chemotherapy (carboplatin) to reach brain tumors. About 560 adults with recurrent glioblastoma will either get this new combination or standard chemotherap…

This early-phase study tests a new treatment called CARv3-TEAM-E T cells for people with glioblastoma, a fast-growing brain cancer. The treatment uses the patient's own immune cells, modified in a lab to better recognize and attack the tumor. The main goal is to find the safest d…

This early-phase study tests a new treatment for adults with glioblastoma or high-grade glioma that has come back after standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to target two different markers on tumor cells at once, which may h…

This early-phase trial tests a new treatment for adults with glioblastoma or other high-grade gliomas that have come back after standard therapy. The treatment uses specially engineered immune cells (CAR-NK cells) that are designed to target two different markers on tumor cells a…

This study tests whether the immunotherapy drug atezolizumab can help people with recurrent glioblastoma, a type of brain cancer that has come back after initial treatment. Researchers will look at genetic markers in tumors to see who might benefit most. About 80 adults with recu…

This early-stage trial tests a new treatment called sonodynamic therapy for people with glioblastoma that has come back or is getting worse. The treatment combines a drug (5-ALA) that makes tumor cells sensitive to sound waves, with focused ultrasound waves that target and destro…

This study tests a shorter, more intense radiation schedule for people whose glioblastoma (a severe brain cancer) has returned after standard treatment. About 28 adults will receive radiation 4 times a week for 1 to 3 weeks. The goal is to find the safest dose that controls the t…

This study uses MRI scans to look at brain tumor biology in 50 adults with glioblastoma that can be surgically removed. The goal is to find imaging markers that can predict which patients will benefit from the drug bevacizumab. Participants will have their tumors analyzed for a p…

This study looks at how much of the drug T-DXd gets into brain tumors in people with HER2-positive brain cancer or glioblastoma. About 30 adults will receive the drug before surgery, and researchers will measure drug levels in the tumor during the operation. The goal is to unders…

This pilot study will use two types of PET scans and a powerful 7Tesla MRI to create detailed metabolic profiles of glioblastoma, both in newly diagnosed and recurrent tumors. Researchers will compare the scan results with lab tests on tumor tissue to better understand how these …

This study tests the drug troriluzole in people with recurrent glioblastoma, a type of brain cancer. Participants take the drug before surgery to see how it affects brain activity and glutamate levels in the tumor. The goal is to learn more about the drug's effects, not to treat …