Sound waves open brain barrier to attack deadly tumors

NCT ID NCT05902169

Recruiting now Disease control Sponsor: CarThera Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated Jun 20, 2026 · Updated 33 times

Summary

This Phase 3 trial tests whether an implanted ultrasound device, SonoCloud-9, can temporarily open the blood-brain barrier to let more carboplatin chemotherapy reach recurrent glioblastoma tumors. About 560 participants will receive either the device plus carboplatin or standard chemotherapy. The main goal is to see if the combination improves overall survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino
ACTIVE_NOT_RECRUITING

Torino, 10126, Italy
CHU de Liège
RECRUITING

Liège, Belgium

Contact
Centre Hospitalier Universitaire Vaudois (CHUV)
ACTIVE_NOT_RECRUITING

Lausanne, 1011, Switzerland
Charité Universitätsmedizin Berlin
ACTIVE_NOT_RECRUITING

Berlin, 10117, Germany
Erasmus Medisch Centrum (Erasmus MC)
ACTIVE_NOT_RECRUITING

Rotterdam, Netherlands
Haaglanden Medisch Centrum
ACTIVE_NOT_RECRUITING

The Hague, 2263, Netherlands
Hospital Clinic de Barcelona
ACTIVE_NOT_RECRUITING

Barcelona, 08036, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Spain

Contact
Hospital Universitario HM Sanchinarro
ACTIVE_NOT_RECRUITING

Madrid, 28050, Spain
Hospital Universitario Virgen del Rocío
ACTIVE_NOT_RECRUITING

Seville, 41013, Spain
Hôpital Foch
ACTIVE_NOT_RECRUITING

Suresnes, 92150, France
Hôpital Neurologique Pierre Wertheimer
RECRUITING

Bron, France

Contact
Hôpital de La Timone
RECRUITING

Marseille, France

Contact
Hôpital de la Pitié-Salpêtrière
RECRUITING

Paris, France

Contact
Indiana University Health
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46202, United States
Inselspital Bern
ACTIVE_NOT_RECRUITING

Bern, 3010, Switzerland
Irccs Istituto Clinico Humanitas
ACTIVE_NOT_RECRUITING

Rozzano, 20089, Italy
Istituto Oncologico Veneto
ACTIVE_NOT_RECRUITING

Padua, Italy
John Hopkins University
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21287, United States
Klinikum Chemnitz gGmbH
ACTIVE_NOT_RECRUITING

Chemnitz, 09113, Germany
Lennox Hill Hospital
ACTIVE_NOT_RECRUITING

New York, New York, 10075, United States
Mayo Clinic Arizona
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 805054, United States
Mayo Clinic Rochester
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic of Jacksonville Florida
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224, United States
Medizinische Universitaet Innsbruck
ACTIVE_NOT_RECRUITING

Innsbruck, 6020, Austria
Miami Cancer Institute
ACTIVE_NOT_RECRUITING

Miami, Florida, 33176, United States
Moffitt Cancer Center
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33612, United States
Neurochirurgie uniklinik Köln
ACTIVE_NOT_RECRUITING

Cologne, Germany
NewYork-Presbyterian / Columbia University Irving Medical Center
ACTIVE_NOT_RECRUITING

New York, New York, 10032, United States
Northwestern University
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Odense University Hospital
ACTIVE_NOT_RECRUITING

Odense, 5000, Denmark
Ospedale Bellaria
ACTIVE_NOT_RECRUITING

Bologna, 40139, Italy
Ospedale Civile di Livorno
ACTIVE_NOT_RECRUITING

Livorno, 57124, Italy
Penn State Health Milton S. Hershey Medical Center
ACTIVE_NOT_RECRUITING

Hershey, Pennsylvania, 17033, United States
Rigshospitalet
ACTIVE_NOT_RECRUITING

Copenhagen, 2100, Denmark
UCHealth
ACTIVE_NOT_RECRUITING

Aurora, Colorado, 80011, United States
Universitair Ziekenhuis Brussel
RECRUITING

Brussels, Belgium

Contact
Universitair Ziekenhuis Leuven
ACTIVE_NOT_RECRUITING

Leuven, Belgium
University of California, San Francisco
ACTIVE_NOT_RECRUITING

San Francisco, California, 94143, United States
University of North Carolina
ACTIVE_NOT_RECRUITING

Chapel Hill, North Carolina, 27516, United States
University of Texas Houston Health Science Center
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
University of Texas Southwestern Medical Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
University of Utah, Hunstman Cancer Institute
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84112, United States
Universitätsklinikum Carl Gustav Carus Dresden
ACTIVE_NOT_RECRUITING

Dresden, 01307, Germany
Universitätsklinikum Essen Klinik für Neurologie
ACTIVE_NOT_RECRUITING

Essen, 45147, Germany
Vall d'Hebron Institute of Oncology (VHIO)
ACTIVE_NOT_RECRUITING

Barcelona, 08035, Spain
Weill Cornell Medicine
ACTIVE_NOT_RECRUITING

New York, New York, 10021, United States
Winship Cancer Institute at Emory University
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30322, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Carboplatin (chemotherapy) delivered with SonoCloud-9 ultrasound device

What this could lead to

If successful, this could offer a more effective treatment option for people with recurrent glioblastoma by getting more chemotherapy into the brain.

What could go wrong

This is a Phase 3 trial, but the approach is novel and may not improve survival. The device requires surgical implantation, which carries risks like infection or bleeding.

Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GBM GLIOBLASTOMA GLIOBLASTOMA RECURRENT GLIOBLASTOMA