Brain tumor DNA test could match kids to smarter treatments
NCT ID NCT05839379
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 46 times
Summary
This study uses genetic testing of brain tumors from children, adolescents, and young adults (ages 1 to 39) with newly diagnosed high-grade glioma, including DIPG. The goal is to identify specific genetic changes in each tumor and then see if patients can join a treatment trial tailored to those changes. Up to 350 participants will have their tumors analyzed, and researchers will also study inherited cancer risks. This is a screening study, not a direct treatment trial.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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C.S. Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Colorado
NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Philadelphia
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dana-Farber Cancer Institute
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke University Health System
RECRUITINGDurham, North Carolina, 27708, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Great Ormond Street Hospital
NOT_YET_RECRUITINGLondon, WC1N 3JH, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hopp Children's Cancer Center at NCT Heidelberg (KiTZ)
NOT_YET_RECRUITINGHeidelberg, Baden-Wurttemberg, 69120, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Montreal Children's Hospital
NOT_YET_RECRUITINGMontreal, Quebec, H4A3J1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Perth Children's Hospital
RECRUITINGPerth, Western Australia, 6000, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Princess Máxima Center
NOT_YET_RECRUITINGUtrecht, 3720, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Queensland Children's Hospital
RECRUITINGSouth Brisbane, Queensland, 4101, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Children's Hospital
RECRUITINGMelbourne, Victoria, 3052, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Starship Children's Hospital
NOT_YET_RECRUITINGAuckland, Grafton, 1023, New Zealand
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sydney Children's Hospital
RECRUITINGRandwick, New South Wales, 2031, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Hospital for Sick Children (SickKids)
NOT_YET_RECRUITINGToronto, Ontario, M5G1X8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could help doctors choose more effective, personalized treatments for young brain tumor patients based on their tumor's genetic makeup.
What could go wrong
This is an early-stage screening study, not a treatment trial. It may not lead to better outcomes for all participants, and some patients may not be eligible for a targeted therapy.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.