WHO GRADE III GLIOMA

This study tests whether adding two different drug combinations after radiation can help children and young adults with high-grade gliomas (including DIPG) live longer. One group receives ribociclib plus everolimus, and another receives ribociclib plus temozolomide, based on the …

This study is for children and young adults with diffuse midline gliomas (DMGs), including DIPG, a rare and aggressive brain tumor. The trial tests whether combining the drug ONC201 with other new agents can help control the disease. About 360 participants will receive different …

This study tests a drug called lorlatinib in children (ages 1-21) with a newly diagnosed, aggressive brain tumor that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given alone or wit…

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This study tests whether a custom video that shows symptoms specific to a patient's brain tumor can lower anxiety during radiation treatment. About 117 patients with newly diagnosed gliomas and their caregivers will take part. The video is made from the patient's own MRI scan and…

This study aims to analyze the genetic makeup of brain tumors in children, teens, and young adults (ages 1 to 39) newly diagnosed with high-grade glioma, including a type called DIPG. By identifying specific genetic changes in each tumor, researchers hope to match patients with m…

This study tests whether advanced MRI scans can better show changes in lower grade brain tumors. About 300 people with these tumors will get special scans to measure how their tumors use energy. The goal is to learn more about tumor behavior and improve how doctors track and trea…