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Ultra-Strong MRI scans could spot ALS earlier

NCT ID NCT07818772

Diagnosis Sponsor: NHS Greater Glasgow and Clyde Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Motor neuron disease (MND), including ALS, is hard to diagnose and often takes years to confirm. This pilot study uses a powerful 7 tesla MRI scanner to look for detailed brain features, called imaging biomarkers, that are specific to MND and its subtypes. Researchers will scan 30 adults with definite or probable MND to see if the technique can reliably show disease-related changes. The early findings are meant to guide larger studies aimed at faster, more specific diagnosis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
7 tesla MRI scanning with a specialist head and neck coil
What this could lead to
If it works, this could give doctors a faster, more specific way to diagnose motor neuron disease and its subtypes, helping patients get into the right trials and treatments sooner.
What could go wrong
This is a small pilot study of 30 people, so it may not find reliable imaging biomarkers or the results may not hold in larger groups. The strong 7T scanner also has more safety restrictions than standard MRI, and some patients may find it uncomfortable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients diagnosed with MND, including subtypes Amyotrophic Lateral Sclerosis (ALS), Primary Lateral Sclerosis (PLS), Progressive Muscular Atrophy (PMA), Progressive Bulbar Palsy (PBP) will be included in the study. Target number of subjects is 30, split into two groups of 15 (scanned on two different coils with different anatomical cover of brainstem and upper cord). These patients will be identified by their clinical Neurology and MND team.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or non-pregnant female patients, ≥18 years of age * Able to give informed consent * Patients diagnosed as definite or probable motor neuron disease (El Escorial Criteria) Exclusion Criteria: * Contraindications to 7T MRI; * active implants, * tattoos in head and neck area * post-surgical brain implants and metal ware * Pregnancy * Unable to comfortably or safely lie flat in an MRI scanner * Respiratory failure * Known major other confounding neurological disease or previous brain surgery * Significant cognitive impairment, including loss of capacity secondary to fronto-temporal dementia * Unable to speak or understand any English (not complying with local 7T MRI safety SOPs) * Unlikely to be able to lie still for the duration of the scan.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis motor neuron disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALS (amyotrophic lateral sclerosis)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ICE Building

    RECRUITING

    Glasgow, G514TF, United Kingdom

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