ALS - AMYOTROPHIC LATERAL SCLEROSIS

This early study tests a device implanted in a blood vessel in the brain that lets people with ALS control computers or devices just by thinking. The goal is to help with daily tasks and improve quality of life. Ten adults with ALS who have weakness in both arms will be enrolled …

This study is testing a new approach for people with motor neuron disease (ALS) that combines a non-invasive brain stimulation technique called rTMS with mixed reality exercise games. The goal is to see if this combination can slow down the disease and improve quality of life. Th…

This study tests whether a probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking probiotics to those on a placebo over 24 weeks. The goal is to see if probiotics can slow dise…

This early-stage study tests a single dose of the gene therapy CTx1000 in 15 people with ALS. The main goal is to see if it is safe and tolerable. Participants must have been diagnosed within the last 2 years and be on stable standard medications.

This program offers the experimental drug SPG302 to adults with ALS who cannot join other clinical trials. The goal is to check if the drug is safe and may help control the disease. Participants must be between 18 and 80 years old, have a confirmed ALS diagnosis, and not be eligi…

This early-stage study tests a new drug called LY4256984 in 32 people with ALS. The drug is given as an injection into the spine to see if it is safe and what side effects may occur. Researchers will also measure how much drug gets into the blood and spinal fluid. The goal is to …

This study tests whether tofersen, a drug already approved for a specific type of ALS, can help people with ALS who do not have the SOD1 gene mutation. About 30 adults will receive the drug via spinal injections over 24 weeks. Researchers will measure nerve damage markers and mon…

This study tests a non-invasive device called MyoRegulator® in 15 people with ALS. The device uses mild electrical stimulation to calm overactive motor neurons, which may help slow muscle decline and improve daily function. The goal is to gather safety and early effectiveness dat…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression and anxiety in adults with COPD, ALS, multiple sclerosis, or atypical Parkinson disease. 108 participants will receive either two moderate-to-high doses or two very low dos…

This study tests a special fabric shoulder brace designed to mimic muscle action. Researchers want to see if it helps people with neuromuscular disorders (like muscular dystrophy or ALS) move their arms and hands better. About 30 participants will be evaluated with and without th…

This study tests a powered neck exoskeleton in 10 people with ALS who have neck weakness. Participants will wear the device and perform tasks like tracking targets and daily activities to see if it improves head movement and is comfortable. The goal is to help patients regain the…

This study tests a tongue exercise program for 20 people with ALS to see if it can help maintain speech and swallowing. Participants will do tongue presses against a device at home five days a week for five weeks, with weekly check-ins from a speech therapist. Researchers will me…

This study is developing a standard test to measure how well assistive technologies and brain-computer interfaces help people with severe motor impairments (like spinal cord injury or ALS) use computers and phones independently. Researchers will have 60 participants perform simul…

This study aims to find new markers in our DNA, proteins, and metabolism that could help diagnose and track brain diseases like Alzheimer's, Parkinson's, and ALS. Researchers will analyze samples from 1,200 people with these conditions using advanced technology. The goal is to be…

This study aims to find biological markers (biomarkers) in body fluids and tissues that can help doctors diagnose ALS and FTD more accurately and earlier. Researchers will analyze samples from 230 people, including those with ALS, FTD, and other conditions, using advanced techniq…

This study uses a new ultra-high-resolution PET scanner to see tiny brain structures in much more detail than before. Researchers will scan 300 healthy volunteers and people with Alzheimer's, Parkinson's, ALS, or psychotic disorders to find early signs of disease. The goal is to …

This study follows nearly 3,000 people, including healthy volunteers and those with memory or movement problems, to track how brain diseases like Alzheimer's and Parkinson's develop over time. Researchers use advanced brain scans and tests to find early signs of disease. The goal…

This study is creating a national registry of 100 people with ALS in Thailand. Researchers will collect information on genetics, symptoms, and how the disease progresses over time. The goal is to better understand ALS in this population and build a foundation for future research.…

This study looks back at the last 10 years to understand how many people in Denmark use a breathing machine at home through a tube in their throat. Researchers will examine which diseases lead to this need and how many patients survive one year after starting. The goal is to gath…