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New hope for rare nasal cancers: targeted pill shows promise in early trial

NCT ID NCT06176989

First seen Nov 01, 2025 · Last updated Jun 15, 2026 · Updated 30 times

Summary

This study tests a daily pill called enasidenib for people with rare cancers of the nasal cavity or skull base that have a specific IDH2 gene mutation. The drug aims to slow or stop tumor growth in cancers that have spread or come back after other treatments. About 40 adults with these advanced cancers will take the drug in 28-day cycles to see if it helps control the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

chondrosarcoma esthesioneuroblastoma Esthesioneuroblastoma, Olfactory sinonasal undifferentiated carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.