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New Huntington's drug trial aims to lower toxic protein levels

NCT ID NCT06585449

First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 28 times

Summary

This early-stage study tests a new drug called ALN-HTT02 in adults with Huntington's disease. The main goal is to check if the drug is safe and how it moves through the body. Researchers will also measure if it lowers the level of the harmful protein that causes the disease. The study involves 66 participants and includes both a placebo group and an open-label phase where everyone gets the drug.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Clinical Trial Site

    RECRUITING

    Edmonton, T6G 2B7, Canada

  • Clinical Trial Site

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    Montreal, H2W 1T8, Canada

  • Clinical Trial Site

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    Ottawa, K1Y4E9, Canada

  • Clinical Trial Site

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    Vancouver, V6T 2B5, Canada

  • Clinical Trial Site

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    Berlin, 10117, Germany

  • Clinical Trial Site

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    Bochum, 44791, Germany

  • Clinical Trial Site

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    Bonn, 53127, Germany

  • Clinical Trial Site

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    Dresden, 01307, Germany

  • Clinical Trial Site

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    Münster, 48149, Germany

  • Clinical Trial Site

    RECRUITING

    Taufkirchen, 84416, Germany

  • Clinical Trial Site

    RECRUITING

    Ulm, 89081, Germany

  • Clinical Trial Site

    RECRUITING

    Birmingham, B15 2TT, United Kingdom

  • Clinical Trial Site

    RECRUITING

    Cambridge, CB2 0PY, United Kingdom

  • Clinical Trial Site

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    Cardiff, CF103AX, United Kingdom

  • Clinical Trial Site

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    Glasgow, G51 4TF, United Kingdom

  • Clinical Trial Site

    RECRUITING

    Greater Manchester, M13 9WL, United Kingdom

  • Clinical Trial Site

    RECRUITING

    London, WC1N 3BG, United Kingdom

  • Clinical Trial Site

    RECRUITING

    Oxford, OX3 9DU, United Kingdom

  • Clinical Trial Site

    RECRUITING

    Plymouth, PL6 8DH, United Kingdom

Conditions

Explore the condition pages connected to this study.