New spinal injection aims to tame Huntington's

NCT ID NCT06585449

Recruiting now Disease control Sponsor: Alnylam Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This early-stage study tests an experimental drug called ALN-HTT02 in 66 adults with Huntington's disease. The drug is given as a single injection into the spine to see if it is safe and how it affects the body. The goal is to reduce levels of the harmful protein that causes the disease, but this is not a cure—it aims to control the disease over time.

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Conditions

The condition(s) this trial relates to.

Huntington disease neurodegenerative disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUNTINGTON'S DISEASE

Contacts and locations

Locations

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Edmonton, T6G 2B7, Canada
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Montreal, H2W 1T8, Canada
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Ottawa, K1Y4E9, Canada
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Vancouver, V6T 2B5, Canada
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Berlin, 10117, Germany
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Bochum, 44791, Germany
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Bonn, 53127, Germany
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Dresden, 01307, Germany
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Münster, 48149, Germany
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Taufkirchen, 84416, Germany
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Ulm, 89081, Germany
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Birmingham, B15 2TT, United Kingdom
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Cambridge, CB2 0PY, United Kingdom
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Cardiff, CF103AX, United Kingdom
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Glasgow, G51 4TF, United Kingdom
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Greater Manchester, M13 9WL, United Kingdom
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London, WC1N 3BG, United Kingdom
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Oxford, OX3 9DU, United Kingdom
Clinical Trial Site
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Plymouth, PL6 8DH, United Kingdom

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